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The water barrier function of the skin in relation to the water content of stratum corneum, pH and skin lipids. The effect of alkaline soap and syndet on dry skin in elderly, non-atopic patients.
Acta Derm Venereol. 1988; 68(4):277-83.AD

Abstract

Clinical dryness of the skin is a common problem among elderly, dermatological patients. In the present investigation, hydration, surface lipids, skin pH and water barrier function as expressed by the transepidermal water loss (TEWL) were studied in both dry and normal skin. Using these parameters, a comparison of the local effects of acid and alkaline cleansing products was made. In non-atopic elderly patients with dry skin, the TEWL values were lower than in the younger control group but higher than in the older controls. Following one week's topical therapy, the TEWL values in the patient group decreased further and approached the lower values of the older control group. At the same time the skin hydration values increased, indicating a beneficial effect on the skin barrier. An inverse relationship was demonstrated between TEWL and skin hydration. The study indicates that high TEWL values are frequently correlated with high pH, low hydration of the stratum corneum and reduced skin surface lipid content. Despite the intensive use of an acid syndet and lotion, the pH-readings increased but were still within the 'confidence limits' of the control groups.

Authors+Show Affiliations

Department of Dermatology, Ullevål Hospital, University of Oslo, Norway.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2459871

Citation

Thune, P, et al. "The Water Barrier Function of the Skin in Relation to the Water Content of Stratum Corneum, pH and Skin Lipids. the Effect of Alkaline Soap and Syndet On Dry Skin in Elderly, Non-atopic Patients." Acta Dermato-venereologica, vol. 68, no. 4, 1988, pp. 277-83.
Thune P, Nilsen T, Hanstad IK, et al. The water barrier function of the skin in relation to the water content of stratum corneum, pH and skin lipids. The effect of alkaline soap and syndet on dry skin in elderly, non-atopic patients. Acta Derm Venereol. 1988;68(4):277-83.
Thune, P., Nilsen, T., Hanstad, I. K., Gustavsen, T., & Lövig Dahl, H. (1988). The water barrier function of the skin in relation to the water content of stratum corneum, pH and skin lipids. The effect of alkaline soap and syndet on dry skin in elderly, non-atopic patients. Acta Dermato-venereologica, 68(4), 277-83.
Thune P, et al. The Water Barrier Function of the Skin in Relation to the Water Content of Stratum Corneum, pH and Skin Lipids. the Effect of Alkaline Soap and Syndet On Dry Skin in Elderly, Non-atopic Patients. Acta Derm Venereol. 1988;68(4):277-83. PubMed PMID: 2459871.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The water barrier function of the skin in relation to the water content of stratum corneum, pH and skin lipids. The effect of alkaline soap and syndet on dry skin in elderly, non-atopic patients. AU - Thune,P, AU - Nilsen,T, AU - Hanstad,I K, AU - Gustavsen,T, AU - Lövig Dahl,H, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 277 EP - 83 JF - Acta dermato-venereologica JO - Acta Derm Venereol VL - 68 IS - 4 N2 - Clinical dryness of the skin is a common problem among elderly, dermatological patients. In the present investigation, hydration, surface lipids, skin pH and water barrier function as expressed by the transepidermal water loss (TEWL) were studied in both dry and normal skin. Using these parameters, a comparison of the local effects of acid and alkaline cleansing products was made. In non-atopic elderly patients with dry skin, the TEWL values were lower than in the younger control group but higher than in the older controls. Following one week's topical therapy, the TEWL values in the patient group decreased further and approached the lower values of the older control group. At the same time the skin hydration values increased, indicating a beneficial effect on the skin barrier. An inverse relationship was demonstrated between TEWL and skin hydration. The study indicates that high TEWL values are frequently correlated with high pH, low hydration of the stratum corneum and reduced skin surface lipid content. Despite the intensive use of an acid syndet and lotion, the pH-readings increased but were still within the 'confidence limits' of the control groups. SN - 0001-5555 UR - https://www.unboundmedicine.com/medline/citation/2459871/The_water_barrier_function_of_the_skin_in_relation_to_the_water_content_of_stratum_corneum_pH_and_skin_lipids__The_effect_of_alkaline_soap_and_syndet_on_dry_skin_in_elderly_non_atopic_patients_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:2459871 DB - PRIME DP - Unbound Medicine ER -