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Modulation of hepatic steatosis by dietary fatty acids.
World J Gastroenterol 2014; 20(7):1746-55WJ

Abstract

Non-alcoholic fatty liver disease (NAFLD) describes a range of conditions caused by fat deposition within liver cells. Liver fat content reflects the equilibrium between several metabolic pathways involved in triglyceride synthesis and disposal, such as lipolysis in adipose tissue and de novo lipogenesis, triglyceride esterification, fatty acid oxidation and very-low-density lipoprotein synthesis/secretion in hepatic tissue. In particular, it has been demonstrated that hepatic de novo lipogenesis plays a significant role in NAFLD pathogenesis. It is widely known that the fatty acid composition of the diet influences hepatic lipogenesis along with other metabolic pathways. Therefore, dietary fat may not only be involved in the pathogenesis of hepatic steatosis, but may also prevent and/or reverse hepatic fat accumulation. In this review, major data from the literature about the role of some dietary fats as a potential cause of hepatic fat accumulation or as a potential treatment for NAFLD are described. Moreover, biochemical mechanisms responsible for an increase or decrease in hepatic lipid content are critically analyzed. It is noteworthy that both quantitative and qualitative aspects of dietary fat influence triglyceride deposition in the liver. A high-fat diet or the dietary administration of conjugated linoleic acids induced hepatic steatosis. In contrast, supplementation of the diet with krill oil or pine nut oil helped in the prevention and/or in the treatment of steatotic liver. Quite interesting is the "case" of olive oil, since several studies have often provided different and/or conflicting results in animal models.

Authors+Show Affiliations

Alessandra Ferramosca, Vincenzo Zara, Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, I-73100 Lecce, Italy.Alessandra Ferramosca, Vincenzo Zara, Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, I-73100 Lecce, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24587652

Citation

Ferramosca, Alessandra, and Vincenzo Zara. "Modulation of Hepatic Steatosis By Dietary Fatty Acids." World Journal of Gastroenterology, vol. 20, no. 7, 2014, pp. 1746-55.
Ferramosca A, Zara V. Modulation of hepatic steatosis by dietary fatty acids. World J Gastroenterol. 2014;20(7):1746-55.
Ferramosca, A., & Zara, V. (2014). Modulation of hepatic steatosis by dietary fatty acids. World Journal of Gastroenterology, 20(7), pp. 1746-55. doi:10.3748/wjg.v20.i7.1746.
Ferramosca A, Zara V. Modulation of Hepatic Steatosis By Dietary Fatty Acids. World J Gastroenterol. 2014 Feb 21;20(7):1746-55. PubMed PMID: 24587652.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulation of hepatic steatosis by dietary fatty acids. AU - Ferramosca,Alessandra, AU - Zara,Vincenzo, PY - 2013/09/13/received PY - 2013/10/13/revised PY - 2013/11/03/accepted PY - 2014/3/4/entrez PY - 2014/3/4/pubmed PY - 2015/4/9/medline KW - Fatty acids KW - Hepatic steatosis KW - Lipogenesis KW - Non-alcoholic fatty liver SP - 1746 EP - 55 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 20 IS - 7 N2 - Non-alcoholic fatty liver disease (NAFLD) describes a range of conditions caused by fat deposition within liver cells. Liver fat content reflects the equilibrium between several metabolic pathways involved in triglyceride synthesis and disposal, such as lipolysis in adipose tissue and de novo lipogenesis, triglyceride esterification, fatty acid oxidation and very-low-density lipoprotein synthesis/secretion in hepatic tissue. In particular, it has been demonstrated that hepatic de novo lipogenesis plays a significant role in NAFLD pathogenesis. It is widely known that the fatty acid composition of the diet influences hepatic lipogenesis along with other metabolic pathways. Therefore, dietary fat may not only be involved in the pathogenesis of hepatic steatosis, but may also prevent and/or reverse hepatic fat accumulation. In this review, major data from the literature about the role of some dietary fats as a potential cause of hepatic fat accumulation or as a potential treatment for NAFLD are described. Moreover, biochemical mechanisms responsible for an increase or decrease in hepatic lipid content are critically analyzed. It is noteworthy that both quantitative and qualitative aspects of dietary fat influence triglyceride deposition in the liver. A high-fat diet or the dietary administration of conjugated linoleic acids induced hepatic steatosis. In contrast, supplementation of the diet with krill oil or pine nut oil helped in the prevention and/or in the treatment of steatotic liver. Quite interesting is the "case" of olive oil, since several studies have often provided different and/or conflicting results in animal models. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/24587652/Modulation_of_hepatic_steatosis_by_dietary_fatty_acids_ L2 - http://www.wjgnet.com/1007-9327/full/v20/i7/1746.htm DB - PRIME DP - Unbound Medicine ER -