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Profile of levodopa-induced dyskinesia in patients of Parkinson's disease: a record based study.
Neurol Res. 2014 Sep; 36(9):841-6.NR

Abstract

OBJECTIVES

Levodopa-induced dyskinesia (LID) is one of the most disabling complications of long-term pharmacotherapy of Parkinson's disease (PD). The objective of our study was to examine the clinical profile and determinants of severity of LID in Indian PD patients on levodopa therapy.

METHODS

Retrospective analysis of records of PD patients with LID was performed. All patients were on levodopa and carbidopa combination. Records of subjects with complete information about disease profile, drug intake, and dyskinesia were analyzed. Characterization of LID was based on responses to part IV of unified Parkinson's disease rating scale (UPDRS).

RESULTS

Records of 42 patients (M∶F = 4·6∶1) were analyzed. The median Hoehn and Yahr (H&Y) stage was 2·5 while median duration of levodopa therapy was 6·16 years (range: 1·91-14·58). Early morning dystonia was reported by 97·6% of the patients. Patients treated with ≧2 concomitant PD medication reported a significantly lower median UPDRS IV A score compared to patients treated with <2 number of concomitant drugs. A trend toward a lower UPDRS IV A score was associated with use of dopamine agonists (DA). Patients with H&Y score ≧3 had a significantly higher median total UPDRS IV A score than patients with H&Y score <3.

DISCUSSION

Early morning dystonia might be more common among Indian patients of LID. Use of a higher number of concomitant PD medications alongside levodopa is associated with a reduced severity of dyskinesia, even on prolonged use. Levodopa-induced dyskinesia is not only a drug-related phenomenon but the stage of PD itself also affects the dyskinesia severity.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

24601722

Citation

Choudhury, Supriyo, et al. "Profile of Levodopa-induced Dyskinesia in Patients of Parkinson's Disease: a Record Based Study." Neurological Research, vol. 36, no. 9, 2014, pp. 841-6.
Choudhury S, Pradhan R, Paul P, et al. Profile of levodopa-induced dyskinesia in patients of Parkinson's disease: a record based study. Neurol Res. 2014;36(9):841-6.
Choudhury, S., Pradhan, R., Paul, P., Das, M., Gupta, A., Ghosh, P., & Chatterjee, S. (2014). Profile of levodopa-induced dyskinesia in patients of Parkinson's disease: a record based study. Neurological Research, 36(9), 841-6. https://doi.org/10.1179/1743132814Y.0000000339
Choudhury S, et al. Profile of Levodopa-induced Dyskinesia in Patients of Parkinson's Disease: a Record Based Study. Neurol Res. 2014;36(9):841-6. PubMed PMID: 24601722.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Profile of levodopa-induced dyskinesia in patients of Parkinson's disease: a record based study. AU - Choudhury,Supriyo, AU - Pradhan,Richeek, AU - Paul,Pritikanta, AU - Das,Manisha, AU - Gupta,Anupam, AU - Ghosh,Pahari, AU - Chatterjee,Suparna, Y1 - 2014/03/07/ PY - 2014/3/8/entrez PY - 2014/3/8/pubmed PY - 2015/3/31/medline KW - Disease severity KW - Dyskinesia, KW - Levodopa, KW - Levodopa-induced dyskinesia, KW - Parkinson's disease, SP - 841 EP - 6 JF - Neurological research JO - Neurol Res VL - 36 IS - 9 N2 - OBJECTIVES: Levodopa-induced dyskinesia (LID) is one of the most disabling complications of long-term pharmacotherapy of Parkinson's disease (PD). The objective of our study was to examine the clinical profile and determinants of severity of LID in Indian PD patients on levodopa therapy. METHODS: Retrospective analysis of records of PD patients with LID was performed. All patients were on levodopa and carbidopa combination. Records of subjects with complete information about disease profile, drug intake, and dyskinesia were analyzed. Characterization of LID was based on responses to part IV of unified Parkinson's disease rating scale (UPDRS). RESULTS: Records of 42 patients (M∶F = 4·6∶1) were analyzed. The median Hoehn and Yahr (H&Y) stage was 2·5 while median duration of levodopa therapy was 6·16 years (range: 1·91-14·58). Early morning dystonia was reported by 97·6% of the patients. Patients treated with ≧2 concomitant PD medication reported a significantly lower median UPDRS IV A score compared to patients treated with <2 number of concomitant drugs. A trend toward a lower UPDRS IV A score was associated with use of dopamine agonists (DA). Patients with H&Y score ≧3 had a significantly higher median total UPDRS IV A score than patients with H&Y score <3. DISCUSSION: Early morning dystonia might be more common among Indian patients of LID. Use of a higher number of concomitant PD medications alongside levodopa is associated with a reduced severity of dyskinesia, even on prolonged use. Levodopa-induced dyskinesia is not only a drug-related phenomenon but the stage of PD itself also affects the dyskinesia severity. SN - 1743-1328 UR - https://www.unboundmedicine.com/medline/citation/24601722/Profile_of_levodopa_induced_dyskinesia_in_patients_of_Parkinson's_disease:_a_record_based_study_ L2 - https://www.tandfonline.com/doi/full/10.1179/1743132814Y.0000000339 DB - PRIME DP - Unbound Medicine ER -