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Delayed onset of suspected malignant hyperthermia during sevoflurane anesthesia in an Afghan trauma patient: a case report.
AANA J. 2013 Dec; 81(6):441-5.AJ

Abstract

Malignant hyperthermia (MH) is a rare pathologic hypermetabolic pharmacogenetic disorder of skeletal muscle calcium regulation following exposure to depolarizing muscle relaxants and/or volatile anesthetics. Although its pathogenesis is relatively well understood, there is wide variability in both the time of onset and the presentation of clinical signs and symptoms. In some circumstances the delayed onset of the hypermetabolic state may hinder timely recognition and treatment. Differential diagnosis of an MH crisis can be particularly challenging in a trauma patient, especially in an austere environment. This case report describes the presentation and management of a suspected case of MH in an Afghan national who underwent surgery following lower extremity trauma resulting from an improvised explosive device.

Authors+Show Affiliations

Naval Medical Center San Diego, CA, USA. rafal.banek@med.navy.milNaval Hospital Jacksonville, Florida, USA.NAVMEDWEST Region, Naval Medical San Diego, CA, USA.Uniformed Services University of the Health Sciences, Bethesda, MD, USA.Malignant Hyperthermia Testing Center, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.School of Medicine, Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

24597005

Citation

Banek, Rafal, et al. "Delayed Onset of Suspected Malignant Hyperthermia During Sevoflurane Anesthesia in an Afghan Trauma Patient: a Case Report." AANA Journal, vol. 81, no. 6, 2013, pp. 441-5.
Banek R, Weatherwax J, Spence D, et al. Delayed onset of suspected malignant hyperthermia during sevoflurane anesthesia in an Afghan trauma patient: a case report. AANA J. 2013;81(6):441-5.
Banek, R., Weatherwax, J., Spence, D., Perry, S., Muldoon, S., & Capacchione, J. (2013). Delayed onset of suspected malignant hyperthermia during sevoflurane anesthesia in an Afghan trauma patient: a case report. AANA Journal, 81(6), 441-5.
Banek R, et al. Delayed Onset of Suspected Malignant Hyperthermia During Sevoflurane Anesthesia in an Afghan Trauma Patient: a Case Report. AANA J. 2013;81(6):441-5. PubMed PMID: 24597005.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Delayed onset of suspected malignant hyperthermia during sevoflurane anesthesia in an Afghan trauma patient: a case report. AU - Banek,Rafal, AU - Weatherwax,John, AU - Spence,Dennis, AU - Perry,Susan, AU - Muldoon,Sheila, AU - Capacchione,John, PY - 2014/3/7/entrez PY - 2014/3/7/pubmed PY - 2014/4/9/medline SP - 441 EP - 5 JF - AANA journal JO - AANA J VL - 81 IS - 6 N2 - Malignant hyperthermia (MH) is a rare pathologic hypermetabolic pharmacogenetic disorder of skeletal muscle calcium regulation following exposure to depolarizing muscle relaxants and/or volatile anesthetics. Although its pathogenesis is relatively well understood, there is wide variability in both the time of onset and the presentation of clinical signs and symptoms. In some circumstances the delayed onset of the hypermetabolic state may hinder timely recognition and treatment. Differential diagnosis of an MH crisis can be particularly challenging in a trauma patient, especially in an austere environment. This case report describes the presentation and management of a suspected case of MH in an Afghan national who underwent surgery following lower extremity trauma resulting from an improvised explosive device. SN - 0094-6354 UR - https://www.unboundmedicine.com/medline/citation/24597005/Delayed_onset_of_suspected_malignant_hyperthermia_during_sevoflurane_anesthesia_in_an_Afghan_trauma_patient:_a_case_report_ L2 - http://www.diseaseinfosearch.org/result/4424 DB - PRIME DP - Unbound Medicine ER -