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Numerical analysis of a red blood cell flowing through a thin micropore.

Abstract

Red blood cell (RBC) deformability plays a key role in microcirculation, especially in vessels that have diameters even smaller than the nominal cell size. In this study, we numerically investigate the dynamics of an RBC in a thin micropore. The RBC is modeled as a capsule with a thin hyperelastic membrane. In a numerical simulation, we employ a boundary element method for fluid mechanics and a finite element method for membrane mechanics. The resulting RBC deformation towards the flow direction is suppressed considerably by increased cytoplasm viscosity, whereas the gap between the cell membrane and solid wall becomes smaller with higher cytoplasm viscosity. We also measure the transit time of the RBC and find that nondimensional transit time increases nonlinearly with respect to the viscosity ratio, whereas it is invariant to the capillary number. In conclusion, cytoplasmic viscosity plays a key role in the dynamics of an RBC in a thin pore. The results of this study will be useful for designing a microfluidic device to measure cytoplasmic viscosity.

Authors+Show Affiliations

Department of Bioengineering and Robotics, Tohoku University, Aoba 6-6-01, Aramaki, Sendai, Miyagi, Japan.Department of Bioengineering and Robotics, Tohoku University, Aoba 6-6-01, Aramaki, Sendai, Miyagi, Japan.Department of Bioengineering and Robotics, Tohoku University, Aoba 6-6-01, Aramaki, Sendai, Miyagi, Japan.Department of Bioengineering and Robotics, Tohoku University, Aoba 6-6-01, Aramaki, Sendai, Miyagi, Japan.Department of Bioengineering and Robotics, Tohoku University, Aoba 6-6-01, Aramaki, Sendai, Miyagi, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24580321

Citation

Omori, Toshihiro, et al. "Numerical Analysis of a Red Blood Cell Flowing Through a Thin Micropore." Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics, vol. 89, no. 1, 2014, p. 013008.
Omori T, Hosaka H, Imai Y, et al. Numerical analysis of a red blood cell flowing through a thin micropore. Phys Rev E Stat Nonlin Soft Matter Phys. 2014;89(1):013008.
Omori, T., Hosaka, H., Imai, Y., Yamaguchi, T., & Ishikawa, T. (2014). Numerical analysis of a red blood cell flowing through a thin micropore. Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics, 89(1), p. 013008.
Omori T, et al. Numerical Analysis of a Red Blood Cell Flowing Through a Thin Micropore. Phys Rev E Stat Nonlin Soft Matter Phys. 2014;89(1):013008. PubMed PMID: 24580321.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Numerical analysis of a red blood cell flowing through a thin micropore. AU - Omori,Toshihiro, AU - Hosaka,Haruki, AU - Imai,Yohsuke, AU - Yamaguchi,Takami, AU - Ishikawa,Takuji, Y1 - 2014/01/13/ PY - 2013/10/26/received PY - 2014/3/4/entrez PY - 2014/3/4/pubmed PY - 2015/4/29/medline SP - 013008 EP - 013008 JF - Physical review. E, Statistical, nonlinear, and soft matter physics JO - Phys Rev E Stat Nonlin Soft Matter Phys VL - 89 IS - 1 N2 - Red blood cell (RBC) deformability plays a key role in microcirculation, especially in vessels that have diameters even smaller than the nominal cell size. In this study, we numerically investigate the dynamics of an RBC in a thin micropore. The RBC is modeled as a capsule with a thin hyperelastic membrane. In a numerical simulation, we employ a boundary element method for fluid mechanics and a finite element method for membrane mechanics. The resulting RBC deformation towards the flow direction is suppressed considerably by increased cytoplasm viscosity, whereas the gap between the cell membrane and solid wall becomes smaller with higher cytoplasm viscosity. We also measure the transit time of the RBC and find that nondimensional transit time increases nonlinearly with respect to the viscosity ratio, whereas it is invariant to the capillary number. In conclusion, cytoplasmic viscosity plays a key role in the dynamics of an RBC in a thin pore. The results of this study will be useful for designing a microfluidic device to measure cytoplasmic viscosity. SN - 1550-2376 UR - https://www.unboundmedicine.com/medline/citation/24580321/Numerical_analysis_of_a_red_blood_cell_flowing_through_a_thin_micropore_ DB - PRIME DP - Unbound Medicine ER -