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Systematic review of the risk of dementia and chronic cognitive impairment after mild traumatic brain injury: results of the International Collaboration on Mild Traumatic Brain Injury Prognosis.
Arch Phys Med Rehabil. 2014 Mar; 95(3 Suppl):S245-56.AP

Abstract

OBJECTIVE

To synthesize the best available evidence regarding the risk of dementia and chronic cognitive impairment (CCI) after mild traumatic brain injury (MTBI).

DATA SOURCES

MEDLINE and other databases were searched (2001-2012) using a previously published search strategy and predefined criteria. Peer-reviewed reports in 6 languages were considered.

STUDY SELECTION

Systematic reviews, meta-analyses, randomized controlled trials, cohort studies, and case-control studies, with a minimum of 30 MTBI cases in subjects of any age, assessing the risk of dementia or CCI after MTBI were selected.

DATA EXTRACTION

Eligible studies were critically appraised using a modification of the Scottish Intercollegiate Guidelines Network criteria. Two reviewers independently reviewed each study and extracted data from accepted articles (ie, with a low risk of bias) into evidence tables.

DATA SYNTHESIS

Evidence from accepted studies was synthesized qualitatively according to modified Scottish Intercollegiate Guidelines Network criteria, and prognostic information was prioritized as exploratory or confirmatory according to design. Of 77,914 records screened, 299 articles were eligible and reviewed. Methodological quality was acceptable for 101 (34%) articles, of which 1 article considered dementia and 7 articles considered CCI. The study examining the risk of dementia after MTBI did not find an association. One randomized controlled trial found that being informed about possible cognitive dysfunction after MTBI was associated with worse cognitive performance on standard tests. Children with MTBI and intracranial pathology ("complicated" MTBI) performed worse than did children without intracranial pathology. Children showed higher rates of cognitive symptoms a year after MTBI than did a control group.

CONCLUSIONS

There is a lack of evidence of an increased risk of dementia after MTBI. In children, objective evidence of CCI exists only for complicated MTBI. More definitive studies are needed to inform clinical decisions, assessment of prognosis, and public health policy.

Authors+Show Affiliations

University Department of Rehabilitation Medicine, Danderyd Hospital, Karolinska Institute, Stockholm, Sweden. Electronic address: alison.godbolt@ki.se.Division of Health Care and Outcomes Research, Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.Division of Health Care and Outcomes Research, Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Morton and Gloria Shulman Movement Disorders Centre, and the Edmond J. Safra Program in Parkinson's Research, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Faculty of Health, Institute of Sport Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Department of Health Sciences, Lakehead University, Thunder Bay, Ontario, Canada; Institute for Work and Health, Toronto, Ontario, Canada; Division of Human Sciences, Northern Ontario School of Medicine, Lakehead University, Thunder Bay, Ontario, Canada.National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA.Division of Health Care and Outcomes Research, Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Faculty of Health, Institute of Sport Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

24581910

Citation

Godbolt, Alison K., et al. "Systematic Review of the Risk of Dementia and Chronic Cognitive Impairment After Mild Traumatic Brain Injury: Results of the International Collaboration On Mild Traumatic Brain Injury Prognosis." Archives of Physical Medicine and Rehabilitation, vol. 95, no. 3 Suppl, 2014, pp. S245-56.
Godbolt AK, Cancelliere C, Hincapié CA, et al. Systematic review of the risk of dementia and chronic cognitive impairment after mild traumatic brain injury: results of the International Collaboration on Mild Traumatic Brain Injury Prognosis. Arch Phys Med Rehabil. 2014;95(3 Suppl):S245-56.
Godbolt, A. K., Cancelliere, C., Hincapié, C. A., Marras, C., Boyle, E., Kristman, V. L., Coronado, V. G., & Cassidy, J. D. (2014). Systematic review of the risk of dementia and chronic cognitive impairment after mild traumatic brain injury: results of the International Collaboration on Mild Traumatic Brain Injury Prognosis. Archives of Physical Medicine and Rehabilitation, 95(3 Suppl), S245-56. https://doi.org/10.1016/j.apmr.2013.06.036
Godbolt AK, et al. Systematic Review of the Risk of Dementia and Chronic Cognitive Impairment After Mild Traumatic Brain Injury: Results of the International Collaboration On Mild Traumatic Brain Injury Prognosis. Arch Phys Med Rehabil. 2014;95(3 Suppl):S245-56. PubMed PMID: 24581910.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Systematic review of the risk of dementia and chronic cognitive impairment after mild traumatic brain injury: results of the International Collaboration on Mild Traumatic Brain Injury Prognosis. AU - Godbolt,Alison K, AU - Cancelliere,Carol, AU - Hincapié,Cesar A, AU - Marras,Connie, AU - Boyle,Eleanor, AU - Kristman,Vicki L, AU - Coronado,Victor G, AU - Cassidy,J David, PY - 2013/02/06/received PY - 2013/04/27/revised PY - 2013/06/27/accepted PY - 2014/3/4/entrez PY - 2014/3/4/pubmed PY - 2014/4/30/medline KW - Cognition disorders KW - Craniocerebral trauma KW - Dementia KW - Outcome assessment KW - Prognosis KW - Rehabilitation SP - S245 EP - 56 JF - Archives of physical medicine and rehabilitation JO - Arch Phys Med Rehabil VL - 95 IS - 3 Suppl N2 - OBJECTIVE: To synthesize the best available evidence regarding the risk of dementia and chronic cognitive impairment (CCI) after mild traumatic brain injury (MTBI). DATA SOURCES: MEDLINE and other databases were searched (2001-2012) using a previously published search strategy and predefined criteria. Peer-reviewed reports in 6 languages were considered. STUDY SELECTION: Systematic reviews, meta-analyses, randomized controlled trials, cohort studies, and case-control studies, with a minimum of 30 MTBI cases in subjects of any age, assessing the risk of dementia or CCI after MTBI were selected. DATA EXTRACTION: Eligible studies were critically appraised using a modification of the Scottish Intercollegiate Guidelines Network criteria. Two reviewers independently reviewed each study and extracted data from accepted articles (ie, with a low risk of bias) into evidence tables. DATA SYNTHESIS: Evidence from accepted studies was synthesized qualitatively according to modified Scottish Intercollegiate Guidelines Network criteria, and prognostic information was prioritized as exploratory or confirmatory according to design. Of 77,914 records screened, 299 articles were eligible and reviewed. Methodological quality was acceptable for 101 (34%) articles, of which 1 article considered dementia and 7 articles considered CCI. The study examining the risk of dementia after MTBI did not find an association. One randomized controlled trial found that being informed about possible cognitive dysfunction after MTBI was associated with worse cognitive performance on standard tests. Children with MTBI and intracranial pathology ("complicated" MTBI) performed worse than did children without intracranial pathology. Children showed higher rates of cognitive symptoms a year after MTBI than did a control group. CONCLUSIONS: There is a lack of evidence of an increased risk of dementia after MTBI. In children, objective evidence of CCI exists only for complicated MTBI. More definitive studies are needed to inform clinical decisions, assessment of prognosis, and public health policy. SN - 1532-821X UR - https://www.unboundmedicine.com/medline/citation/24581910/Systematic_review_of_the_risk_of_dementia_and_chronic_cognitive_impairment_after_mild_traumatic_brain_injury:_results_of_the_International_Collaboration_on_Mild_Traumatic_Brain_Injury_Prognosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-9993(13)01066-6 DB - PRIME DP - Unbound Medicine ER -