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Cochlear blood flow increases after systemic hemodilution: comparison of simultaneous laser Doppler flowmetry and radioactive microsphere measurements.
Hear Res. 1988 Aug; 34(3):215-23.HR

Abstract

Guinea pig cochlear blood flow was measured before and after systemic normovolemic hemodilution with high molecular weight dextran. Absolute determinations of blood flow (in the cochlea, brain, kidney and lung) were accomplished by use of radioactive-labeled (85Sr or 141Ce) microspheres. Relative measurements of the cochlear blood flow changes were made simultaneously by the use of a laser Doppler flowmeter. The flowmeter probe was placed on the first cochlear turn. Hemodilution to an average systemic hematocrit of 20% increased cochlear blood flow by 250% as measured with microspheres. The laser Doppler instrument significantly underestimated the actual flow increase giving an indication of 148%. Furthermore, the data, when analyzed on an individual trial basis, showed a very poor correlation between the two methods. The theoretical basis for these findings in relation to the use of the laser Doppler instrument is discussed.

Authors+Show Affiliations

Kresge Hearing Research Institute, Department of Otolaryngology - Head and Neck Surgery, Medical School, University of Michigan, Ann Arbor 48109-0506.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2459097

Citation

Nuttall, A L., et al. "Cochlear Blood Flow Increases After Systemic Hemodilution: Comparison of Simultaneous Laser Doppler Flowmetry and Radioactive Microsphere Measurements." Hearing Research, vol. 34, no. 3, 1988, pp. 215-23.
Nuttall AL, Hultcrantz E, Larsen HC, et al. Cochlear blood flow increases after systemic hemodilution: comparison of simultaneous laser Doppler flowmetry and radioactive microsphere measurements. Hear Res. 1988;34(3):215-23.
Nuttall, A. L., Hultcrantz, E., Larsen, H. C., & Angelborg, C. (1988). Cochlear blood flow increases after systemic hemodilution: comparison of simultaneous laser Doppler flowmetry and radioactive microsphere measurements. Hearing Research, 34(3), 215-23.
Nuttall AL, et al. Cochlear Blood Flow Increases After Systemic Hemodilution: Comparison of Simultaneous Laser Doppler Flowmetry and Radioactive Microsphere Measurements. Hear Res. 1988;34(3):215-23. PubMed PMID: 2459097.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cochlear blood flow increases after systemic hemodilution: comparison of simultaneous laser Doppler flowmetry and radioactive microsphere measurements. AU - Nuttall,A L, AU - Hultcrantz,E, AU - Larsen,H C, AU - Angelborg,C, PY - 1988/8/1/pubmed PY - 1988/8/1/medline PY - 1988/8/1/entrez SP - 215 EP - 23 JF - Hearing research JO - Hear. Res. VL - 34 IS - 3 N2 - Guinea pig cochlear blood flow was measured before and after systemic normovolemic hemodilution with high molecular weight dextran. Absolute determinations of blood flow (in the cochlea, brain, kidney and lung) were accomplished by use of radioactive-labeled (85Sr or 141Ce) microspheres. Relative measurements of the cochlear blood flow changes were made simultaneously by the use of a laser Doppler flowmeter. The flowmeter probe was placed on the first cochlear turn. Hemodilution to an average systemic hematocrit of 20% increased cochlear blood flow by 250% as measured with microspheres. The laser Doppler instrument significantly underestimated the actual flow increase giving an indication of 148%. Furthermore, the data, when analyzed on an individual trial basis, showed a very poor correlation between the two methods. The theoretical basis for these findings in relation to the use of the laser Doppler instrument is discussed. SN - 0378-5955 UR - https://www.unboundmedicine.com/medline/citation/2459097/Cochlear_blood_flow_increases_after_systemic_hemodilution:_comparison_of_simultaneous_laser_Doppler_flowmetry_and_radioactive_microsphere_measurements_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0378-5955(88)90001-9 DB - PRIME DP - Unbound Medicine ER -