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Fatty acids found in dairy, protein and unsaturated fatty acids are associated with risk of pancreatic cancer in a case-control study.

Abstract

Although many studies have investigated meat and total fat in relation to pancreatic cancer risk, few have investigated dairy, fish and specific fatty acids (FAs). We evaluated the association between intake of meat, fish, dairy, specific FAs and related nutrients and pancreatic cancer. In our American-based Mayo Clinic case-control study 384 cases and 983 controls frequency matched on recruitment age, race, sex and residence area (Minnesota, Wisconsin or Iowa, USA) between 2004 and 2009. All subjects provided demographic information and completed 144-item food frequency questionnaire. Logistic regression-calculated odds ratios (ORs) and 95% confidence intervals (95% CIs) were adjusted for age, sex, cigarette smoking, body mass index and diabetes mellitus. Significant inverse association (trend p-value < 0.05) between pancreatic cancer and the groupings (highest vs. lowest consumption quintile OR [95% CI]) was as follows: meat replacement (0.67 [0.43-1.02]), total protein (0.58 [0.39-0.86]), vitamin B12 (0.67 [0.44, 1.01]), zinc (0.48 [0.32, 0.71]), phosphorus (0.62 [0.41, 0.93]), vitamin E (0.51 [0.33, 0.78]), polyunsaturated FAs (0.64 [0.42, 0.98]) and linoleic acid (FA 18:2) (0.62 [0.40-0.95]). Increased risk associations were observed for saturated FAs (1.48 [0.97-2.23]), butyric acid (FA 4:0) (1.77 [1.19-2.64]), caproic acid (FA 6:0) (2.15 [1.42-3.27]), caprylic acid (FA 8:0) (1.87 [1.27-2.76]) and capric acid (FA 10:0) (1.83 [1.23-2.74]). Our study suggests that eating a diet high in total protein and certain unsaturated FAs is associated with decreased risk of developing pancreatic cancer in a dose-dependent manner, whereas fats found in dairy increase risk.

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  • Authors+Show Affiliations

    ,

    Division of Epidemiology Department of Health Sciences Research, Mayo Clinic, Rochester, MN.

    , , , , , , , , ,

    Source

    International journal of cancer 134:8 2014 Apr 15 pg 1935-46

    MeSH

    Aged
    Case-Control Studies
    Dairy Products
    Diet
    Dietary Fats
    Fatty Acids, Unsaturated
    Feeding Behavior
    Female
    Humans
    Male
    Meat
    Pancreatic Neoplasms
    Proteins
    Risk Factors
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    24590454

    Citation

    Jansen, Rick J., et al. "Fatty Acids Found in Dairy, Protein and Unsaturated Fatty Acids Are Associated With Risk of Pancreatic Cancer in a Case-control Study." International Journal of Cancer, vol. 134, no. 8, 2014, pp. 1935-46.
    Jansen RJ, Robinson DP, Frank RD, et al. Fatty acids found in dairy, protein and unsaturated fatty acids are associated with risk of pancreatic cancer in a case-control study. Int J Cancer. 2014;134(8):1935-46.
    Jansen, R. J., Robinson, D. P., Frank, R. D., Anderson, K. E., Bamlet, W. R., Oberg, A. L., ... Stolzenberg-Solomon, R. Z. (2014). Fatty acids found in dairy, protein and unsaturated fatty acids are associated with risk of pancreatic cancer in a case-control study. International Journal of Cancer, 134(8), pp. 1935-46. doi:10.1002/ijc.28525.
    Jansen RJ, et al. Fatty Acids Found in Dairy, Protein and Unsaturated Fatty Acids Are Associated With Risk of Pancreatic Cancer in a Case-control Study. Int J Cancer. 2014 Apr 15;134(8):1935-46. PubMed PMID: 24590454.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Fatty acids found in dairy, protein and unsaturated fatty acids are associated with risk of pancreatic cancer in a case-control study. AU - Jansen,Rick J, AU - Robinson,Dennis P, AU - Frank,Ryan D, AU - Anderson,Kristin E, AU - Bamlet,William R, AU - Oberg,Ann L, AU - Rabe,Kari G, AU - Olson,Janet E, AU - Sinha,Rashmi, AU - Petersen,Gloria M, AU - Stolzenberg-Solomon,Rachael Z, Y1 - 2013/10/29/ PY - 2013/04/18/received PY - 2013/09/20/accepted PY - 2014/3/5/entrez PY - 2014/3/5/pubmed PY - 2014/5/16/medline KW - case-control study KW - dairy consumption KW - fat consumption KW - meat consumption KW - pancreatic cancer SP - 1935 EP - 46 JF - International journal of cancer JO - Int. J. Cancer VL - 134 IS - 8 N2 - Although many studies have investigated meat and total fat in relation to pancreatic cancer risk, few have investigated dairy, fish and specific fatty acids (FAs). We evaluated the association between intake of meat, fish, dairy, specific FAs and related nutrients and pancreatic cancer. In our American-based Mayo Clinic case-control study 384 cases and 983 controls frequency matched on recruitment age, race, sex and residence area (Minnesota, Wisconsin or Iowa, USA) between 2004 and 2009. All subjects provided demographic information and completed 144-item food frequency questionnaire. Logistic regression-calculated odds ratios (ORs) and 95% confidence intervals (95% CIs) were adjusted for age, sex, cigarette smoking, body mass index and diabetes mellitus. Significant inverse association (trend p-value < 0.05) between pancreatic cancer and the groupings (highest vs. lowest consumption quintile OR [95% CI]) was as follows: meat replacement (0.67 [0.43-1.02]), total protein (0.58 [0.39-0.86]), vitamin B12 (0.67 [0.44, 1.01]), zinc (0.48 [0.32, 0.71]), phosphorus (0.62 [0.41, 0.93]), vitamin E (0.51 [0.33, 0.78]), polyunsaturated FAs (0.64 [0.42, 0.98]) and linoleic acid (FA 18:2) (0.62 [0.40-0.95]). Increased risk associations were observed for saturated FAs (1.48 [0.97-2.23]), butyric acid (FA 4:0) (1.77 [1.19-2.64]), caproic acid (FA 6:0) (2.15 [1.42-3.27]), caprylic acid (FA 8:0) (1.87 [1.27-2.76]) and capric acid (FA 10:0) (1.83 [1.23-2.74]). Our study suggests that eating a diet high in total protein and certain unsaturated FAs is associated with decreased risk of developing pancreatic cancer in a dose-dependent manner, whereas fats found in dairy increase risk. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/24590454/Fatty_acids_found_in_dairy_protein_and_unsaturated_fatty_acids_are_associated_with_risk_of_pancreatic_cancer_in_a_case_control_study_ L2 - https://doi.org/10.1002/ijc.28525 DB - PRIME DP - Unbound Medicine ER -