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1,2,3,4-Tetrahydroisoquinoline produces an antidepressant-like effect in the forced swim test and chronic mild stress model of depression in the rat: Neurochemical correlates.
Eur J Pharmacol. 2014 Apr 15; 729:107-15.EJ

Abstract

1,2,3,4-Tetrahydroisoquinoline (TIQ) is an exo- and endogenous amine naturally present in mammalian brain which displays antidepressant-like effect in various animal models: the forced swim test (FST) and chronic mild stress (CMS) paradigm in rats. To elucidate this action we compared the effects of TIQ with imipramine, a classic antidepressant drug and one of the most clinically effective. Applied behavioral tests showed that TIQ produced an antidepressant-like effect with a potency comparable to that of imipramine. TIQ (25-50mg/kg i.p.), similarly to imipramine (10-30mg/kg i.p.), reduced the immobility time in FST and completely reversed the decrease in sucrose intake caused by CMS in the rat. In addition, in order to avoid the possible psychostimulating effect of TIQ we examined the influence of its administration on locomotor activity in rats. TIQ, like imipramine, produced a reduction in horizontal locomotor activity. This suggested that TIQ did not have psychostimulant properties and that prolonged swimming in the FST was a result of an increased motivation to escape from the stressful situation. The biochemical analyses have shown that TIQ activates monoaminergic systems as a reversible monoamine oxidase (MAO) inhibitor and free radical scavenger. Beyond the activation of noradrenaline and serotonin systems, TIQ also moderately affects the dopamine system. On the basis of the presented behavioral and biochemical studies we suggest that TIQ is a potential new antidepressant which may be effective for the depression therapy in a clinical setting.

Authors+Show Affiliations

Department of Neurochemistry, Institute of Pharmacology, Polish Academy of Sciences, Poland. Electronic address: mozdzen@if-pan.krakow.pl.Department of Pharmacology, Laboratory of Behavioral Pharmacology, Institute of Pharmacology Polish Academy of Sciences, Smętna 12 Street, 31-343 Krakow, Poland.Department of Pharmacology, Laboratory of Behavioral Pharmacology, Institute of Pharmacology Polish Academy of Sciences, Smętna 12 Street, 31-343 Krakow, Poland.Department of Neurochemistry, Institute of Pharmacology, Polish Academy of Sciences, Poland.Department of Neurochemistry, Institute of Pharmacology, Polish Academy of Sciences, Poland.Department of Neurochemistry, Institute of Pharmacology, Polish Academy of Sciences, Poland.Department of Neurochemistry, Institute of Pharmacology, Polish Academy of Sciences, Poland.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24561050

Citation

Możdżeń, Edyta, et al. "1,2,3,4-Tetrahydroisoquinoline Produces an Antidepressant-like Effect in the Forced Swim Test and Chronic Mild Stress Model of Depression in the Rat: Neurochemical Correlates." European Journal of Pharmacology, vol. 729, 2014, pp. 107-15.
Możdżeń E, Papp M, Gruca P, et al. 1,2,3,4-Tetrahydroisoquinoline produces an antidepressant-like effect in the forced swim test and chronic mild stress model of depression in the rat: Neurochemical correlates. Eur J Pharmacol. 2014;729:107-15.
Możdżeń, E., Papp, M., Gruca, P., Wąsik, A., Romańska, I., Michaluk, J., & Antkiewicz-Michaluk, L. (2014). 1,2,3,4-Tetrahydroisoquinoline produces an antidepressant-like effect in the forced swim test and chronic mild stress model of depression in the rat: Neurochemical correlates. European Journal of Pharmacology, 729, 107-15. https://doi.org/10.1016/j.ejphar.2014.01.075
Możdżeń E, et al. 1,2,3,4-Tetrahydroisoquinoline Produces an Antidepressant-like Effect in the Forced Swim Test and Chronic Mild Stress Model of Depression in the Rat: Neurochemical Correlates. Eur J Pharmacol. 2014 Apr 15;729:107-15. PubMed PMID: 24561050.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 1,2,3,4-Tetrahydroisoquinoline produces an antidepressant-like effect in the forced swim test and chronic mild stress model of depression in the rat: Neurochemical correlates. AU - Możdżeń,Edyta, AU - Papp,Mariusz, AU - Gruca,Piotr, AU - Wąsik,Agnieszka, AU - Romańska,Irena, AU - Michaluk,Jerzy, AU - Antkiewicz-Michaluk,Lucyna, Y1 - 2014/02/20/ PY - 2013/07/10/received PY - 2013/12/31/revised PY - 2014/01/28/accepted PY - 2014/2/25/entrez PY - 2014/2/25/pubmed PY - 2014/12/15/medline KW - 1,2,3,4-Tetrahydroisoquinoline KW - Chronic mild stress KW - Forced swimming test KW - Imipramine KW - Metabolism of monoamines KW - Models of depression KW - Rat brain SP - 107 EP - 15 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 729 N2 - 1,2,3,4-Tetrahydroisoquinoline (TIQ) is an exo- and endogenous amine naturally present in mammalian brain which displays antidepressant-like effect in various animal models: the forced swim test (FST) and chronic mild stress (CMS) paradigm in rats. To elucidate this action we compared the effects of TIQ with imipramine, a classic antidepressant drug and one of the most clinically effective. Applied behavioral tests showed that TIQ produced an antidepressant-like effect with a potency comparable to that of imipramine. TIQ (25-50mg/kg i.p.), similarly to imipramine (10-30mg/kg i.p.), reduced the immobility time in FST and completely reversed the decrease in sucrose intake caused by CMS in the rat. In addition, in order to avoid the possible psychostimulating effect of TIQ we examined the influence of its administration on locomotor activity in rats. TIQ, like imipramine, produced a reduction in horizontal locomotor activity. This suggested that TIQ did not have psychostimulant properties and that prolonged swimming in the FST was a result of an increased motivation to escape from the stressful situation. The biochemical analyses have shown that TIQ activates monoaminergic systems as a reversible monoamine oxidase (MAO) inhibitor and free radical scavenger. Beyond the activation of noradrenaline and serotonin systems, TIQ also moderately affects the dopamine system. On the basis of the presented behavioral and biochemical studies we suggest that TIQ is a potential new antidepressant which may be effective for the depression therapy in a clinical setting. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/24561050/1234_Tetrahydroisoquinoline_produces_an_antidepressant_like_effect_in_the_forced_swim_test_and_chronic_mild_stress_model_of_depression_in_the_rat:_Neurochemical_correlates_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(14)00138-1 DB - PRIME DP - Unbound Medicine ER -