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Changes in nasopharyngeal carriage of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis among healthy children attending a day-care centre before and after official financial support for the 7-valent pneumococcal conjugate vaccine and H. influenzae type b vaccine in Japan.
J Infect Chemother. 2014 Feb; 20(2):146-9.JI

Abstract

The 7-valent pneumococcal conjugate vaccine (PCV7) and Haemophilus influenzae type b (Hib) vaccine reduce nasopharyngeal carriage of vaccine-type bacteria, which may in turn influence the presence of other nasopharyngeal bacterial pathogens. To investigate this possibility, nasopharyngeal carriage of potential pathogens was examined before and after official financial support was provided to offer the PCV7 and Hib vaccines in healthy children attending a day care centre in Japan during 2011-2012. Despite a virtual disappearance of PCV7 serotypes over time, the overall pneumococcal carriage rate remained unchanged. Although others have reported an increase in PCV13 serotypes following PCV7 vaccination, only non-PCV13 serotypes were observed to have increased in this study. The majority of H. influenzae isolates were non-typeable and Hib was not found. Our data identified an unexpected pattern of pneumococcal serotype replacement following PCV7. Continuous monitoring of pneumococcal carriage is important for decisions regarding the future of national vaccination policy in Japan.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, Japan. Electronic address: oikawa@chiba-u.jp.

Division of Control and Treatment of Infectious Diseases, Chiba University Hospital, Chiba, Japan.

Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, Japan.

Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, Japan.

Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, Japan.

Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, Japan.

Division of Laboratory Medicine, Chiba University Hospital, Chiba, Japan.

Department of Bacteriology Ⅰ, National Institute of Infection Diseases, Tokyo, Japan.

Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, Japan.

MeSH

Carrier StateChildChild Day Care CentersChild, PreschoolFemaleGram-Negative Bacterial InfectionsHaemophilus VaccinesHaemophilus influenzaeHeptavalent Pneumococcal Conjugate VaccineHumansInfantJapanMaleMoraxella catarrhalisNasopharynxPneumococcal InfectionsPneumococcal VaccinesStreptococcus pneumoniae

Pub Type(s)

Journal Article

Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24582389

Citation

Oikawa, Junko, et al. "Changes in Nasopharyngeal Carriage of Streptococcus Pneumoniae, Haemophilus Influenzae and Moraxella Catarrhalis Among Healthy Children Attending a Day-care Centre Before and After Official Financial Support for the 7-valent Pneumococcal Conjugate Vaccine and H. Influenzae Type B Vaccine in Japan." Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy, vol. 20, no. 2, 2014, pp. 146-9.

Oikawa J, Ishiwada N, Takahashi Y, et al. Changes in nasopharyngeal carriage of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis among healthy children attending a day-care centre before and after official financial support for the 7-valent pneumococcal conjugate vaccine and H. influenzae type b vaccine in Japan. J Infect Chemother. 2014;20(2):146-9.

Oikawa, J., Ishiwada, N., Takahashi, Y., Hishiki, H., Nagasawa, K., Takahashi, S., Watanabe, M., Chang, B., & Kohno, Y. (2014). Changes in nasopharyngeal carriage of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis among healthy children attending a day-care centre before and after official financial support for the 7-valent pneumococcal conjugate vaccine and H. influenzae type b vaccine in Japan. Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy, 20(2), 146-9. https://doi.org/10.1016/j.jiac.2013.10.007

Oikawa J, et al. Changes in Nasopharyngeal Carriage of Streptococcus Pneumoniae, Haemophilus Influenzae and Moraxella Catarrhalis Among Healthy Children Attending a Day-care Centre Before and After Official Financial Support for the 7-valent Pneumococcal Conjugate Vaccine and H. Influenzae Type B Vaccine in Japan. J Infect Chemother. 2014;20(2):146-9. PubMed PMID: 24582389.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Changes in nasopharyngeal carriage of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis among healthy children attending a day-care centre before and after official financial support for the 7-valent pneumococcal conjugate vaccine and H. influenzae type b vaccine in Japan. AU - Oikawa,Junko, AU - Ishiwada,Naruhiko, AU - Takahashi,Yoshiko, AU - Hishiki,Haruka, AU - Nagasawa,Koo, AU - Takahashi,Sachiko, AU - Watanabe,Masaharu, AU - Chang,Bin, AU - Kohno,Yoichi, Y1 - 2013/12/11/ PY - 2013/08/07/received PY - 2013/10/16/revised PY - 2013/10/19/accepted PY - 2014/3/4/entrez PY - 2014/3/4/pubmed PY - 2014/11/18/medline KW - 7-Valent pneumococcal conjugate vaccine KW - Haemophilus influenzae KW - Hib vaccine KW - Nasopharyngeal carriage KW - Streptococcus pneumoniae SP - 146 EP - 9 JF - Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy JO - J Infect Chemother VL - 20 IS - 2 N2 - The 7-valent pneumococcal conjugate vaccine (PCV7) and Haemophilus influenzae type b (Hib) vaccine reduce nasopharyngeal carriage of vaccine-type bacteria, which may in turn influence the presence of other nasopharyngeal bacterial pathogens. To investigate this possibility, nasopharyngeal carriage of potential pathogens was examined before and after official financial support was provided to offer the PCV7 and Hib vaccines in healthy children attending a day care centre in Japan during 2011-2012. Despite a virtual disappearance of PCV7 serotypes over time, the overall pneumococcal carriage rate remained unchanged. Although others have reported an increase in PCV13 serotypes following PCV7 vaccination, only non-PCV13 serotypes were observed to have increased in this study. The majority of H. influenzae isolates were non-typeable and Hib was not found. Our data identified an unexpected pattern of pneumococcal serotype replacement following PCV7. Continuous monitoring of pneumococcal carriage is important for decisions regarding the future of national vaccination policy in Japan. SN - 1437-7780 UR - https://www.unboundmedicine.com/medline/citation/24582389/Changes_in_nasopharyngeal_carriage_of_Streptococcus_pneumoniae_Haemophilus_influenzae_and_Moraxella_catarrhalis_among_healthy_children_attending_a_day_care_centre_before_and_after_official_financial_support_for_the_7_valent_pneumococcal_conjugate_vaccine_and_H__influenzae_type_b_vaccine_in_Japan_ DB - PRIME DP - Unbound Medicine ER -