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Inhibitory effects of steroidal anesthetics on histamine release from rat mast cells stimulated by concanavalin A, compound 48/80 and A23187.
Gen Pharmacol. 1988; 19(3):435-40.GP

Abstract

1. Alphaxalone and alphadolone acetate were found to inhibit histamine release from rat mast cells induced by concanavalin A by blocking the calcium channels of the cells. 2. They also both inhibited the release induced by A23187, but only alphaxalone inhibited the release induced by compound 48/80. 3. It is concluded that the inhibitory effects of these compounds were not due to their anesthetic properties, but may have been due to their inhibition of steps of the release cascade that open calcium channels and subsequent steps.

Authors+Show Affiliations

Suzuki T
Department of Molecular Pharmacology, Meiji College of Pharmacy, Tokyo, Japan.
Tomioka M
No affiliation info available
Uchida MK
No affiliation info available

MeSH

AnestheticsAnimalsCalcimycinCalciumConcanavalin ADrug InteractionsHistamine ReleaseIn Vitro TechniquesMaleMast CellsPregnanedionesRatsRats, Inbred StrainsReceptors, Concanavalin Ap-Methoxy-N-methylphenethylamine

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2458297

Citation

Suzuki, T, et al. "Inhibitory Effects of Steroidal Anesthetics On Histamine Release From Rat Mast Cells Stimulated By Concanavalin A, Compound 48/80 and A23187." General Pharmacology, vol. 19, no. 3, 1988, pp. 435-40.
Suzuki T, Tomioka M, Uchida MK. Inhibitory effects of steroidal anesthetics on histamine release from rat mast cells stimulated by concanavalin A, compound 48/80 and A23187. Gen Pharmacol. 1988;19(3):435-40.
Suzuki, T., Tomioka, M., & Uchida, M. K. (1988). Inhibitory effects of steroidal anesthetics on histamine release from rat mast cells stimulated by concanavalin A, compound 48/80 and A23187. General Pharmacology, 19(3), 435-40.
Suzuki T, Tomioka M, Uchida MK. Inhibitory Effects of Steroidal Anesthetics On Histamine Release From Rat Mast Cells Stimulated By Concanavalin A, Compound 48/80 and A23187. Gen Pharmacol. 1988;19(3):435-40. PubMed PMID: 2458297.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitory effects of steroidal anesthetics on histamine release from rat mast cells stimulated by concanavalin A, compound 48/80 and A23187. AU - Suzuki,T, AU - Tomioka,M, AU - Uchida,M K, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 435 EP - 40 JF - General pharmacology JO - Gen Pharmacol VL - 19 IS - 3 N2 - 1. Alphaxalone and alphadolone acetate were found to inhibit histamine release from rat mast cells induced by concanavalin A by blocking the calcium channels of the cells. 2. They also both inhibited the release induced by A23187, but only alphaxalone inhibited the release induced by compound 48/80. 3. It is concluded that the inhibitory effects of these compounds were not due to their anesthetic properties, but may have been due to their inhibition of steps of the release cascade that open calcium channels and subsequent steps. SN - 0306-3623 UR - https://www.unboundmedicine.com/medline/citation/2458297/Inhibitory_effects_of_steroidal_anesthetics_on_histamine_release_from_rat_mast_cells_stimulated_by_concanavalin_A_compound_48/80_and_A23187_ DB - PRIME DP - Unbound Medicine ER -