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Sesquiterpene lactones from Mikania micrantha and Mikania cordifolia and their cytotoxic and anti-inflammatory evaluation.
Fitoterapia. 2014 Apr; 94:155-63.F

Abstract

The guaianolide 8-epi-mikanokryptin (1) and the melampolide 11Hβ-11,13-dihydromicrantholide (2) along with known sesquiterpene lactones (3-13) and other constituents were isolated from the aerial parts of different populations of Mikania micrantha and Mikania cordifolia collected in several states of Mexico. The relative and absolute configurations of 1 were determined by X-ray diffraction and CD analysis, respectively. Considering the (1)H and (13)C NMR chemical shift similarities and the H-H coupling constant values, a [(1)D(14), (15)D5] conformation was established for micrantholides (2, 8-13). We tested nearly all the sesquiterpene lactones for antiproliferative activity in human cancer cell lines, and they exhibited moderate activity. Additionally, in a mouse ear model of edema induced by TPA, the anti-inflammatory activities were marginal.

Authors+Show Affiliations

Programa de Química, Facultad de Ciencias Básicas, Universidad del Quindío, Carrera 15, Calle 12 Norte, Armenia, Quindío, Colombia; Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, México, D.F., Mexico.Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, México, D.F., Mexico.Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, México, D.F., Mexico.Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, México, D.F., Mexico.Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, México, D.F., Mexico.Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, México, D.F., Mexico.Centro de Investigaciones en Ecosistemas, Universidad Nacional Autónoma de México, Antigua carretera a Pátzcuaro No. 8701, Col. Ex-Hacienda de San José de la Huerta, 58190 Morelia, Michoacán, Mexico.Centro de Investigaciones en Ecosistemas, Universidad Nacional Autónoma de México, Antigua carretera a Pátzcuaro No. 8701, Col. Ex-Hacienda de San José de la Huerta, 58190 Morelia, Michoacán, Mexico.Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, México, D.F., Mexico. Electronic address: delgado@unam.mx.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24565963

Citation

Ríos, Eunice V., et al. "Sesquiterpene Lactones From Mikania Micrantha and Mikania Cordifolia and Their Cytotoxic and Anti-inflammatory Evaluation." Fitoterapia, vol. 94, 2014, pp. 155-63.
Ríos EV, León A, Chávez MI, et al. Sesquiterpene lactones from Mikania micrantha and Mikania cordifolia and their cytotoxic and anti-inflammatory evaluation. Fitoterapia. 2014;94:155-63.
Ríos, E. V., León, A., Chávez, M. I., Torres, Y., Ramírez-Apan, M. T., Toscano, R. A., Bravo-Monzón, Á. E., Espinosa-García, F. J., & Delgado, G. (2014). Sesquiterpene lactones from Mikania micrantha and Mikania cordifolia and their cytotoxic and anti-inflammatory evaluation. Fitoterapia, 94, 155-63. https://doi.org/10.1016/j.fitote.2014.02.006
Ríos EV, et al. Sesquiterpene Lactones From Mikania Micrantha and Mikania Cordifolia and Their Cytotoxic and Anti-inflammatory Evaluation. Fitoterapia. 2014;94:155-63. PubMed PMID: 24565963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sesquiterpene lactones from Mikania micrantha and Mikania cordifolia and their cytotoxic and anti-inflammatory evaluation. AU - Ríos,Eunice V, AU - León,Alejandra, AU - Chávez,María Isabel, AU - Torres,Yuridia, AU - Ramírez-Apan,María Teresa, AU - Toscano,Rubén A, AU - Bravo-Monzón,Ángel E, AU - Espinosa-García,Francisco J, AU - Delgado,Guillermo, Y1 - 2014/02/22/ PY - 2013/11/15/received PY - 2014/02/11/revised PY - 2014/02/14/accepted PY - 2014/2/26/entrez PY - 2014/2/26/pubmed PY - 2015/1/13/medline KW - Anti-inflammatory activity KW - Cytotoxic activity KW - Mikania cordifolia KW - Mikania micrantha KW - Sesquiterpene lactones SP - 155 EP - 63 JF - Fitoterapia JO - Fitoterapia VL - 94 N2 - The guaianolide 8-epi-mikanokryptin (1) and the melampolide 11Hβ-11,13-dihydromicrantholide (2) along with known sesquiterpene lactones (3-13) and other constituents were isolated from the aerial parts of different populations of Mikania micrantha and Mikania cordifolia collected in several states of Mexico. The relative and absolute configurations of 1 were determined by X-ray diffraction and CD analysis, respectively. Considering the (1)H and (13)C NMR chemical shift similarities and the H-H coupling constant values, a [(1)D(14), (15)D5] conformation was established for micrantholides (2, 8-13). We tested nearly all the sesquiterpene lactones for antiproliferative activity in human cancer cell lines, and they exhibited moderate activity. Additionally, in a mouse ear model of edema induced by TPA, the anti-inflammatory activities were marginal. SN - 1873-6971 UR - https://www.unboundmedicine.com/medline/citation/24565963/Sesquiterpene_lactones_from_Mikania_micrantha_and_Mikania_cordifolia_and_their_cytotoxic_and_anti_inflammatory_evaluation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0367-326X(14)00049-5 DB - PRIME DP - Unbound Medicine ER -