Tags

Type your tag names separated by a space and hit enter

Obesity prevalence in relation to gut microbial environments capable of producing equol or O-desmethylangolensin from the isoflavone daidzein.
Eur J Clin Nutr. 2014 Apr; 68(4):526-30.EJ

Abstract

BACKGROUND/OBJECTIVES

Studies have observed associations between the gut microbiome and obesity. O-desmethylangolensin (ODMA) and equol are gut bacterial metabolites of daidzein, a compound found in high amounts in soy foods. Approximately 80-95% and 25-60% of individuals harbor gut microbial communities capable of producing ODMA or equol, respectively. Given that other phenotypes of gut bacterial metabolism of dietary compounds have been associated with obesity, we hypothesized that daidzein-metabolizing phenotypes would be associated with obesity. The objective of this study was to compare the prevalence of ODMA-producer and equol-producer phenotypes in obese, overweight and normal-weight individuals.

SUBJECTS/METHODS

Adults aged 18-95 years (n=297) provided a first-void urine sample after a 3-day soy challenge, and urinary ODMA and equol concentrations were used to classify individuals as producers or non-producers. Body mass index was calculated from self-reported weight and height.

RESULTS

There were 60 ODMA non-producers and 173 equol non-producers. Obese individuals were 2.8 times more likely to be ODMA non-producers (odds ratio (OR)=2.8, 95% confidence interval (CI): 1.2, 6.2) compared with normal-weight individuals, when adjusted for age, race (white vs non-white), and gender and menopausal status (male, premenopausal female and postmenopausal female). Obesity was not associated with equol-producer phenotype (OR=1.1, 95% CI: 0.5, 2.2). Stronger associations with obesity were observed in the ODMA non-producers who were also equol producers than in the equol non-producers.

CONCLUSIONS

Results from this analysis suggest that the ODMA-producer phenotype, but not equol-producer phenotype, is associated with obesity in adults. These results support further work to replicate these findings and evaluate the mechanisms of the observed associations.

Authors+Show Affiliations

Department of Global and Community Health, George Mason University, Fairfax, VA, USA.Bristol Dental School, University of Bristol, Bristol, UK.Department of Chemistry, University of Helsinki, Helsinki, Finland.Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24569543

Citation

Frankenfeld, C L., et al. "Obesity Prevalence in Relation to Gut Microbial Environments Capable of Producing Equol or O-desmethylangolensin From the Isoflavone Daidzein." European Journal of Clinical Nutrition, vol. 68, no. 4, 2014, pp. 526-30.
Frankenfeld CL, Atkinson C, Wähälä K, et al. Obesity prevalence in relation to gut microbial environments capable of producing equol or O-desmethylangolensin from the isoflavone daidzein. Eur J Clin Nutr. 2014;68(4):526-30.
Frankenfeld, C. L., Atkinson, C., Wähälä, K., & Lampe, J. W. (2014). Obesity prevalence in relation to gut microbial environments capable of producing equol or O-desmethylangolensin from the isoflavone daidzein. European Journal of Clinical Nutrition, 68(4), 526-30. https://doi.org/10.1038/ejcn.2014.23
Frankenfeld CL, et al. Obesity Prevalence in Relation to Gut Microbial Environments Capable of Producing Equol or O-desmethylangolensin From the Isoflavone Daidzein. Eur J Clin Nutr. 2014;68(4):526-30. PubMed PMID: 24569543.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Obesity prevalence in relation to gut microbial environments capable of producing equol or O-desmethylangolensin from the isoflavone daidzein. AU - Frankenfeld,C L, AU - Atkinson,C, AU - Wähälä,K, AU - Lampe,J W, Y1 - 2014/02/26/ PY - 2013/10/06/received PY - 2014/01/14/revised PY - 2014/01/21/accepted PY - 2014/2/27/entrez PY - 2014/2/27/pubmed PY - 2014/12/15/medline SP - 526 EP - 30 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 68 IS - 4 N2 - BACKGROUND/OBJECTIVES: Studies have observed associations between the gut microbiome and obesity. O-desmethylangolensin (ODMA) and equol are gut bacterial metabolites of daidzein, a compound found in high amounts in soy foods. Approximately 80-95% and 25-60% of individuals harbor gut microbial communities capable of producing ODMA or equol, respectively. Given that other phenotypes of gut bacterial metabolism of dietary compounds have been associated with obesity, we hypothesized that daidzein-metabolizing phenotypes would be associated with obesity. The objective of this study was to compare the prevalence of ODMA-producer and equol-producer phenotypes in obese, overweight and normal-weight individuals. SUBJECTS/METHODS: Adults aged 18-95 years (n=297) provided a first-void urine sample after a 3-day soy challenge, and urinary ODMA and equol concentrations were used to classify individuals as producers or non-producers. Body mass index was calculated from self-reported weight and height. RESULTS: There were 60 ODMA non-producers and 173 equol non-producers. Obese individuals were 2.8 times more likely to be ODMA non-producers (odds ratio (OR)=2.8, 95% confidence interval (CI): 1.2, 6.2) compared with normal-weight individuals, when adjusted for age, race (white vs non-white), and gender and menopausal status (male, premenopausal female and postmenopausal female). Obesity was not associated with equol-producer phenotype (OR=1.1, 95% CI: 0.5, 2.2). Stronger associations with obesity were observed in the ODMA non-producers who were also equol producers than in the equol non-producers. CONCLUSIONS: Results from this analysis suggest that the ODMA-producer phenotype, but not equol-producer phenotype, is associated with obesity in adults. These results support further work to replicate these findings and evaluate the mechanisms of the observed associations. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/24569543/Obesity_prevalence_in_relation_to_gut_microbial_environments_capable_of_producing_equol_or_O_desmethylangolensin_from_the_isoflavone_daidzein_ L2 - https://doi.org/10.1038/ejcn.2014.23 DB - PRIME DP - Unbound Medicine ER -