Tags

Type your tag names separated by a space and hit enter

[Hypofibrinogenemia caused by long-term administration of hemocoagulase: three cases report and literature review].
Zhonghua Xue Ye Xue Za Zhi. 2014 Jan; 35(1):50-2.ZX

Abstract

OBJECTIVE

A first report of 3 patients who developed hypofibrinogenemia due to long-term administration of hemocoagulase.

METHODS

The clinical data of three patients with hypofibrinogenemia due to long-term administration of hemocoagulase were analyzed, and the related literature was reviewed.

RESULTS

Case 1, a two-year old girl, had liver traumatic rupture and then treated with massive transfusion and fibrinogen infusion in addition to intravenous recombinant factor VIIa (two times) and hemocoagulase (2 U/d). The liver wound bleeding was soon stopped. However, her plasma fibrinogen level decreased to 0.12 g/L after continuous administration of hemocoagulase for 18 days. Case 2, a three-year old boy, had liver traumatic rupture and was treated with surgical repair, and then received hemocoagulase (2 U/d). On the 8th day, a large amount of blood was found to exude from abdominal cavity drainage tube and indwelling venous catheter, and his fibrinogen dropped to 0.24 g/L. Case 3 was a 45 year-old man who underwent a total mandibular resection because of malignant tumor, and he was given hemocoagulase (4 U/d). A continuous blood oozing was noted from his operation incision, and his fibrinogen level decreased to 0.25 g/L. All the three patients'plasma fibrinogen levels and coagulation tests returned to normal ranges after discontinuation of hemocoagulase administration and supplement of fibrinogen, and the bleeding stopped in cases 2 and 3.

CONCLUSION

Long-term use of hemocoagulase could induce hypofibrinogenemia and severe bleeding.

Authors+Show Affiliations

Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.

Pub Type(s)

Case Reports
English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

24602733

Citation

Wang, Zhaoyue, et al. "[Hypofibrinogenemia Caused By Long-term Administration of Hemocoagulase: Three Cases Report and Literature Review]." Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi, vol. 35, no. 1, 2014, pp. 50-2.
Wang Z, Li J, Cao L, et al. [Hypofibrinogenemia caused by long-term administration of hemocoagulase: three cases report and literature review]. Zhonghua Xue Ye Xue Za Zhi. 2014;35(1):50-2.
Wang, Z., Li, J., Cao, L., Yu, Z., Bai, X., & Ruan, C. (2014). [Hypofibrinogenemia caused by long-term administration of hemocoagulase: three cases report and literature review]. Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi, 35(1), 50-2. https://doi.org/10.3760/cma.j.issn.0253-2727.2014.01.013
Wang Z, et al. [Hypofibrinogenemia Caused By Long-term Administration of Hemocoagulase: Three Cases Report and Literature Review]. Zhonghua Xue Ye Xue Za Zhi. 2014;35(1):50-2. PubMed PMID: 24602733.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Hypofibrinogenemia caused by long-term administration of hemocoagulase: three cases report and literature review]. AU - Wang,Zhaoyue, AU - Li,Jianqin, AU - Cao,Lijuan, AU - Yu,Ziqiang, AU - Bai,Xia, AU - Ruan,Changgeng, PY - 2014/3/8/entrez PY - 2014/3/8/pubmed PY - 2015/2/20/medline SP - 50 EP - 2 JF - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi JO - Zhonghua Xue Ye Xue Za Zhi VL - 35 IS - 1 N2 - OBJECTIVE: A first report of 3 patients who developed hypofibrinogenemia due to long-term administration of hemocoagulase. METHODS: The clinical data of three patients with hypofibrinogenemia due to long-term administration of hemocoagulase were analyzed, and the related literature was reviewed. RESULTS: Case 1, a two-year old girl, had liver traumatic rupture and then treated with massive transfusion and fibrinogen infusion in addition to intravenous recombinant factor VIIa (two times) and hemocoagulase (2 U/d). The liver wound bleeding was soon stopped. However, her plasma fibrinogen level decreased to 0.12 g/L after continuous administration of hemocoagulase for 18 days. Case 2, a three-year old boy, had liver traumatic rupture and was treated with surgical repair, and then received hemocoagulase (2 U/d). On the 8th day, a large amount of blood was found to exude from abdominal cavity drainage tube and indwelling venous catheter, and his fibrinogen dropped to 0.24 g/L. Case 3 was a 45 year-old man who underwent a total mandibular resection because of malignant tumor, and he was given hemocoagulase (4 U/d). A continuous blood oozing was noted from his operation incision, and his fibrinogen level decreased to 0.25 g/L. All the three patients'plasma fibrinogen levels and coagulation tests returned to normal ranges after discontinuation of hemocoagulase administration and supplement of fibrinogen, and the bleeding stopped in cases 2 and 3. CONCLUSION: Long-term use of hemocoagulase could induce hypofibrinogenemia and severe bleeding. SN - 0253-2727 UR - https://www.unboundmedicine.com/medline/citation/24602733/[Hypofibrinogenemia_caused_by_long_term_administration_of_hemocoagulase:_three_cases_report_and_literature_review]_ DB - PRIME DP - Unbound Medicine ER -