Citation
Rix, Thomas A., et al. "A U-shaped Association Between Consumption of Marine N-3 Fatty Acids and Development of Atrial Fibrillation/atrial Flutter-a Danish Cohort Study." Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups On Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology, vol. 16, no. 11, 2014, pp. 1554-61.
Rix TA, Joensen AM, Riahi S, et al. A U-shaped association between consumption of marine n-3 fatty acids and development of atrial fibrillation/atrial flutter-a Danish cohort study. Europace. 2014;16(11):1554-61.
Rix, T. A., Joensen, A. M., Riahi, S., Lundbye-Christensen, S., Tjønneland, A., Schmidt, E. B., & Overvad, K. (2014). A U-shaped association between consumption of marine n-3 fatty acids and development of atrial fibrillation/atrial flutter-a Danish cohort study. Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups On Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology, 16(11), 1554-61. https://doi.org/10.1093/europace/euu019
Rix TA, et al. A U-shaped Association Between Consumption of Marine N-3 Fatty Acids and Development of Atrial Fibrillation/atrial Flutter-a Danish Cohort Study. Europace. 2014;16(11):1554-61. PubMed PMID: 24574493.
TY - JOUR
T1 - A U-shaped association between consumption of marine n-3 fatty acids and development of atrial fibrillation/atrial flutter-a Danish cohort study.
AU - Rix,Thomas A,
AU - Joensen,Albert M,
AU - Riahi,Sam,
AU - Lundbye-Christensen,Søren,
AU - Tjønneland,Anne,
AU - Schmidt,Erik B,
AU - Overvad,Kim,
Y1 - 2014/02/26/
PY - 2014/2/28/entrez
PY - 2014/2/28/pubmed
PY - 2015/6/30/medline
KW - Atrial fibrillation
KW - Diet
KW - Fish
KW - n-3 Polyunsaturated fatty acids
SP - 1554
EP - 61
JF - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
JO - Europace
VL - 16
IS - 11
N2 - AIMS: Previous studies have suggested a lower risk of atrial fibrillation (AF) with higher intakes of fish and marine n-3 polyunsaturated fatty acids (PUFAs), but the results have been inconsistent. The aim was to investigate the association between consumption of marine n-3 PUFA and development of AF. METHODS AND RESULTS: A total of 57 053 Danish participants 50-64 years of age were enrolled in the Diet, Cancer, and Health Cohort Study between 1993 and 1997. Dietary intake of fish and marine n-3 PUFA was assessed by a semi-quantitative food frequency questionnaire. In total, 3345 incident cases of AF occurred over 13.6 years. Multivariate Cox regression analyses (3284 cases and 55 246 participants) using cubic splines showed a U-shaped association between consumption of marine n-3 PUFA and risk of incident AF, with the lowest risk of AF at a moderate intake of 0.63 g/day. For quintiles of marine n-3 PUFA intake, a 13% statistically significant lower risk of AF was seen in the middle vs. lowest quintile: Q1 reference, Q2 HR 0.92 (95% CI 0.82-1.03), Q3 HR 0.87 (95% CI 0.78-0.98), Q4 HR 0.96 (95% CI 0.86-1.08), and Q5 HR 1.05 (95% CI 0.93-1.18). Intake of total fish, fatty fish, and the individual n-3 PUFA eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid also showed U-shaped associations with incident AF. CONCLUSION: We found a U-shaped association between consumption of marine n-3 PUFA and risk of incident AF, with the lowest risk close to the median intake of total marine n-3 PUFA (0.63 g/day).
SN - 1532-2092
UR - https://www.unboundmedicine.com/medline/citation/24574493/A_U_shaped_association_between_consumption_of_marine_n_3_fatty_acids_and_development_of_atrial_fibrillation/atrial_flutter_a_Danish_cohort_study_
L2 - https://academic.oup.com/europace/article-lookup/doi/10.1093/europace/euu019
DB - PRIME
DP - Unbound Medicine
ER -