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[Effects of electroacupuncture stimulation of "Neiguan" (PC 6) and "Shenmen" (HT7) on contents of 5-hydroxytryptamine in hypothalamic paraventricular nucleus region and serum in hyperlipidemia rats with acute myocardial infarction].
Zhen Ci Yan Jiu. 2013 Dec; 38(6):482-7.ZC

Abstract

OBJECTIVE

To observe the effects of electroacupuncture (EA) stimulation of "Neiguan"(PC 6) and "Shenmen" (HT 7) on 5-hydroxytryptamine (5-HT) levels in the paraventricular nucleus (PVN) region of hypothalamus and serum in hyperlipidemia rats with acute myocardial infarction (AMI).

METHODS

A total of 80 SD rats with hyperlipidemia were used in the present study. Among them, 20 rats were randomly selected to be the sham-operation group, and the rest 60 cases were used to make the AMI model by occlusion of the anterior descending branch of the left coronary artery. The 60 rats who were identified to be successful in AMI were randomly divided into model group, EA-PC 6 group and EA-HT 7 group (20 rats/group). EA (2 Hz, 2 mA) was applied to bilateral PC 6 and HT 7 for 20 min, once daily for 5 days. The contents of 5-HT of hypothalamic PVN region and serum were examined by enzyme linked immunosorbent assay (ELISA) and radioimmunoassay, respectively.

RESULTS

Following AMI, marked myocardial injury (swelling, breakage, disappearance of local transverse striations and necrosis of myocytes) with infiltration of neutrophil granulocytes was found in the model group, while in both EA-PC 6 group and EA-HT 7 group, moderate swelling (no breakage) of fewer myocardial fibers with mild infiltration of neutrophil granulocytes was found, indicating a marked improvement of myocardial injury after EA treatment. Compared with the sham-operation group, the content of 5-HT was obviously decreased in the hypothalamic PVN region and significantly increased in serum in the model group (P < 0.01). After EA intervention, the content of 5-HT was considerably up-regulated in the hypothalamic PVN region and apparently down-regulated in serum in both EA-PC 6 and EA-HT 7 groups in comparison with the model group (P < 0.01). No significant differences were found between EA-PC 6 and EA-HT 7 groups in regulating hypothalamic and serum 5-HT levels (P > 0.05).

CONCLUSION

EA stimulation of both PC 6 and HT 7 can relieve acute ischemic injury of the myocardium in hyperlipidemia rats, which is probably partially related to its effect in promoting the release of 5-HT from the hypothalamic PVN region.

Authors+Show Affiliations

Institute of Acupuncture and Meridian, Anhui College of Chinese Medicine, Hefei 230038, China.Institute of Acupuncture and Meridian, Anhui College of Chinese Medicine, Hefei 230038, China.Institute of Acupuncture and Meridian, Anhui College of Chinese Medicine, Hefei 230038, China.Institute of Acupuncture and Meridian, Anhui College of Chinese Medicine, Hefei 230038, China.Institute of Acupuncture and Meridian, Anhui College of Chinese Medicine, Hefei 230038, China.Institute of Acupuncture and Meridian, Anhui College of Chinese Medicine, Hefei 230038, China.

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

24579363

Citation

Wu, Zi-jian, et al. "[Effects of Electroacupuncture Stimulation of "Neiguan" (PC 6) and "Shenmen" (HT7) On Contents of 5-hydroxytryptamine in Hypothalamic Paraventricular Nucleus Region and Serum in Hyperlipidemia Rats With Acute Myocardial Infarction]." Zhen Ci Yan Jiu = Acupuncture Research, vol. 38, no. 6, 2013, pp. 482-7.
Wu ZJ, Cai RL, He L, et al. [Effects of electroacupuncture stimulation of "Neiguan" (PC 6) and "Shenmen" (HT7) on contents of 5-hydroxytryptamine in hypothalamic paraventricular nucleus region and serum in hyperlipidemia rats with acute myocardial infarction]. Zhen Ci Yan Jiu. 2013;38(6):482-7.
Wu, Z. J., Cai, R. L., He, L., Ma, Y., Hu, W. B., & Wang, K. M. (2013). [Effects of electroacupuncture stimulation of "Neiguan" (PC 6) and "Shenmen" (HT7) on contents of 5-hydroxytryptamine in hypothalamic paraventricular nucleus region and serum in hyperlipidemia rats with acute myocardial infarction]. Zhen Ci Yan Jiu = Acupuncture Research, 38(6), 482-7.
Wu ZJ, et al. [Effects of Electroacupuncture Stimulation of "Neiguan" (PC 6) and "Shenmen" (HT7) On Contents of 5-hydroxytryptamine in Hypothalamic Paraventricular Nucleus Region and Serum in Hyperlipidemia Rats With Acute Myocardial Infarction]. Zhen Ci Yan Jiu. 2013;38(6):482-7. PubMed PMID: 24579363.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of electroacupuncture stimulation of "Neiguan" (PC 6) and "Shenmen" (HT7) on contents of 5-hydroxytryptamine in hypothalamic paraventricular nucleus region and serum in hyperlipidemia rats with acute myocardial infarction]. AU - Wu,Zi-jian, AU - Cai,Rong-lin, AU - He,Lu, AU - Ma,Yong, AU - Hu,Wu-bin, AU - Wang,Ke-ming, PY - 2014/3/4/entrez PY - 2014/3/4/pubmed PY - 2014/4/2/medline SP - 482 EP - 7 JF - Zhen ci yan jiu = Acupuncture research JO - Zhen Ci Yan Jiu VL - 38 IS - 6 N2 - OBJECTIVE: To observe the effects of electroacupuncture (EA) stimulation of "Neiguan"(PC 6) and "Shenmen" (HT 7) on 5-hydroxytryptamine (5-HT) levels in the paraventricular nucleus (PVN) region of hypothalamus and serum in hyperlipidemia rats with acute myocardial infarction (AMI). METHODS: A total of 80 SD rats with hyperlipidemia were used in the present study. Among them, 20 rats were randomly selected to be the sham-operation group, and the rest 60 cases were used to make the AMI model by occlusion of the anterior descending branch of the left coronary artery. The 60 rats who were identified to be successful in AMI were randomly divided into model group, EA-PC 6 group and EA-HT 7 group (20 rats/group). EA (2 Hz, 2 mA) was applied to bilateral PC 6 and HT 7 for 20 min, once daily for 5 days. The contents of 5-HT of hypothalamic PVN region and serum were examined by enzyme linked immunosorbent assay (ELISA) and radioimmunoassay, respectively. RESULTS: Following AMI, marked myocardial injury (swelling, breakage, disappearance of local transverse striations and necrosis of myocytes) with infiltration of neutrophil granulocytes was found in the model group, while in both EA-PC 6 group and EA-HT 7 group, moderate swelling (no breakage) of fewer myocardial fibers with mild infiltration of neutrophil granulocytes was found, indicating a marked improvement of myocardial injury after EA treatment. Compared with the sham-operation group, the content of 5-HT was obviously decreased in the hypothalamic PVN region and significantly increased in serum in the model group (P < 0.01). After EA intervention, the content of 5-HT was considerably up-regulated in the hypothalamic PVN region and apparently down-regulated in serum in both EA-PC 6 and EA-HT 7 groups in comparison with the model group (P < 0.01). No significant differences were found between EA-PC 6 and EA-HT 7 groups in regulating hypothalamic and serum 5-HT levels (P > 0.05). CONCLUSION: EA stimulation of both PC 6 and HT 7 can relieve acute ischemic injury of the myocardium in hyperlipidemia rats, which is probably partially related to its effect in promoting the release of 5-HT from the hypothalamic PVN region. SN - 1000-0607 UR - https://www.unboundmedicine.com/medline/citation/24579363/[Effects_of_electroacupuncture_stimulation_of_"Neiguan"__PC_6__and_"Shenmen"__HT7__on_contents_of_5_hydroxytryptamine_in_hypothalamic_paraventricular_nucleus_region_and_serum_in_hyperlipidemia_rats_with_acute_myocardial_infarction]_ L2 - https://medlineplus.gov/heartattack.html DB - PRIME DP - Unbound Medicine ER -