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Plasma N-terminal pro B-type natriuretic peptide concentrations in dogs with pulmonic stenosis.
J Vet Med Sci. 2014 Jun; 76(6):827-31.JV

Abstract

The detailed information between plasma N-terminal pro B-type natriuretic peptide (NT-proBNP) concentrations and dogs with pulmonic stenosis (PS) is still unknown. The aim of the present study was to investigate the clinical utility of measuring plasma NT-proBNP concentrations in dogs with PS and to determine whether plasma NT-proBNP concentration could be used to assess disease severity. This retrospective study enrolled 30 client-owned, untreated dogs with PS (asymptomatic [n=23] and symptomatic [n=7]) and 11 healthy laboratory beagles. Results of physical examination, thoracic radiography and echocardiography were recorded. Plasma NT-proBNP concentrations were measured using commercial laboratories. Compared to the healthy control dogs, cardiothoracic ratio was significantly increased in dogs with both asymptomatic and symptomatic PS. Similarly, the ratio of the main pulmonary artery to aorta was significantly decreased in dogs with both asymptomatic and symptomatic PS. The pulmonic pressure gradient in the symptomatic PS dogs was significantly higher than that in the asymptomatic PS dogs. Plasma NT-proBNP concentration was significantly elevated in the symptomatic PS dogs compared to the healthy control dogs and the asymptomatic PS dogs. Furthermore, the Doppler-derived pulmonic pressure gradient was significantly correlated with the plasma NT-proBNP concentration (r=0.78, r(2)=0.61, P<0.0001). Plasma NT-proBNP concentration >764 pmol/l to identify severe PS had a sensitivity of 76.2% and specificity of 81.8%. The plasma NT-proBNP concentration increased by spontaneous PS, i.e. right-sided pressure overload and can be used as an additional method to assess the severity of PS in dogs.

Authors+Show Affiliations

Chimura Veterinary Hospital, 20-13 Minamikarooke, Nakahonmachi, Iwakura, Aichi 482-0042, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24561377

Citation

Kobayashi, Keiya, et al. "Plasma N-terminal Pro B-type Natriuretic Peptide Concentrations in Dogs With Pulmonic Stenosis." The Journal of Veterinary Medical Science, vol. 76, no. 6, 2014, pp. 827-31.
Kobayashi K, Hori Y, Chimura S. Plasma N-terminal pro B-type natriuretic peptide concentrations in dogs with pulmonic stenosis. J Vet Med Sci. 2014;76(6):827-31.
Kobayashi, K., Hori, Y., & Chimura, S. (2014). Plasma N-terminal pro B-type natriuretic peptide concentrations in dogs with pulmonic stenosis. The Journal of Veterinary Medical Science, 76(6), 827-31.
Kobayashi K, Hori Y, Chimura S. Plasma N-terminal Pro B-type Natriuretic Peptide Concentrations in Dogs With Pulmonic Stenosis. J Vet Med Sci. 2014;76(6):827-31. PubMed PMID: 24561377.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma N-terminal pro B-type natriuretic peptide concentrations in dogs with pulmonic stenosis. AU - Kobayashi,Keiya, AU - Hori,Yasutomo, AU - Chimura,Syuuichi, Y1 - 2014/02/24/ PY - 2014/2/25/entrez PY - 2014/2/25/pubmed PY - 2015/3/3/medline SP - 827 EP - 31 JF - The Journal of veterinary medical science JO - J Vet Med Sci VL - 76 IS - 6 N2 - The detailed information between plasma N-terminal pro B-type natriuretic peptide (NT-proBNP) concentrations and dogs with pulmonic stenosis (PS) is still unknown. The aim of the present study was to investigate the clinical utility of measuring plasma NT-proBNP concentrations in dogs with PS and to determine whether plasma NT-proBNP concentration could be used to assess disease severity. This retrospective study enrolled 30 client-owned, untreated dogs with PS (asymptomatic [n=23] and symptomatic [n=7]) and 11 healthy laboratory beagles. Results of physical examination, thoracic radiography and echocardiography were recorded. Plasma NT-proBNP concentrations were measured using commercial laboratories. Compared to the healthy control dogs, cardiothoracic ratio was significantly increased in dogs with both asymptomatic and symptomatic PS. Similarly, the ratio of the main pulmonary artery to aorta was significantly decreased in dogs with both asymptomatic and symptomatic PS. The pulmonic pressure gradient in the symptomatic PS dogs was significantly higher than that in the asymptomatic PS dogs. Plasma NT-proBNP concentration was significantly elevated in the symptomatic PS dogs compared to the healthy control dogs and the asymptomatic PS dogs. Furthermore, the Doppler-derived pulmonic pressure gradient was significantly correlated with the plasma NT-proBNP concentration (r=0.78, r(2)=0.61, P<0.0001). Plasma NT-proBNP concentration >764 pmol/l to identify severe PS had a sensitivity of 76.2% and specificity of 81.8%. The plasma NT-proBNP concentration increased by spontaneous PS, i.e. right-sided pressure overload and can be used as an additional method to assess the severity of PS in dogs. SN - 1347-7439 UR - https://www.unboundmedicine.com/medline/citation/24561377/Plasma_N_terminal_pro_B_type_natriuretic_peptide_concentrations_in_dogs_with_pulmonic_stenosis_ L2 - http://joi.jlc.jst.go.jp/DN/JST.JSTAGE/jvms/13-0554?lang=en&amp;from=PubMed DB - PRIME DP - Unbound Medicine ER -