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Alteration of the intestinal microbiota as a cause of and a potential therapeutic option in irritable bowel syndrome.
Benef Microbes. 2014 Sep; 5(3):247-61.BM

Abstract

The intestinal microbiota forms a complex ecosystem that is in close contact with its host and has an important impact on health. An increasing number of disorders are associated with disturbances in this ecosystem. Also patients suffering from irritable bowel syndrome (IBS) show an altered composition of their gut microbiota. IBS is a multifactorial chronic disorder characterised by various abdominal complaints and a worldwide prevalence of 10-20%. Even though its aetiology and pathophysiology are complex and not well understood, it is widely accepted that aberrations along the microbe-gut-brain axis are involved. In this review, it will be discussed how exogenous factors, e.g. antibiotics, can cause disbalance in the intestinal microbiota and thereby contribute to the development of IBS. In addition, several new IBS treatment options that aim at re-establishing a healthy, beneficial ecosystem will be described. These include antibiotics, probiotics, prebiotics and faecal transplantation.

Authors+Show Affiliations

School of Health and Medical Sciences, Faculty of Medicine and Health, Örebro University, 701 82 Örebro, Sweden.School of Health and Medical Sciences, Faculty of Medicine and Health, Örebro University, 701 82 Örebro, Sweden.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24583610

Citation

König, J, and R J. Brummer. "Alteration of the Intestinal Microbiota as a Cause of and a Potential Therapeutic Option in Irritable Bowel Syndrome." Beneficial Microbes, vol. 5, no. 3, 2014, pp. 247-61.
König J, Brummer RJ. Alteration of the intestinal microbiota as a cause of and a potential therapeutic option in irritable bowel syndrome. Benef Microbes. 2014;5(3):247-61.
König, J., & Brummer, R. J. (2014). Alteration of the intestinal microbiota as a cause of and a potential therapeutic option in irritable bowel syndrome. Beneficial Microbes, 5(3), 247-61. https://doi.org/10.3920/BM2013.0033
König J, Brummer RJ. Alteration of the Intestinal Microbiota as a Cause of and a Potential Therapeutic Option in Irritable Bowel Syndrome. Benef Microbes. 2014;5(3):247-61. PubMed PMID: 24583610.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alteration of the intestinal microbiota as a cause of and a potential therapeutic option in irritable bowel syndrome. AU - König,J, AU - Brummer,R J, PY - 2014/3/4/entrez PY - 2014/3/4/pubmed PY - 2015/4/17/medline KW - antibiotics KW - faecal transplantation KW - gut microbiota KW - prebiotics KW - probiotics SP - 247 EP - 61 JF - Beneficial microbes JO - Benef Microbes VL - 5 IS - 3 N2 - The intestinal microbiota forms a complex ecosystem that is in close contact with its host and has an important impact on health. An increasing number of disorders are associated with disturbances in this ecosystem. Also patients suffering from irritable bowel syndrome (IBS) show an altered composition of their gut microbiota. IBS is a multifactorial chronic disorder characterised by various abdominal complaints and a worldwide prevalence of 10-20%. Even though its aetiology and pathophysiology are complex and not well understood, it is widely accepted that aberrations along the microbe-gut-brain axis are involved. In this review, it will be discussed how exogenous factors, e.g. antibiotics, can cause disbalance in the intestinal microbiota and thereby contribute to the development of IBS. In addition, several new IBS treatment options that aim at re-establishing a healthy, beneficial ecosystem will be described. These include antibiotics, probiotics, prebiotics and faecal transplantation. SN - 1876-2891 UR - https://www.unboundmedicine.com/medline/citation/24583610/Alteration_of_the_intestinal_microbiota_as_a_cause_of_and_a_potential_therapeutic_option_in_irritable_bowel_syndrome_ L2 - https://www.wageningenacademic.com/doi/10.3920/BM2013.0033?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -