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[Experimental study on functional connection between the lung and large intestine meridians in the rat: cross-talk between the lung and large intestine meridians].
Zhen Ci Yan Jiu. 2013 Dec; 38(6):453-8.ZC

Abstract

OBJECTIVE

According to the theory of traditional Chinese medicine about "close association between the lung and the large intestine", the present study was designed to investigate the functional relationship between the Lung and Large Intestine Meridians and the colorectum by using electrophysiological methods.

METHODS

A total of 40 SD rats were used in the present study. Under anesthesia, the cardiopulmonary branch of the left sympathetic nerve (CPSN) was separated for recording the electrical activities with a pair of platinum wire electrodes. Intra-colorectal pressure was recorded using a water-balloon inserted into the anus and connected to a pressure-transducer for observing rectocolonic pressure changes (mobility). Electroacupuncture (EA) stimulation was applied to bilateral "Taiyuan" (LU 9)- "Jingqu" (LU 8) of the Lung Meridian, "Yangxi" (LI 5)-"Pianli" (LI 6) of the Large Intestine Meridian, and "Shangjuxu" (ST 37)-"Zusanli" (ST 36) of the Stomach Meridian, respectively. Colorectal distension (CRD, visceral pain stimulation, 60 mmHg and 80 mmHg) was performed using an air-balloon for observing its influence on EA stimulation of LU 9- LU 8 induced changes of electrical activities of CPSN.

RESULTS

Under anesthesia conditions, no spontaneous electrical activities of the CPSN were found in rats. After EA stimulation (3 times of the threshold intensity) of the bilateral "Taiyuan" (LU 9)- "Jingqu" (LU 8) of the Lung Meridian, and "Yangxi" (LI 5)-"Pianli" (LI 6) of the Large Intestine Meridian, the evoked discharge numbers of the cardiopulmonary sympathetic nerve were (11.26 +/- 2.34) and (10.73 +/- 2.62) spikes, respectively, without significant differences between the two groups (P > 0.05). Compared with pre-stimulation, the colorectal motility (amplitudes of the intra-colorectal pressure waves) was obviously increased following EA stimulation of LU 9-LU 8 of the Lung Meridian, LI 5-LI 6 of the Large Intestine Meridian and "Shangjuxu" (ST 37)-"Zusanli" (ST 36) , Lower-Ho (Sea) acupoints of the Large Intestine Meridian (P < 0.05). After CRD stimulation at 60 mmHg and 80 mmHg, the LU 9- LU 8-stimulation evoked discharge rates of CPSN were reduced by 43.46% and 67.42%, respectively.

CONCLUSION

EA stimulation of LU 9- LU 8 of the Lung Meridian and LI 5-LI 6 of the Large Intestine Meridian can activate discharges of CPSN, and increase the colorectal motility in the rat. CRD stimulation inhibits the activated effect of EA on electrical activities of CPSN. These results show a functional communication or cross-talk between the lung and the colorectum.

Authors+Show Affiliations

Institute of Acu-moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100007.Institute of Acu-moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.Institute of Acu-moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

