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Antifungal efficacy of thymol, carvacrol, eugenol and menthol as alternative agents to control the growth of food-relevant fungi.
J Mycol Med. 2014 Jun; 24(2):e51-6.JM

Abstract

OBJECTIVE

This work is an attempt to examine the antifungal activity of thymol, carvacrol, eugenol and menthol against 11 food-decaying fungi.

METHODS

The susceptibility test for the compounds was carried out in terms of minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) using microdilution method in 96 multi-well microtiter plates.

RESULTS

Results indicated that all compounds were effective to varying extents against various fungal isolates, with the highest efficacy displayed by carvacrol (mean MIC value: 154.5 μg/mL) (P<0.05). The incorporation of increased concentrations of all compounds to the media led to progressive and significant reduction in growth for all fungi. The most potent inhibitory activity of thymol, carvacrol, eugenol and menthol was found for Cladosporium spp. (MIC: 100 μg/mL), Aspergillus spp. (MIC: 100 μg/mL), Cladosporium spp. (MIC: 350 μg/mL), and Aspergillus spp. and Cladosporium spp. (MIC: 125 μg/mL), respectively.

CONCLUSION

Thus, the application of these herbal components could be considered as a good alternatives to inhibit fungal growth and to reduce the use of synthetic fungicides.

Authors+Show Affiliations

Baqiyatallah university of medical sciences, Tehran, Iran.Mycology research center, faculty of veterinary medicine, university of Tehran, Tehran, Iran.Faculty of veterinary medicine, Amol university of special modern technologies, 24th aftab, Imam Khomeini street, Amol, Iran. Electronic address: hshokri@umz.ac.ir.Mycology research center, faculty of veterinary medicine, university of Tehran, Tehran, Iran.Kermanshah university of medical sciences, Kermanshah, Iran.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24582134

Citation

Abbaszadeh, S, et al. "Antifungal Efficacy of Thymol, Carvacrol, Eugenol and Menthol as Alternative Agents to Control the Growth of Food-relevant Fungi." Journal De Mycologie Medicale, vol. 24, no. 2, 2014, pp. e51-6.
Abbaszadeh S, Sharifzadeh A, Shokri H, et al. Antifungal efficacy of thymol, carvacrol, eugenol and menthol as alternative agents to control the growth of food-relevant fungi. J Mycol Med. 2014;24(2):e51-6.
Abbaszadeh, S., Sharifzadeh, A., Shokri, H., Khosravi, A. R., & Abbaszadeh, A. (2014). Antifungal efficacy of thymol, carvacrol, eugenol and menthol as alternative agents to control the growth of food-relevant fungi. Journal De Mycologie Medicale, 24(2), e51-6. https://doi.org/10.1016/j.mycmed.2014.01.063
Abbaszadeh S, et al. Antifungal Efficacy of Thymol, Carvacrol, Eugenol and Menthol as Alternative Agents to Control the Growth of Food-relevant Fungi. J Mycol Med. 2014;24(2):e51-6. PubMed PMID: 24582134.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antifungal efficacy of thymol, carvacrol, eugenol and menthol as alternative agents to control the growth of food-relevant fungi. AU - Abbaszadeh,S, AU - Sharifzadeh,A, AU - Shokri,H, AU - Khosravi,A R, AU - Abbaszadeh,A, Y1 - 2014/02/26/ PY - 2013/03/27/received PY - 2013/11/23/revised PY - 2014/01/07/accepted PY - 2014/3/4/entrez PY - 2014/3/4/pubmed PY - 2015/4/17/medline KW - Aspergillus KW - Carvacrol KW - De champignons KW - Eugenol KW - Foodborne KW - Fungi KW - Le thymol KW - Menthol KW - Thymol KW - Toxi-infections alimentaires SP - e51 EP - 6 JF - Journal de mycologie medicale JO - J Mycol Med VL - 24 IS - 2 N2 - OBJECTIVE: This work is an attempt to examine the antifungal activity of thymol, carvacrol, eugenol and menthol against 11 food-decaying fungi. METHODS: The susceptibility test for the compounds was carried out in terms of minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) using microdilution method in 96 multi-well microtiter plates. RESULTS: Results indicated that all compounds were effective to varying extents against various fungal isolates, with the highest efficacy displayed by carvacrol (mean MIC value: 154.5 μg/mL) (P<0.05). The incorporation of increased concentrations of all compounds to the media led to progressive and significant reduction in growth for all fungi. The most potent inhibitory activity of thymol, carvacrol, eugenol and menthol was found for Cladosporium spp. (MIC: 100 μg/mL), Aspergillus spp. (MIC: 100 μg/mL), Cladosporium spp. (MIC: 350 μg/mL), and Aspergillus spp. and Cladosporium spp. (MIC: 125 μg/mL), respectively. CONCLUSION: Thus, the application of these herbal components could be considered as a good alternatives to inhibit fungal growth and to reduce the use of synthetic fungicides. SN - 1773-0449 UR - https://www.unboundmedicine.com/medline/citation/24582134/Antifungal_efficacy_of_thymol_carvacrol_eugenol_and_menthol_as_alternative_agents_to_control_the_growth_of_food_relevant_fungi_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1156-5233(14)00064-X DB - PRIME DP - Unbound Medicine ER -