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Parental age at delivery and a man's semen quality.
Hum Reprod. 2014 May; 29(5):1097-102.HR

Abstract

STUDY QUESTION

Is parental age at delivery associated with a man's semen quality?

SUMMARY ANSWER

In this large register-based study both mother's and father's age are found to have minimal effects on semen quality in men.

WHAT IS KNOWN ALREADY

Both maternal and paternal age have been associated with a range of adverse health effects in the offspring. Given the varied health effects of parental age upon offspring, and the sensitivity of genital development to external factors, it is plausible that the age of a man's mother and father at conception may impact his reproductive health. To our knowledge this is the first examination of the effects of parental age on semen quality.

STUDY DESIGN, SIZE, DURATION

A retrospective cohort study of 10 965 men with semen data and parental data.

PARTICIPANTS/MATERIALS, SETTING, METHODS

The study was based on Danish men referred to the Copenhagen Sperm Analysis Laboratory due to infertility in their partnership. Men born from 1960 and delivering a semen sample until year 2000 were included. The men were linked to the Danish Civil Registration System to obtain information on parent's age at delivery. Logistic regression analyses were used to calculate odds ratios and 95% confidence intervals for impaired semen quality. Linear regression analyses were used to examine a relationship between semen parameters and paternal age.

MAIN RESULTS AND THE ROLE OF CHANCE

There were no convincing effect of either mother's or father's age on a man's semen quality. As no trends were noted, the few statistically significant results are likely attributable to chance.

LIMITATIONS, REASONS FOR CAUTION

Information regarding individual subject characteristics which may impact sperm production (i.e. smoking, BMI) were not available. While our sample size was large, we cannot exclude the possibility that a trend may have been identified with a still larger sample. In addition, the Danish Civil Registration System is merely administrative and hence does not discriminate between biological and adopted children. However, the low rate of adoption (≈2%) suggests that misclassification would have a minimal impact. The men were all referred to the laboratory for infertility problems in their partnership and, therefore, do not represent the general population. We, however, compared semen quality among men within the cohort, and it is therefore less important whether they, in fact, represent the general population.

WIDER IMPLICATIONS OF THE FINDINGS

The current study found no link between parental age and a son's semen quality, suggesting other factors may explain recent impairments in men's reproductive health.

STUDY FUNDING/COMPETING INTEREST(S)

This work was supported by the Hans and Nora Buchard's Fund and the Kirsten and Freddy Johansen's Fund. No competing interests.

TRIAL REGISTRATION NUMBER

Not relevant.

Authors+Show Affiliations

University Department of Growth and Reproduction, Rigshospitalet, Copenhagen 2100, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24578474

Citation

Priskorn, Lærke, et al. "Parental Age at Delivery and a Man's Semen Quality." Human Reproduction (Oxford, England), vol. 29, no. 5, 2014, pp. 1097-102.
Priskorn L, Jensen TK, Lindahl-Jacobsen R, et al. Parental age at delivery and a man's semen quality. Hum Reprod. 2014;29(5):1097-102.
Priskorn, L., Jensen, T. K., Lindahl-Jacobsen, R., Skakkebæk, N. E., Bostofte, E., & Eisenberg, M. L. (2014). Parental age at delivery and a man's semen quality. Human Reproduction (Oxford, England), 29(5), 1097-102. https://doi.org/10.1093/humrep/deu039
Priskorn L, et al. Parental Age at Delivery and a Man's Semen Quality. Hum Reprod. 2014;29(5):1097-102. PubMed PMID: 24578474.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parental age at delivery and a man's semen quality. AU - Priskorn,Lærke, AU - Jensen,Tina K, AU - Lindahl-Jacobsen,Rune, AU - Skakkebæk,Niels E, AU - Bostofte,Erik, AU - Eisenberg,Michael L, Y1 - 2014/02/26/ PY - 2014/3/1/entrez PY - 2014/3/1/pubmed PY - 2014/12/17/medline KW - fertility KW - parental age KW - reproduction KW - semen SP - 1097 EP - 102 JF - Human reproduction (Oxford, England) JO - Hum Reprod VL - 29 IS - 5 N2 - STUDY QUESTION: Is parental age at delivery associated with a man's semen quality? SUMMARY ANSWER: In this large register-based study both mother's and father's age are found to have minimal effects on semen quality in men. WHAT IS KNOWN ALREADY: Both maternal and paternal age have been associated with a range of adverse health effects in the offspring. Given the varied health effects of parental age upon offspring, and the sensitivity of genital development to external factors, it is plausible that the age of a man's mother and father at conception may impact his reproductive health. To our knowledge this is the first examination of the effects of parental age on semen quality. STUDY DESIGN, SIZE, DURATION: A retrospective cohort study of 10 965 men with semen data and parental data. PARTICIPANTS/MATERIALS, SETTING, METHODS: The study was based on Danish men referred to the Copenhagen Sperm Analysis Laboratory due to infertility in their partnership. Men born from 1960 and delivering a semen sample until year 2000 were included. The men were linked to the Danish Civil Registration System to obtain information on parent's age at delivery. Logistic regression analyses were used to calculate odds ratios and 95% confidence intervals for impaired semen quality. Linear regression analyses were used to examine a relationship between semen parameters and paternal age. MAIN RESULTS AND THE ROLE OF CHANCE: There were no convincing effect of either mother's or father's age on a man's semen quality. As no trends were noted, the few statistically significant results are likely attributable to chance. LIMITATIONS, REASONS FOR CAUTION: Information regarding individual subject characteristics which may impact sperm production (i.e. smoking, BMI) were not available. While our sample size was large, we cannot exclude the possibility that a trend may have been identified with a still larger sample. In addition, the Danish Civil Registration System is merely administrative and hence does not discriminate between biological and adopted children. However, the low rate of adoption (≈2%) suggests that misclassification would have a minimal impact. The men were all referred to the laboratory for infertility problems in their partnership and, therefore, do not represent the general population. We, however, compared semen quality among men within the cohort, and it is therefore less important whether they, in fact, represent the general population. WIDER IMPLICATIONS OF THE FINDINGS: The current study found no link between parental age and a son's semen quality, suggesting other factors may explain recent impairments in men's reproductive health. STUDY FUNDING/COMPETING INTEREST(S): This work was supported by the Hans and Nora Buchard's Fund and the Kirsten and Freddy Johansen's Fund. No competing interests. TRIAL REGISTRATION NUMBER: Not relevant. SN - 1460-2350 UR - https://www.unboundmedicine.com/medline/citation/24578474/Parental_age_at_delivery_and_a_man's_semen_quality_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/deu039 DB - PRIME DP - Unbound Medicine ER -