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Prospective study of dietary fat and risk of uterine leiomyomata.
Am J Clin Nutr 2014; 99(5):1105-16AJ

Abstract

BACKGROUND

Uterine leiomyomata (UL) are the primary indication for hysterectomy and are 2-3 times more common in black than white women. High dietary fat intake has been associated with increased endogenous concentrations of estradiol, a sex steroid hormone that is known to influence UL risk.

OBJECTIVE

We assessed the relation of dietary fat intake (total, subtypes, and selected food sources) with UL incidence.

DESIGN

Data were from the Black Women's Health Study, a prospective cohort study. Over an 8-y period (2001-2009), 12,044 premenopausal women were followed for a first diagnosis of UL. Diet was assessed via a food-frequency questionnaire in 2001. Cox regression models were used to compute incidence rate ratios (IRRs) and 95% CIs with adjustment for potential confounders.

RESULTS

During 75,687 person-years of follow-up, there were 2695 incident UL cases diagnosed by ultrasound (n = 2191) or surgery (n = 504). Intakes of total fat and fat subtypes were not appreciably associated with UL risk overall, although statistically significant associations were observed for specific saturated (inverse) and monounsaturated and polyunsaturated (positive) fatty acids. With respect to polyunsaturated fats, the IRR for the highest compared with lowest quintiles of marine fatty acid intake [the sum of omega-3 (n-3) polyunsaturated fatty acids eicosapentanoic acid, docosapentaenoic acid, and docosahexaenoic acid] was 1.18 (95% CI: 1.05, 1.34; P-trend = 0.005). The IRR for the highest compared with lowest categories of dark-meat fish consumption was 1.13 (95% CI: 1.00, 1.28).

CONCLUSIONS

In US black women, the most consistent associations of fat intake with UL were small increases in risk associated with intakes of long-chain omega-3 fatty acids. Future studies are warranted to confirm these findings and elucidate which components of fatty foods, if any, are related to UL risk.

Authors+Show Affiliations

Slone Epidemiology Center at Boston University, Boston, MA (LAW, RGR, EAR-N, JRP, and LR), and the Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA (SKK).No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

24598152

Citation

Wise, Lauren A., et al. "Prospective Study of Dietary Fat and Risk of Uterine Leiomyomata." The American Journal of Clinical Nutrition, vol. 99, no. 5, 2014, pp. 1105-16.
Wise LA, Radin RG, Kumanyika SK, et al. Prospective study of dietary fat and risk of uterine leiomyomata. Am J Clin Nutr. 2014;99(5):1105-16.
Wise, L. A., Radin, R. G., Kumanyika, S. K., Ruiz-Narváez, E. A., Palmer, J. R., & Rosenberg, L. (2014). Prospective study of dietary fat and risk of uterine leiomyomata. The American Journal of Clinical Nutrition, 99(5), pp. 1105-16. doi:10.3945/ajcn.113.073635.
Wise LA, et al. Prospective Study of Dietary Fat and Risk of Uterine Leiomyomata. Am J Clin Nutr. 2014;99(5):1105-16. PubMed PMID: 24598152.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective study of dietary fat and risk of uterine leiomyomata. AU - Wise,Lauren A, AU - Radin,Rose G, AU - Kumanyika,Shiriki K, AU - Ruiz-Narváez,Edward A, AU - Palmer,Julie R, AU - Rosenberg,Lynn, Y1 - 2014/03/05/ PY - 2014/3/7/entrez PY - 2014/3/7/pubmed PY - 2014/6/11/medline SP - 1105 EP - 16 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 99 IS - 5 N2 - BACKGROUND: Uterine leiomyomata (UL) are the primary indication for hysterectomy and are 2-3 times more common in black than white women. High dietary fat intake has been associated with increased endogenous concentrations of estradiol, a sex steroid hormone that is known to influence UL risk. OBJECTIVE: We assessed the relation of dietary fat intake (total, subtypes, and selected food sources) with UL incidence. DESIGN: Data were from the Black Women's Health Study, a prospective cohort study. Over an 8-y period (2001-2009), 12,044 premenopausal women were followed for a first diagnosis of UL. Diet was assessed via a food-frequency questionnaire in 2001. Cox regression models were used to compute incidence rate ratios (IRRs) and 95% CIs with adjustment for potential confounders. RESULTS: During 75,687 person-years of follow-up, there were 2695 incident UL cases diagnosed by ultrasound (n = 2191) or surgery (n = 504). Intakes of total fat and fat subtypes were not appreciably associated with UL risk overall, although statistically significant associations were observed for specific saturated (inverse) and monounsaturated and polyunsaturated (positive) fatty acids. With respect to polyunsaturated fats, the IRR for the highest compared with lowest quintiles of marine fatty acid intake [the sum of omega-3 (n-3) polyunsaturated fatty acids eicosapentanoic acid, docosapentaenoic acid, and docosahexaenoic acid] was 1.18 (95% CI: 1.05, 1.34; P-trend = 0.005). The IRR for the highest compared with lowest categories of dark-meat fish consumption was 1.13 (95% CI: 1.00, 1.28). CONCLUSIONS: In US black women, the most consistent associations of fat intake with UL were small increases in risk associated with intakes of long-chain omega-3 fatty acids. Future studies are warranted to confirm these findings and elucidate which components of fatty foods, if any, are related to UL risk. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/24598152/Prospective_study_of_dietary_fat_and_risk_of_uterine_leiomyomata_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.113.073635 DB - PRIME DP - Unbound Medicine ER -