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Transcriptomic reprogramming of genus Paracoccidioides in dimorphism and host niches.
Fungal Genet Biol. 2015 Aug; 81:98-109.FG

Abstract

The thermodimorphic fungi Paracoccidioides brasiliensis and Paracoccidioides lutzii are the etiologic agents of Paracoccidioidomycosis (PCM), the most important endemic systemic mycosis in Latin America. Paracoccidioides grows as saprophytic mycelia that produce infective conidia propagules, which are inhaled into the lungs where the fungus converts to the pathogenic yeast form. From the lungs, Paracoccidioides may disseminate through blood and lymphatics to several other organs and tissues. During the last decade we have witnessed the generation of a large amount of transcriptomic data regarding the events leading to the morphological transition and host niche adaptation. In this review we summarize those findings and discuss the consequence of gene expression plasticity in the persistence and survival of this pathogen. In addition, we discuss the future trends on the host-pathogen studies and how new molecular strategies, such as RNA-seq, dual RNA-seq and Chip-Seq can be powerful tools to improve our understanding on the pathobiology of this systemic mycosis in Latin America.

Authors+Show Affiliations

Lab. de Imunologia Aplicada, CEL/IB, Universidade de Brasília, Brasília-DF, Brazil; Faculdade de Ceilândia, FCE, Universidade de Brasília, Brasília - DF, Brazil.Lab. de Biologia Molecular, CEL/IB, Universidade de Brasília, Brasília-DF, Brazil; Faculdade de Ceilândia, FCE, Universidade de Brasília, Brasília - DF, Brazil.Lab. de Imunologia Aplicada, CEL/IB, Universidade de Brasília, Brasília-DF, Brazil.Lab. de Biologia Molecular, CEL/IB, Universidade de Brasília, Brasília-DF, Brazil.Lab. de Biologia Molecular, CEL/IB, Universidade de Brasília, Brasília-DF, Brazil; Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília - DF, Brazil. Electronic address: msueli@unb.br.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24560614

Citation

Tavares, Aldo Henrique, et al. "Transcriptomic Reprogramming of Genus Paracoccidioides in Dimorphism and Host Niches." Fungal Genetics and Biology : FG & B, vol. 81, 2015, pp. 98-109.
Tavares AH, Fernandes L, Bocca AL, et al. Transcriptomic reprogramming of genus Paracoccidioides in dimorphism and host niches. Fungal Genet Biol. 2015;81:98-109.
Tavares, A. H., Fernandes, L., Bocca, A. L., Silva-Pereira, I., & Felipe, M. S. (2015). Transcriptomic reprogramming of genus Paracoccidioides in dimorphism and host niches. Fungal Genetics and Biology : FG & B, 81, 98-109. https://doi.org/10.1016/j.fgb.2014.01.008
Tavares AH, et al. Transcriptomic Reprogramming of Genus Paracoccidioides in Dimorphism and Host Niches. Fungal Genet Biol. 2015;81:98-109. PubMed PMID: 24560614.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transcriptomic reprogramming of genus Paracoccidioides in dimorphism and host niches. AU - Tavares,Aldo Henrique, AU - Fernandes,Larissa, AU - Bocca,Anamélia Lorenzetti, AU - Silva-Pereira,Ildinete, AU - Felipe,Maria Sueli, Y1 - 2014/02/18/ PY - 2013/09/02/received PY - 2014/01/27/revised PY - 2014/01/31/accepted PY - 2014/2/25/entrez PY - 2014/2/25/pubmed PY - 2016/4/20/medline KW - Dimorphism KW - Host–pathogen interaction KW - Paracoccidioides KW - Transcriptome profiling SP - 98 EP - 109 JF - Fungal genetics and biology : FG & B JO - Fungal Genet Biol VL - 81 N2 - The thermodimorphic fungi Paracoccidioides brasiliensis and Paracoccidioides lutzii are the etiologic agents of Paracoccidioidomycosis (PCM), the most important endemic systemic mycosis in Latin America. Paracoccidioides grows as saprophytic mycelia that produce infective conidia propagules, which are inhaled into the lungs where the fungus converts to the pathogenic yeast form. From the lungs, Paracoccidioides may disseminate through blood and lymphatics to several other organs and tissues. During the last decade we have witnessed the generation of a large amount of transcriptomic data regarding the events leading to the morphological transition and host niche adaptation. In this review we summarize those findings and discuss the consequence of gene expression plasticity in the persistence and survival of this pathogen. In addition, we discuss the future trends on the host-pathogen studies and how new molecular strategies, such as RNA-seq, dual RNA-seq and Chip-Seq can be powerful tools to improve our understanding on the pathobiology of this systemic mycosis in Latin America. SN - 1096-0937 UR - https://www.unboundmedicine.com/medline/citation/24560614/Transcriptomic_reprogramming_of_genus_Paracoccidioides_in_dimorphism_and_host_niches_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1087-1845(14)00017-6 DB - PRIME DP - Unbound Medicine ER -