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Impairment of ghrelin synthesis in Helicobacter pylori-colonized stomach: new clues for the pathogenesis of H. pylori-related gastric inflammation.
World J Gastroenterol. 2014 Jan 21; 20(3):639-46.WJ

Abstract

Ghrelin, the ligand of growth hormone secretagogue receptor 1a, takes part in several functions of the digestive system, including regulation of appetite, energy homeostasis, gastric acid secretion and motility. Ghrelin has also immunoregulatory properties and is supposed to inhibit some inflammatory pathways that can mediate gastric damage. Interestingly, ghrelin synthesis is reduced in the gastric mucosa of patients with Helicobacter pylori (H. pylori) infection, a worldwide condition inducing a T helper (Th)1/Th17 cell response-driven gastritis, which may evolve towards gastric atrophy and cancer. In this article, we review the available data on the expression of ghrelin in H. pylori infection and discuss how the defective ghrelin synthesis may contribute to sustain the ongoing inflammatory response in this disease.

Authors+Show Affiliations

Omero Alessandro Paoluzi, Giovanna Del Vecchio Blanco, Roberta Caruso, Ivan Monteleone, Giovanni Monteleone, Francesco Pallone, Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.Omero Alessandro Paoluzi, Giovanna Del Vecchio Blanco, Roberta Caruso, Ivan Monteleone, Giovanni Monteleone, Francesco Pallone, Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.Omero Alessandro Paoluzi, Giovanna Del Vecchio Blanco, Roberta Caruso, Ivan Monteleone, Giovanni Monteleone, Francesco Pallone, Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.Omero Alessandro Paoluzi, Giovanna Del Vecchio Blanco, Roberta Caruso, Ivan Monteleone, Giovanni Monteleone, Francesco Pallone, Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.Omero Alessandro Paoluzi, Giovanna Del Vecchio Blanco, Roberta Caruso, Ivan Monteleone, Giovanni Monteleone, Francesco Pallone, Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.Omero Alessandro Paoluzi, Giovanna Del Vecchio Blanco, Roberta Caruso, Ivan Monteleone, Giovanni Monteleone, Francesco Pallone, Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24574737

Citation

Paoluzi, Omero Alessandro, et al. "Impairment of Ghrelin Synthesis in Helicobacter Pylori-colonized Stomach: New Clues for the Pathogenesis of H. Pylori-related Gastric Inflammation." World Journal of Gastroenterology, vol. 20, no. 3, 2014, pp. 639-46.
Paoluzi OA, Blanco del VG, Caruso R, et al. Impairment of ghrelin synthesis in Helicobacter pylori-colonized stomach: new clues for the pathogenesis of H. pylori-related gastric inflammation. World J Gastroenterol. 2014;20(3):639-46.
Paoluzi, O. A., Blanco, d. e. l. . V. G., Caruso, R., Monteleone, I., Monteleone, G., & Pallone, F. (2014). Impairment of ghrelin synthesis in Helicobacter pylori-colonized stomach: new clues for the pathogenesis of H. pylori-related gastric inflammation. World Journal of Gastroenterology, 20(3), 639-46. https://doi.org/10.3748/wjg.v20.i3.639
Paoluzi OA, et al. Impairment of Ghrelin Synthesis in Helicobacter Pylori-colonized Stomach: New Clues for the Pathogenesis of H. Pylori-related Gastric Inflammation. World J Gastroenterol. 2014 Jan 21;20(3):639-46. PubMed PMID: 24574737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impairment of ghrelin synthesis in Helicobacter pylori-colonized stomach: new clues for the pathogenesis of H. pylori-related gastric inflammation. AU - Paoluzi,Omero Alessandro, AU - Blanco,Del Vecchio Giovanna, AU - Caruso,Roberta, AU - Monteleone,Ivan, AU - Monteleone,Giovanni, AU - Pallone,Francesco, PY - 2013/10/04/received PY - 2013/11/14/revised PY - 2013/12/05/accepted PY - 2014/2/28/entrez PY - 2014/2/28/pubmed PY - 2014/11/18/medline KW - Gastritis KW - Ghrelin KW - Helicobacter pylori KW - T helper 1 cells SP - 639 EP - 46 JF - World journal of gastroenterology JO - World J Gastroenterol VL - 20 IS - 3 N2 - Ghrelin, the ligand of growth hormone secretagogue receptor 1a, takes part in several functions of the digestive system, including regulation of appetite, energy homeostasis, gastric acid secretion and motility. Ghrelin has also immunoregulatory properties and is supposed to inhibit some inflammatory pathways that can mediate gastric damage. Interestingly, ghrelin synthesis is reduced in the gastric mucosa of patients with Helicobacter pylori (H. pylori) infection, a worldwide condition inducing a T helper (Th)1/Th17 cell response-driven gastritis, which may evolve towards gastric atrophy and cancer. In this article, we review the available data on the expression of ghrelin in H. pylori infection and discuss how the defective ghrelin synthesis may contribute to sustain the ongoing inflammatory response in this disease. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/24574737/Impairment_of_ghrelin_synthesis_in_Helicobacter_pylori_colonized_stomach:_new_clues_for_the_pathogenesis_of_H__pylori_related_gastric_inflammation_ L2 - https://www.wjgnet.com/1007-9327/full/v20/i3/639.htm DB - PRIME DP - Unbound Medicine ER -