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Role of the gut microbiota in inflammatory bowel disease pathogenesis: what have we learnt in the past 10 years?
World J Gastroenterol 2014; 20(5):1192-210WJ

Abstract

Our understanding of the microbial involvement in inflammatory bowel disease (IBD) pathogenesis has increased exponentially over the past decade. The development of newer molecular tools for the global assessment of the gut microbiome and the identification of nucleotide-binding oligomerization domain-containing protein 2 in 2001 and other susceptibility genes for Crohn's disease in particular has led to better understanding of the aetiopathogenesis of IBD. The microbial studies have elaborated the normal composition of the gut microbiome and its perturbations in the setting of IBD. This altered microbiome or "dysbiosis" is a key player in the protracted course of inflammation in IBD. Numerous genome-wide association studies have identified further genes involved in gastrointestinal innate immunity (including polymorphisms in genes involved in autophagy: ATG16L1 and IGRM), which have helped elucidate the relationship of the local innate immunity with the adjacent luminal bacteria. These developments have also spurred the search for specific pathogens which may have a role in the metamorphosis of the gut microbiome from a symbiotic entity to a putative pathogenic one. Here we review advances in our understanding of microbial involvement in IBD pathogenesis over the past 10 years and offer insight into how this will shape our therapeutic management of the disease in the coming years.

Authors+Show Affiliations

Georgina L Hold, Megan Smith, Charlie Grange, Euan Robert Watt, Emad M El-Omar, Indrani Mukhopadhya, Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen AB252ZD, United Kingdom.Georgina L Hold, Megan Smith, Charlie Grange, Euan Robert Watt, Emad M El-Omar, Indrani Mukhopadhya, Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen AB252ZD, United Kingdom.Georgina L Hold, Megan Smith, Charlie Grange, Euan Robert Watt, Emad M El-Omar, Indrani Mukhopadhya, Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen AB252ZD, United Kingdom.Georgina L Hold, Megan Smith, Charlie Grange, Euan Robert Watt, Emad M El-Omar, Indrani Mukhopadhya, Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen AB252ZD, United Kingdom.Georgina L Hold, Megan Smith, Charlie Grange, Euan Robert Watt, Emad M El-Omar, Indrani Mukhopadhya, Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen AB252ZD, United Kingdom.Georgina L Hold, Megan Smith, Charlie Grange, Euan Robert Watt, Emad M El-Omar, Indrani Mukhopadhya, Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen AB252ZD, United Kingdom.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24574795

Citation

Hold, Georgina L., et al. "Role of the Gut Microbiota in Inflammatory Bowel Disease Pathogenesis: what Have We Learnt in the Past 10 Years?" World Journal of Gastroenterology, vol. 20, no. 5, 2014, pp. 1192-210.
Hold GL, Smith M, Grange C, et al. Role of the gut microbiota in inflammatory bowel disease pathogenesis: what have we learnt in the past 10 years? World J Gastroenterol. 2014;20(5):1192-210.
Hold, G. L., Smith, M., Grange, C., Watt, E. R., El-Omar, E. M., & Mukhopadhya, I. (2014). Role of the gut microbiota in inflammatory bowel disease pathogenesis: what have we learnt in the past 10 years? World Journal of Gastroenterology, 20(5), pp. 1192-210. doi:10.3748/wjg.v20.i5.1192.
Hold GL, et al. Role of the Gut Microbiota in Inflammatory Bowel Disease Pathogenesis: what Have We Learnt in the Past 10 Years. World J Gastroenterol. 2014 Feb 7;20(5):1192-210. PubMed PMID: 24574795.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of the gut microbiota in inflammatory bowel disease pathogenesis: what have we learnt in the past 10 years? AU - Hold,Georgina L, AU - Smith,Megan, AU - Grange,Charlie, AU - Watt,Euan Robert, AU - El-Omar,Emad M, AU - Mukhopadhya,Indrani, PY - 2013/09/28/received PY - 2013/11/19/revised PY - 2014/01/06/accepted PY - 2014/2/28/entrez PY - 2014/2/28/pubmed PY - 2014/11/18/medline KW - Crohn’s disease KW - Faecal transplant KW - Gut microbiota KW - Inflammatory bowel disease KW - Innate immune response KW - Prebiotics KW - Probiotics KW - Ulcerative colitis SP - 1192 EP - 210 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 20 IS - 5 N2 - Our understanding of the microbial involvement in inflammatory bowel disease (IBD) pathogenesis has increased exponentially over the past decade. The development of newer molecular tools for the global assessment of the gut microbiome and the identification of nucleotide-binding oligomerization domain-containing protein 2 in 2001 and other susceptibility genes for Crohn's disease in particular has led to better understanding of the aetiopathogenesis of IBD. The microbial studies have elaborated the normal composition of the gut microbiome and its perturbations in the setting of IBD. This altered microbiome or "dysbiosis" is a key player in the protracted course of inflammation in IBD. Numerous genome-wide association studies have identified further genes involved in gastrointestinal innate immunity (including polymorphisms in genes involved in autophagy: ATG16L1 and IGRM), which have helped elucidate the relationship of the local innate immunity with the adjacent luminal bacteria. These developments have also spurred the search for specific pathogens which may have a role in the metamorphosis of the gut microbiome from a symbiotic entity to a putative pathogenic one. Here we review advances in our understanding of microbial involvement in IBD pathogenesis over the past 10 years and offer insight into how this will shape our therapeutic management of the disease in the coming years. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/24574795/Role_of_the_gut_microbiota_in_inflammatory_bowel_disease_pathogenesis:_what_have_we_learnt_in_the_past_10_years L2 - http://www.wjgnet.com/1007-9327/full/v20/i5/1192.htm DB - PRIME DP - Unbound Medicine ER -