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The roles of a novel anti-inflammatory factor, milk fat globule-epidermal growth factor 8, in patients with coronary atherosclerotic heart disease.
Atherosclerosis. 2014 Apr; 233(2):661-665.A

Abstract

OBJECTIVE

Inflammation is now considered a main pathogenic factor in coronary atherosclerotic heart disease (CHD), and it has a positive correlation with plaque vulnerability. A novel anti-inflammatory factor, milk fat globule-epidermal growth factor 8 (MFG-E8), has been reported as having prominent anti-inflammatory effects in sepsis. However, few studies have reported on the association between MFG-E8 and CHD. In the present study, we aimed to investigate the serum MFG-E8 concentrations in patients with different stages of CHD or without CHD. Then, we studied the associations among MFG-E8, Gensini score, and high-sensitivity C-reactive protein (hs-CRP) in Chinese patients with CHD to illustrate the role of MFG-E8 in CHD.

METHODS

A total of 176 controls and 295 patients with CHD were selected for this study. To evaluate CHD severity, we calculated the Gensini score for all of the subjects. Serum levels of MFG-E8 were determined by an enzyme-linked immunosorbent assay (ELISA) kit; serum total cholesterol (TC), high density lipoprotein-cholesterol (HDL-c), low density lipoprotein-cholesterol (LDL-c), triglyceride (TG), and hs-CRP were detected by an automatic biochemistry analyzer; and fibrinogen (FIB) was analyzed with an automatic coagulation analyzer.

RESULTS

Compared with the controls, the CHD group had a lower level of MFG-E8 (673.20±112.34 ng/mL vs. 134.89±4.74 ng/mL, p<0.001). The level of serum MFG-E8 in the acute myocardial infarction group (118.07±10.10 ng/mL) was significantly less than that in the stable angina group (p=0.025). Further analysis showed that MFG-E8 had a negative association with the Gensini score and the hs-CRP level (r=-0.590, p<0.001; r=-0.105, p=0.022, respectively). In addition, multiple regression analysis of the association between MFG-E8 and the main cardiovascular risk factors in our cases showed that MFG-E8 had a negative association with hs-CRP and a positive association with LDL-c (all p<0.05).

CONCLUSION

The serum level of MFG-E8 was negatively associated with the severity of coronary artery stenosis and the risk of clinical events. Thus, MFG-E8 has the potential to be a marker of vascular complications.

Authors+Show Affiliations

Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China. Electronic address: diane919@qq.com.Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China. Electronic address: yanlitf1120@163.com.Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China. Electronic address: lvyongnan@hotmail.com.Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China; Department of Clinical Laboratory, Affiliated Hospital of You Jiang Medical University for Nationalities, Baise, Guangxi, China. Electronic address: chuandongwei@163.com.Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China. Electronic address: shenzheng2008@163.com.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24561551

Citation

Dai, Wen, et al. "The Roles of a Novel Anti-inflammatory Factor, Milk Fat Globule-epidermal Growth Factor 8, in Patients With Coronary Atherosclerotic Heart Disease." Atherosclerosis, vol. 233, no. 2, 2014, pp. 661-665.
Dai W, Li Y, Lv YN, et al. The roles of a novel anti-inflammatory factor, milk fat globule-epidermal growth factor 8, in patients with coronary atherosclerotic heart disease. Atherosclerosis. 2014;233(2):661-665.
Dai, W., Li, Y., Lv, Y. N., Wei, C. D., & Zheng, H. Y. (2014). The roles of a novel anti-inflammatory factor, milk fat globule-epidermal growth factor 8, in patients with coronary atherosclerotic heart disease. Atherosclerosis, 233(2), 661-665. https://doi.org/10.1016/j.atherosclerosis.2014.01.013
Dai W, et al. The Roles of a Novel Anti-inflammatory Factor, Milk Fat Globule-epidermal Growth Factor 8, in Patients With Coronary Atherosclerotic Heart Disease. Atherosclerosis. 2014;233(2):661-665. PubMed PMID: 24561551.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The roles of a novel anti-inflammatory factor, milk fat globule-epidermal growth factor 8, in patients with coronary atherosclerotic heart disease. AU - Dai,Wen, AU - Li,Yan, AU - Lv,Yong-Nan, AU - Wei,Chuan-Dong, AU - Zheng,Hong-Yun, Y1 - 2014/01/22/ PY - 2013/06/16/received PY - 2013/12/31/revised PY - 2014/01/06/accepted PY - 2014/2/25/entrez PY - 2014/2/25/pubmed PY - 2014/12/17/medline KW - Coronary atherosclerotic heart disease KW - Inflammation KW - MFG-E8 SP - 661 EP - 665 JF - Atherosclerosis JO - Atherosclerosis VL - 233 IS - 2 N2 - OBJECTIVE: Inflammation is now considered a main pathogenic factor in coronary atherosclerotic heart disease (CHD), and it has a positive correlation with plaque vulnerability. A novel anti-inflammatory factor, milk fat globule-epidermal growth factor 8 (MFG-E8), has been reported as having prominent anti-inflammatory effects in sepsis. However, few studies have reported on the association between MFG-E8 and CHD. In the present study, we aimed to investigate the serum MFG-E8 concentrations in patients with different stages of CHD or without CHD. Then, we studied the associations among MFG-E8, Gensini score, and high-sensitivity C-reactive protein (hs-CRP) in Chinese patients with CHD to illustrate the role of MFG-E8 in CHD. METHODS: A total of 176 controls and 295 patients with CHD were selected for this study. To evaluate CHD severity, we calculated the Gensini score for all of the subjects. Serum levels of MFG-E8 were determined by an enzyme-linked immunosorbent assay (ELISA) kit; serum total cholesterol (TC), high density lipoprotein-cholesterol (HDL-c), low density lipoprotein-cholesterol (LDL-c), triglyceride (TG), and hs-CRP were detected by an automatic biochemistry analyzer; and fibrinogen (FIB) was analyzed with an automatic coagulation analyzer. RESULTS: Compared with the controls, the CHD group had a lower level of MFG-E8 (673.20±112.34 ng/mL vs. 134.89±4.74 ng/mL, p<0.001). The level of serum MFG-E8 in the acute myocardial infarction group (118.07±10.10 ng/mL) was significantly less than that in the stable angina group (p=0.025). Further analysis showed that MFG-E8 had a negative association with the Gensini score and the hs-CRP level (r=-0.590, p<0.001; r=-0.105, p=0.022, respectively). In addition, multiple regression analysis of the association between MFG-E8 and the main cardiovascular risk factors in our cases showed that MFG-E8 had a negative association with hs-CRP and a positive association with LDL-c (all p<0.05). CONCLUSION: The serum level of MFG-E8 was negatively associated with the severity of coronary artery stenosis and the risk of clinical events. Thus, MFG-E8 has the potential to be a marker of vascular complications. SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/24561551/The_roles_of_a_novel_anti_inflammatory_factor_milk_fat_globule_epidermal_growth_factor_8_in_patients_with_coronary_atherosclerotic_heart_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(14)00037-9 DB - PRIME DP - Unbound Medicine ER -