24579359

Citation

Qin, Qing-guang, et al. "[Experimental Study On Functional Connection Between the Lung and Large Intestine Meridians in the Rat: Cross-talk Between the Lung and Large Intestine Meridians]." Zhen Ci Yan Jiu = Acupuncture Research, vol. 38, no. 6, 2013, pp. 453-8.
Qin QG, Zhao JP, Zhu B, et al. [Experimental study on functional connection between the lung and large intestine meridians in the rat: cross-talk between the lung and large intestine meridians]. Zhen Ci Yan Jiu. 2013;38(6):453-8.
Qin, Q. G., Zhao, J. P., Zhu, B., & Rong, P. J. (2013). [Experimental study on functional connection between the lung and large intestine meridians in the rat: cross-talk between the lung and large intestine meridians]. Zhen Ci Yan Jiu = Acupuncture Research, 38(6), 453-8.
Qin QG, et al. [Experimental Study On Functional Connection Between the Lung and Large Intestine Meridians in the Rat: Cross-talk Between the Lung and Large Intestine Meridians]. Zhen Ci Yan Jiu. 2013;38(6):453-8. PubMed PMID: 24579359.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Experimental study on functional connection between the lung and large intestine meridians in the rat: cross-talk between the lung and large intestine meridians]. AU - Qin,Qing-guang, AU - Zhao,Ji-ping, AU - Zhu,Bing, AU - Rong,Pei-jing, PY - 2014/3/4/entrez PY - 2014/3/4/pubmed PY - 2014/4/2/medline SP - 453 EP - 8 JF - Zhen ci yan jiu = Acupuncture research JO - Zhen Ci Yan Jiu VL - 38 IS - 6 N2 - OBJECTIVE: According to the theory of traditional Chinese medicine about "close association between the lung and the large intestine", the present study was designed to investigate the functional relationship between the Lung and Large Intestine Meridians and the colorectum by using electrophysiological methods. METHODS: A total of 40 SD rats were used in the present study. Under anesthesia, the cardiopulmonary branch of the left sympathetic nerve (CPSN) was separated for recording the electrical activities with a pair of platinum wire electrodes. Intra-colorectal pressure was recorded using a water-balloon inserted into the anus and connected to a pressure-transducer for observing rectocolonic pressure changes (mobility). Electroacupuncture (EA) stimulation was applied to bilateral "Taiyuan" (LU 9)- "Jingqu" (LU 8) of the Lung Meridian, "Yangxi" (LI 5)-"Pianli" (LI 6) of the Large Intestine Meridian, and "Shangjuxu" (ST 37)-"Zusanli" (ST 36) of the Stomach Meridian, respectively. Colorectal distension (CRD, visceral pain stimulation, 60 mmHg and 80 mmHg) was performed using an air-balloon for observing its influence on EA stimulation of LU 9- LU 8 induced changes of electrical activities of CPSN. RESULTS: Under anesthesia conditions, no spontaneous electrical activities of the CPSN were found in rats. After EA stimulation (3 times of the threshold intensity) of the bilateral "Taiyuan" (LU 9)- "Jingqu" (LU 8) of the Lung Meridian, and "Yangxi" (LI 5)-"Pianli" (LI 6) of the Large Intestine Meridian, the evoked discharge numbers of the cardiopulmonary sympathetic nerve were (11.26 +/- 2.34) and (10.73 +/- 2.62) spikes, respectively, without significant differences between the two groups (P > 0.05). Compared with pre-stimulation, the colorectal motility (amplitudes of the intra-colorectal pressure waves) was obviously increased following EA stimulation of LU 9-LU 8 of the Lung Meridian, LI 5-LI 6 of the Large Intestine Meridian and "Shangjuxu" (ST 37)-"Zusanli" (ST 36) , Lower-Ho (Sea) acupoints of the Large Intestine Meridian (P < 0.05). After CRD stimulation at 60 mmHg and 80 mmHg, the LU 9- LU 8-stimulation evoked discharge rates of CPSN were reduced by 43.46% and 67.42%, respectively. CONCLUSION: EA stimulation of LU 9- LU 8 of the Lung Meridian and LI 5-LI 6 of the Large Intestine Meridian can activate discharges of CPSN, and increase the colorectal motility in the rat. CRD stimulation inhibits the activated effect of EA on electrical activities of CPSN. These results show a functional communication or cross-talk between the lung and the colorectum. SN - 1000-0607 UR - https://www.unboundmedicine.com/medline/citation/24579359/[Experimental_study_on_functional_connection_between_the_lung_and_large_intestine_meridians_in_the_rat:_cross_talk_between_the_lung_and_large_intestine_meridians]_ DB - PRIME DP - Unbound Medicine ER -