Tags

Type your tag names separated by a space and hit enter

Extensive protein hydrolysate formula effectively reduces regurgitation in infants with positive and negative challenge tests for cow's milk allergy.
Acta Paediatr 2014; 103(6):e243-50AP

Abstract

AIM

Cow's milk protein allergy (CMPA) is treated using an elimination diet with an extensive protein hydrolysate. We explored whether a thickened or nonthickened version was best for infants with suspected CMPA, which commonly causes regurgitation/vomiting.

METHODS

Diagnosis of CMPA was based on a positive challenge test. We compared the efficacy of two casein extensive hydrolysates (eCH), a nonthickened version (NT-eCH) and a thickened version (T-eCH), using a symptom-based score covering regurgitation, crying, stool consistency, eczema, urticarial and respiratory symptoms.

RESULTS

A challenge was performed in 52/72 infants with suspected CMPA and was positive in 65.4%. All confirmed CMPA cases tolerated eCH. The symptom-based score decreased significantly in all infants within a month, and the highest reduction was in those with confirmed CMPA. Regurgitation was reduced in all infants (6.4 ± 3.2-2.8 ± 2.9, p < 0.001), but fell more with the T-eCH (-4.2 ± 3.2 regurgitations/day vs. -3.0 ± 4.5, ns), especially in infants with a negative challenge (-3.9 ± 4.0 vs. -1.9 ± 3.4, ns).

CONCLUSION

eCH fulfilled the criteria for a hypoallergenic formula, and the NT-eCH and T-eCH formulas both reduced CMPA symptoms. The symptom-based score is useful for evaluating how effective dietary treatments are for CMPA.

Authors+Show Affiliations

Department of Paediatrics, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24575806

Citation

Vandenplas, Y, et al. "Extensive Protein Hydrolysate Formula Effectively Reduces Regurgitation in Infants With Positive and Negative Challenge Tests for Cow's Milk Allergy." Acta Paediatrica (Oslo, Norway : 1992), vol. 103, no. 6, 2014, pp. e243-50.
Vandenplas Y, De Greef E, ALLAR study group. Extensive protein hydrolysate formula effectively reduces regurgitation in infants with positive and negative challenge tests for cow's milk allergy. Acta Paediatr. 2014;103(6):e243-50.
Vandenplas, Y., & De Greef, E. (2014). Extensive protein hydrolysate formula effectively reduces regurgitation in infants with positive and negative challenge tests for cow's milk allergy. Acta Paediatrica (Oslo, Norway : 1992), 103(6), pp. e243-50. doi:10.1111/apa.12615.
Vandenplas Y, De Greef E, ALLAR study group. Extensive Protein Hydrolysate Formula Effectively Reduces Regurgitation in Infants With Positive and Negative Challenge Tests for Cow's Milk Allergy. Acta Paediatr. 2014;103(6):e243-50. PubMed PMID: 24575806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extensive protein hydrolysate formula effectively reduces regurgitation in infants with positive and negative challenge tests for cow's milk allergy. AU - Vandenplas,Y, AU - De Greef,E, AU - ,, Y1 - 2014/03/31/ PY - 2013/12/05/received PY - 2014/01/13/revised PY - 2014/02/24/accepted PY - 2014/3/1/entrez PY - 2014/3/1/pubmed PY - 2015/1/13/medline KW - (Extensive) hydrolysate KW - Cow's milk protein allergy KW - Infant nutrition SP - e243 EP - 50 JF - Acta paediatrica (Oslo, Norway : 1992) JO - Acta Paediatr. VL - 103 IS - 6 N2 - AIM: Cow's milk protein allergy (CMPA) is treated using an elimination diet with an extensive protein hydrolysate. We explored whether a thickened or nonthickened version was best for infants with suspected CMPA, which commonly causes regurgitation/vomiting. METHODS: Diagnosis of CMPA was based on a positive challenge test. We compared the efficacy of two casein extensive hydrolysates (eCH), a nonthickened version (NT-eCH) and a thickened version (T-eCH), using a symptom-based score covering regurgitation, crying, stool consistency, eczema, urticarial and respiratory symptoms. RESULTS: A challenge was performed in 52/72 infants with suspected CMPA and was positive in 65.4%. All confirmed CMPA cases tolerated eCH. The symptom-based score decreased significantly in all infants within a month, and the highest reduction was in those with confirmed CMPA. Regurgitation was reduced in all infants (6.4 ± 3.2-2.8 ± 2.9, p < 0.001), but fell more with the T-eCH (-4.2 ± 3.2 regurgitations/day vs. -3.0 ± 4.5, ns), especially in infants with a negative challenge (-3.9 ± 4.0 vs. -1.9 ± 3.4, ns). CONCLUSION: eCH fulfilled the criteria for a hypoallergenic formula, and the NT-eCH and T-eCH formulas both reduced CMPA symptoms. The symptom-based score is useful for evaluating how effective dietary treatments are for CMPA. SN - 1651-2227 UR - https://www.unboundmedicine.com/medline/citation/24575806/Extensive_protein_hydrolysate_formula_effectively_reduces_regurgitation_in_infants_with_positive_and_negative_challenge_tests_for_cow's_milk_allergy_ L2 - https://doi.org/10.1111/apa.12615 DB - PRIME DP - Unbound Medicine ER -