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Hypolipidemic activity of Phellinus rimosus against triton WR-1339 and high cholesterol diet induced hyperlipidemic rats.
Environ Toxicol Pharmacol. 2014 Mar; 37(2):482-92.ET

Abstract

Patients with the risk for atherosclerotic disease will be targeted to reduce the existing hyperlipidemia. The hypolipidemic activity of Phellinus rimosus was studied using triton WR-1339 and high cholesterol diet (HCD) induced models. The triton induced elevated lipid profile was attenuated by P. rimosus or standard drug atorvastatin. Similarly, administration of P. rimosus along with HCD significantly decline serum triglyceride, total cholesterol, low-density lipoprotein, with elevating the high-density lipoprotein. Thiobarbituric acid reacting substances in heart and liver significantly decreased; where as activity of enzymatic antioxidants and level of reduced glutathione were significantly increased. In both models, P. rimosus extract showed a significant ameliorative effect on the elevated atherogenic index as well as LDL/HDL-C ratio. The hypolipidemic activity of P. rimosus can be ascribed to its inhibitory effect on the liver HMG CoA reductase activity. The results suggest the possible therapeutic potential of this fungus as hypolipidemic agent.

Authors+Show Affiliations

Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur 680555, Kerala, India.Department of Biochemistry, Amala Institute of Medical Sciences, Amala Nagar, Thrissur 680555, Kerala, India.Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur 680555, Kerala, India.Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur 680555, Kerala, India. Electronic address: drkkjanardhanan@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24561532

Citation

Rony, K A., et al. "Hypolipidemic Activity of Phellinus Rimosus Against Triton WR-1339 and High Cholesterol Diet Induced Hyperlipidemic Rats." Environmental Toxicology and Pharmacology, vol. 37, no. 2, 2014, pp. 482-92.
Rony KA, Ajith TA, Nima N, et al. Hypolipidemic activity of Phellinus rimosus against triton WR-1339 and high cholesterol diet induced hyperlipidemic rats. Environ Toxicol Pharmacol. 2014;37(2):482-92.
Rony, K. A., Ajith, T. A., Nima, N., & Janardhanan, K. K. (2014). Hypolipidemic activity of Phellinus rimosus against triton WR-1339 and high cholesterol diet induced hyperlipidemic rats. Environmental Toxicology and Pharmacology, 37(2), 482-92. https://doi.org/10.1016/j.etap.2014.01.004
Rony KA, et al. Hypolipidemic Activity of Phellinus Rimosus Against Triton WR-1339 and High Cholesterol Diet Induced Hyperlipidemic Rats. Environ Toxicol Pharmacol. 2014;37(2):482-92. PubMed PMID: 24561532.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypolipidemic activity of Phellinus rimosus against triton WR-1339 and high cholesterol diet induced hyperlipidemic rats. AU - Rony,K A, AU - Ajith,T A, AU - Nima,N, AU - Janardhanan,K K, Y1 - 2014/01/26/ PY - 2013/10/10/received PY - 2014/01/05/revised PY - 2014/01/13/accepted PY - 2014/2/25/entrez PY - 2014/2/25/pubmed PY - 2014/12/15/medline KW - Antioxidant status KW - Atherogenic index KW - Hypolipidemic effect KW - Lipid profile KW - Phellinus rimosus KW - Triton WR-1339 SP - 482 EP - 92 JF - Environmental toxicology and pharmacology JO - Environ Toxicol Pharmacol VL - 37 IS - 2 N2 - Patients with the risk for atherosclerotic disease will be targeted to reduce the existing hyperlipidemia. The hypolipidemic activity of Phellinus rimosus was studied using triton WR-1339 and high cholesterol diet (HCD) induced models. The triton induced elevated lipid profile was attenuated by P. rimosus or standard drug atorvastatin. Similarly, administration of P. rimosus along with HCD significantly decline serum triglyceride, total cholesterol, low-density lipoprotein, with elevating the high-density lipoprotein. Thiobarbituric acid reacting substances in heart and liver significantly decreased; where as activity of enzymatic antioxidants and level of reduced glutathione were significantly increased. In both models, P. rimosus extract showed a significant ameliorative effect on the elevated atherogenic index as well as LDL/HDL-C ratio. The hypolipidemic activity of P. rimosus can be ascribed to its inhibitory effect on the liver HMG CoA reductase activity. The results suggest the possible therapeutic potential of this fungus as hypolipidemic agent. SN - 1872-7077 UR - https://www.unboundmedicine.com/medline/citation/24561532/Hypolipidemic_activity_of_Phellinus_rimosus_against_triton_WR_1339_and_high_cholesterol_diet_induced_hyperlipidemic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1382-6689(14)00005-2 DB - PRIME DP - Unbound Medicine ER -