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Anti-diabetic effect of a combination of andrographolide-enriched extract of Andrographis paniculata (Burm f.) Nees and asiaticoside-enriched extract of Centella asiatica L. in high fructose-fat fed rats.
Indian J Exp Biol. 2013 Dec; 51(12):1101-8.IJ

Abstract

Traditionally, a combination of medicinal plants is commonly used for lowering blood glucose in diabetic patients in order to provide additional benefits of the single drug. A. paniculata and C. asiatica are two traditional medicines form South Asian and Southeast Asain countries consumed by people for treating daibates mellitus and its complications. Hyperglycemia in the rats was stimulated by high fructose-fat diet that consists of 36% fructose, 15% lard, and 5% egg yolks in 0.36 g/200 g body weight for 70 days. The rats were orally administered with the combination of andrographolide-enriched extract of A. paniculata (AEEAP) leaves and asiaticoside-enriched extract of C. asiatica (AEECA) herbs from day 70 for 7 days. Antidiabetic activity was evaluated by estimating mainly the blood glucose levels and other parameters such as HDL, LDL, cholesterol and triglyceride. The results showed that combination at the ratio of 70:30 exhibited a promosing antidiabetic effect in high-fat-fructose-fed rat, and exhibited sinergistic effects on blood cholesterol and HDL levels. It can be concluded that its antidiabetic effect was better than that of single treatment of AEEAP or AEECA. That combination was also potential to develop as a blood glucose-lowering agent for diabetic patients.

Authors+Show Affiliations

Nugroho AE
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Jogjakarta, Indonesia, 55281. agungendronugroho@yahoo.com
Lindawati NY
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Jogjakarta, Indonesia, 55281.
Herlyanti K
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Jogjakarta, Indonesia, 55281.
Widyastuti L
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Jogjakarta, Indonesia, 55281.
Pramono S
Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Gadjah Mada, Jogjakarta, Indonesia, 55281.

MeSH

Andrographis paniculataAnimalsCentellaDiabetes Mellitus, ExperimentalDiet, High-FatDiterpenesDrug CombinationsDrug SynergismFructoseHumansHypoglycemic AgentsPhytotherapyPlant ExtractsRatsTriterpenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24579376

Citation

Nugroho, Agung Endro, et al. "Anti-diabetic Effect of a Combination of Andrographolide-enriched Extract of Andrographis Paniculata (Burm F.) Nees and Asiaticoside-enriched Extract of Centella Asiatica L. in High Fructose-fat Fed Rats." Indian Journal of Experimental Biology, vol. 51, no. 12, 2013, pp. 1101-8.
Nugroho AE, Lindawati NY, Herlyanti K, et al. Anti-diabetic effect of a combination of andrographolide-enriched extract of Andrographis paniculata (Burm f.) Nees and asiaticoside-enriched extract of Centella asiatica L. in high fructose-fat fed rats. Indian J Exp Biol. 2013;51(12):1101-8.
Nugroho, A. E., Lindawati, N. Y., Herlyanti, K., Widyastuti, L., & Pramono, S. (2013). Anti-diabetic effect of a combination of andrographolide-enriched extract of Andrographis paniculata (Burm f.) Nees and asiaticoside-enriched extract of Centella asiatica L. in high fructose-fat fed rats. Indian Journal of Experimental Biology, 51(12), 1101-8.
Nugroho AE, et al. Anti-diabetic Effect of a Combination of Andrographolide-enriched Extract of Andrographis Paniculata (Burm F.) Nees and Asiaticoside-enriched Extract of Centella Asiatica L. in High Fructose-fat Fed Rats. Indian J Exp Biol. 2013;51(12):1101-8. PubMed PMID: 24579376.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-diabetic effect of a combination of andrographolide-enriched extract of Andrographis paniculata (Burm f.) Nees and asiaticoside-enriched extract of Centella asiatica L. in high fructose-fat fed rats. AU - Nugroho,Agung Endro, AU - Lindawati,Novena Yety, AU - Herlyanti,Kyky, AU - Widyastuti,Lina, AU - Pramono,Suwidjiyo, PY - 2014/3/4/entrez PY - 2014/3/4/pubmed PY - 2014/3/29/medline SP - 1101 EP - 8 JF - Indian journal of experimental biology JO - Indian J Exp Biol VL - 51 IS - 12 N2 - Traditionally, a combination of medicinal plants is commonly used for lowering blood glucose in diabetic patients in order to provide additional benefits of the single drug. A. paniculata and C. asiatica are two traditional medicines form South Asian and Southeast Asain countries consumed by people for treating daibates mellitus and its complications. Hyperglycemia in the rats was stimulated by high fructose-fat diet that consists of 36% fructose, 15% lard, and 5% egg yolks in 0.36 g/200 g body weight for 70 days. The rats were orally administered with the combination of andrographolide-enriched extract of A. paniculata (AEEAP) leaves and asiaticoside-enriched extract of C. asiatica (AEECA) herbs from day 70 for 7 days. Antidiabetic activity was evaluated by estimating mainly the blood glucose levels and other parameters such as HDL, LDL, cholesterol and triglyceride. The results showed that combination at the ratio of 70:30 exhibited a promosing antidiabetic effect in high-fat-fructose-fed rat, and exhibited sinergistic effects on blood cholesterol and HDL levels. It can be concluded that its antidiabetic effect was better than that of single treatment of AEEAP or AEECA. That combination was also potential to develop as a blood glucose-lowering agent for diabetic patients. SN - 0019-5189 UR - https://www.unboundmedicine.com/medline/citation/24579376/Anti_diabetic_effect_of_a_combination_of_andrographolide_enriched_extract_of_Andrographis_paniculata__Burm_f___Nees_and_asiaticoside_enriched_extract_of_Centella_asiatica_L__in_high_fructose_fat_fed_rats_ DB - PRIME DP - Unbound Medicine ER -