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A stable isotope biomarker of marine food intake captures associations between n-3 fatty acid intake and chronic disease risk in a Yup'ik study population, and detects new associations with blood pressure and adiponectin.
J Nutr. 2014 May; 144(5):706-13.JN

Abstract

The nitrogen isotope ratio (δ(15)N) of RBCs has been proposed as a biomarker of marine food intake in Yup'ik people based on strong associations with RBC eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). However, EPA and DHA derive from marine fats, whereas elevated δ(15)N derives from marine protein, and these dietary components may have different biologic effects. Whether δ(15)N is similarly associated with chronic disease risk factors compared with RBC EPA and DHA is not known. We used covariate-adjusted linear models to describe biomarker associations with chronic disease risk factors in Yup'ik people, first in a smaller (n = 363) cross-sectional study population using RBC EPA, DHA, and δ(15)N, and then in a larger (n = 772) cross-sectional study population using δ(15)N only. In the smaller sample, associations of RBC EPA, DHA, and δ(15)N with obesity and chronic disease risk factors were similar in direction and significance: δ(15)N was positively associated with total, HDL, and LDL cholesterol, apolipoprotein A-I, and insulin-like growth factor binding protein-3 (IGFBP-3), and inversely associated with triglycerides. Based on comparisons between covariate-adjusted β-coefficients, EPA was more strongly associated with circulating lipids and lipoproteins, whereas δ(15)N was more strongly associated with adipokines, the inflammatory marker interleukin-6, and IGFBP-3. In the larger sample there were new findings for this population: δ(15)N was inversely associated with blood pressure and there was a significant association (with inverse linear and positive quadratic terms) with adiponectin. In conclusion, δ(15)N is a valid measure for evaluating associations between EPA and DHA intake and chronic disease risk in Yup'ik people and may be used in larger studies. By measuring δ(15)N, we report beneficial associations of marine food intake with blood pressure and adiponectin, which may contribute to a lower incidence of some chronic diseases in Yup'ik people.

Authors+Show Affiliations

Center for Alaska Native Health Research, Institute of Arctic Biology, and.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

24598880

Citation

O'Brien, Diane M., et al. "A Stable Isotope Biomarker of Marine Food Intake Captures Associations Between N-3 Fatty Acid Intake and Chronic Disease Risk in a Yup'ik Study Population, and Detects New Associations With Blood Pressure and Adiponectin." The Journal of Nutrition, vol. 144, no. 5, 2014, pp. 706-13.
O'Brien DM, Kristal AR, Nash SH, et al. A stable isotope biomarker of marine food intake captures associations between n-3 fatty acid intake and chronic disease risk in a Yup'ik study population, and detects new associations with blood pressure and adiponectin. J Nutr. 2014;144(5):706-13.
O'Brien, D. M., Kristal, A. R., Nash, S. H., Hopkins, S. E., Luick, B. R., Stanhope, K. L., Havel, P. J., & Boyer, B. B. (2014). A stable isotope biomarker of marine food intake captures associations between n-3 fatty acid intake and chronic disease risk in a Yup'ik study population, and detects new associations with blood pressure and adiponectin. The Journal of Nutrition, 144(5), 706-13. https://doi.org/10.3945/jn.113.189381
O'Brien DM, et al. A Stable Isotope Biomarker of Marine Food Intake Captures Associations Between N-3 Fatty Acid Intake and Chronic Disease Risk in a Yup'ik Study Population, and Detects New Associations With Blood Pressure and Adiponectin. J Nutr. 2014;144(5):706-13. PubMed PMID: 24598880.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A stable isotope biomarker of marine food intake captures associations between n-3 fatty acid intake and chronic disease risk in a Yup'ik study population, and detects new associations with blood pressure and adiponectin. AU - O'Brien,Diane M, AU - Kristal,Alan R, AU - Nash,Sarah H, AU - Hopkins,Scarlett E, AU - Luick,Bret R, AU - Stanhope,Kimber L, AU - Havel,Peter J, AU - Boyer,Bert B, Y1 - 2014/03/05/ PY - 2014/3/7/entrez PY - 2014/3/7/pubmed PY - 2014/6/11/medline SP - 706 EP - 13 JF - The Journal of nutrition JO - J Nutr VL - 144 IS - 5 N2 - The nitrogen isotope ratio (δ(15)N) of RBCs has been proposed as a biomarker of marine food intake in Yup'ik people based on strong associations with RBC eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). However, EPA and DHA derive from marine fats, whereas elevated δ(15)N derives from marine protein, and these dietary components may have different biologic effects. Whether δ(15)N is similarly associated with chronic disease risk factors compared with RBC EPA and DHA is not known. We used covariate-adjusted linear models to describe biomarker associations with chronic disease risk factors in Yup'ik people, first in a smaller (n = 363) cross-sectional study population using RBC EPA, DHA, and δ(15)N, and then in a larger (n = 772) cross-sectional study population using δ(15)N only. In the smaller sample, associations of RBC EPA, DHA, and δ(15)N with obesity and chronic disease risk factors were similar in direction and significance: δ(15)N was positively associated with total, HDL, and LDL cholesterol, apolipoprotein A-I, and insulin-like growth factor binding protein-3 (IGFBP-3), and inversely associated with triglycerides. Based on comparisons between covariate-adjusted β-coefficients, EPA was more strongly associated with circulating lipids and lipoproteins, whereas δ(15)N was more strongly associated with adipokines, the inflammatory marker interleukin-6, and IGFBP-3. In the larger sample there were new findings for this population: δ(15)N was inversely associated with blood pressure and there was a significant association (with inverse linear and positive quadratic terms) with adiponectin. In conclusion, δ(15)N is a valid measure for evaluating associations between EPA and DHA intake and chronic disease risk in Yup'ik people and may be used in larger studies. By measuring δ(15)N, we report beneficial associations of marine food intake with blood pressure and adiponectin, which may contribute to a lower incidence of some chronic diseases in Yup'ik people. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/24598880/A_stable_isotope_biomarker_of_marine_food_intake_captures_associations_between_n_3_fatty_acid_intake_and_chronic_disease_risk_in_a_Yup'ik_study_population_and_detects_new_associations_with_blood_pressure_and_adiponectin_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.113.189381 DB - PRIME DP - Unbound Medicine ER -