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Systematic review of the risk of Parkinson's disease after mild traumatic brain injury: results of the International Collaboration on Mild Traumatic Brain Injury Prognosis.
Arch Phys Med Rehabil. 2014 Mar; 95(3 Suppl):S238-44.AP

Abstract

OBJECTIVE

To synthesize the best available evidence on the risk of Parkinson's disease (PD) after mild traumatic brain injury (MTBI).

DATA SOURCES

MEDLINE and other databases were searched (1990-2012) with terms including "craniocerebral trauma" and "parkinsonian disorders." Reference lists of eligible articles and relevant systematic reviews and meta-analyses were also searched.

STUDY SELECTION

Controlled clinical trials, cohort studies, and case-control studies were selected according to predefined criteria. Studies had to have a minimum of 30 concussion cases.

DATA EXTRACTION

Eligible studies were critically appraised using a modification of the Scottish Intercollegiate Guidelines Network criteria. Two reviewers independently reviewed and extracted data from accepted studies into evidence tables.

DATA SYNTHESIS

Evidence was synthesized qualitatively according to modified Scottish Intercollegiate Guidelines Network criteria. Sixty-five studies were eligible and reviewed, and 5 of these with a low risk of bias were accepted as scientifically admissible and form the basis of our findings. Among these admissible studies, the definitions of MTBI were highly heterogeneous. One study found a significant positive association between MTBI and PD (odds ratio, 1.5; 95% confidence interval, 1.4-1.7). The estimated odds ratio decreased with increasing latency between MTBI and PD diagnosis, which suggests reverse causality. The other 4 studies did not find a significant association.

CONCLUSIONS

The best available evidence argues against an important causal association between MTBI and PD. There are few high-quality studies on this topic. Prospective studies of long duration would address the limitations of recall of head injury and the possibility of reverse causation.

Authors+Show Affiliations

Morton and Gloria Shulman Movement Disorders Centre, and the Edmond J. Safra Program in Parkinson's Research, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address: cmarras@uhnresearch.ca.Division of Health Care and Outcomes Research, Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Department of Health Sciences, Lakehead University, Thunder Bay, Ontario, Canada; Institute for Work and Health, Toronto, Ontario, Canada; Division of Human Sciences, Northern Ontario School of Medicine, Lakehead University, Thunder Bay, Ontario, Canada.Division of Health Care and Outcomes Research, Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.Centre for Addiction and Mental Health, Toronto, Ontario, Canada.Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada.Department of Clinical Sciences, Rehabilitation Medicine, Karolinska Institutet, Danderyd University Hospital, Stockholm, Sweden.Department of Clinical Sciences, Rehabilitation Medicine, Karolinska Institutet, Danderyd University Hospital, Stockholm, Sweden.Division of Health Care and Outcomes Research, Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada; Institute of Sports Science and Clinical Biomechanics, Faculty of Health, University of Southern Denmark, Odense, Denmark.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

24581909

Citation

Marras, Connie, et al. "Systematic Review of the Risk of Parkinson's Disease After Mild Traumatic Brain Injury: Results of the International Collaboration On Mild Traumatic Brain Injury Prognosis." Archives of Physical Medicine and Rehabilitation, vol. 95, no. 3 Suppl, 2014, pp. S238-44.
Marras C, Hincapié CA, Kristman VL, et al. Systematic review of the risk of Parkinson's disease after mild traumatic brain injury: results of the International Collaboration on Mild Traumatic Brain Injury Prognosis. Arch Phys Med Rehabil. 2014;95(3 Suppl):S238-44.
Marras, C., Hincapié, C. A., Kristman, V. L., Cancelliere, C., Soklaridis, S., Li, A., Borg, J., af Geijerstam, J. L., & Cassidy, J. D. (2014). Systematic review of the risk of Parkinson's disease after mild traumatic brain injury: results of the International Collaboration on Mild Traumatic Brain Injury Prognosis. Archives of Physical Medicine and Rehabilitation, 95(3 Suppl), S238-44. https://doi.org/10.1016/j.apmr.2013.08.298
Marras C, et al. Systematic Review of the Risk of Parkinson's Disease After Mild Traumatic Brain Injury: Results of the International Collaboration On Mild Traumatic Brain Injury Prognosis. Arch Phys Med Rehabil. 2014;95(3 Suppl):S238-44. PubMed PMID: 24581909.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Systematic review of the risk of Parkinson's disease after mild traumatic brain injury: results of the International Collaboration on Mild Traumatic Brain Injury Prognosis. AU - Marras,Connie, AU - Hincapié,Cesar A, AU - Kristman,Vicki L, AU - Cancelliere,Carol, AU - Soklaridis,Sophie, AU - Li,Alvin, AU - Borg,Jörgen, AU - af Geijerstam,Jean-Luc, AU - Cassidy,J David, PY - 2013/02/23/received PY - 2013/07/30/revised PY - 2013/08/08/accepted PY - 2014/3/4/entrez PY - 2014/3/4/pubmed PY - 2014/4/30/medline KW - Brain concussion KW - Parkinson's disease KW - Rehabilitation KW - Review, systematic SP - S238 EP - 44 JF - Archives of physical medicine and rehabilitation JO - Arch Phys Med Rehabil VL - 95 IS - 3 Suppl N2 - OBJECTIVE: To synthesize the best available evidence on the risk of Parkinson's disease (PD) after mild traumatic brain injury (MTBI). DATA SOURCES: MEDLINE and other databases were searched (1990-2012) with terms including "craniocerebral trauma" and "parkinsonian disorders." Reference lists of eligible articles and relevant systematic reviews and meta-analyses were also searched. STUDY SELECTION: Controlled clinical trials, cohort studies, and case-control studies were selected according to predefined criteria. Studies had to have a minimum of 30 concussion cases. DATA EXTRACTION: Eligible studies were critically appraised using a modification of the Scottish Intercollegiate Guidelines Network criteria. Two reviewers independently reviewed and extracted data from accepted studies into evidence tables. DATA SYNTHESIS: Evidence was synthesized qualitatively according to modified Scottish Intercollegiate Guidelines Network criteria. Sixty-five studies were eligible and reviewed, and 5 of these with a low risk of bias were accepted as scientifically admissible and form the basis of our findings. Among these admissible studies, the definitions of MTBI were highly heterogeneous. One study found a significant positive association between MTBI and PD (odds ratio, 1.5; 95% confidence interval, 1.4-1.7). The estimated odds ratio decreased with increasing latency between MTBI and PD diagnosis, which suggests reverse causality. The other 4 studies did not find a significant association. CONCLUSIONS: The best available evidence argues against an important causal association between MTBI and PD. There are few high-quality studies on this topic. Prospective studies of long duration would address the limitations of recall of head injury and the possibility of reverse causation. SN - 1532-821X UR - https://www.unboundmedicine.com/medline/citation/24581909/Systematic_review_of_the_risk_of_Parkinson's_disease_after_mild_traumatic_brain_injury:_results_of_the_International_Collaboration_on_Mild_Traumatic_Brain_Injury_Prognosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-9993(13)01071-X DB - PRIME DP - Unbound Medicine ER -