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Tracking of fetal growth characteristics during different trimesters and the risks of adverse birth outcomes.
Int J Epidemiol. 2014 Aug; 43(4):1140-53.IJ

Abstract

BACKGROUND

Fetal growth characteristics are used to identify influences of several maternal characteristics and to identify individuals at increased risk of adverse outcomes. The extent to which fetal growth characteristics track in different trimesters is not known.

METHODS

In a population-based prospective cohort study among 8636 pregnant women, we examined the extent to which fetal growth characteristics track, are influenced by maternal socio-demographic and lifestyle related determinants and are associated with birth outcomes. Fetal growth was assessed in each trimester and at birth.

RESULTS

Correlation coefficient between first-trimester crown-rump length and birthweight was r = 0.12 (P-value < 0.05). Correlation coefficients for fetal-head circumference, (femur) length and (estimated) fetal weight ranged from r = 0.16 to r = 0.30 (all P-values < 0.05) between second trimester and birth and from r = 0.36 to r = 0.58 (all P-values < 0.05) between third trimester and birth, and were highest for (estimated) fetal weight. Correlation coefficients for (estimated) fetal weight tended to be lower among overweight mothers, as compared with normal weight mothers, but were not influenced by other maternal characteristics. First, second and third-trimester fetal growth characteristics were associated with risks of preterm birth and small size for gestational age at birth,with the strongest associations present in third trimester.

CONCLUSION

Fetal growth characteristics track moderately throughout gestation, with stronger tracking coefficients present in later pregnancy. Tracking coefficients were not materially influenced by maternal socio-demographic and lifestyle characteristics. First, second and third trimester fetal growth characteristics were associated with the risk of adverse birth outcomes.

Authors+Show Affiliations

Generation R Study Group, and Departments of Epidemiology, Paediatrics and Obstetrics and Gynaecology, Erasmus Medical Center, Rotterdam, The NetherlandsGeneration R Study Group, and Departments of Epidemiology, Paediatrics and Obstetrics and Gynaecology, Erasmus Medical Center, Rotterdam, The NetherlandsGeneration R Study Group, and Departments of Epidemiology, Paediatrics and Obstetrics and Gynaecology, Erasmus Medical Center, Rotterdam, The Netherlands.Generation R Study Group, and Departments of Epidemiology, Paediatrics and Obstetrics and Gynaecology, Erasmus Medical Center, Rotterdam, The Netherlands.Generation R Study Group, and Departments of Epidemiology, Paediatrics and Obstetrics and Gynaecology, Erasmus Medical Center, Rotterdam, The Netherlands.Generation R Study Group, and Departments of Epidemiology, Paediatrics and Obstetrics and Gynaecology, Erasmus Medical Center, Rotterdam, The Netherlands.Generation R Study Group, and Departments of Epidemiology, Paediatrics and Obstetrics and Gynaecology, Erasmus Medical Center, Rotterdam, The NetherlandsGeneration R Study Group, and Departments of Epidemiology, Paediatrics and Obstetrics and Gynaecology, Erasmus Medical Center, Rotterdam, The NetherlandsGeneration R Study Group, and Departments of Epidemiology, Paediatrics and Obstetrics and Gynaecology, Erasmus Medical Center, Rotterdam, The Netherlands v.jaddoe@erasmusmc.nl.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24603318

Citation

Gaillard, Romy, et al. "Tracking of Fetal Growth Characteristics During Different Trimesters and the Risks of Adverse Birth Outcomes." International Journal of Epidemiology, vol. 43, no. 4, 2014, pp. 1140-53.
Gaillard R, Steegers EA, de Jongste JC, et al. Tracking of fetal growth characteristics during different trimesters and the risks of adverse birth outcomes. Int J Epidemiol. 2014;43(4):1140-53.
Gaillard, R., Steegers, E. A., de Jongste, J. C., Hofman, A., & Jaddoe, V. W. (2014). Tracking of fetal growth characteristics during different trimesters and the risks of adverse birth outcomes. International Journal of Epidemiology, 43(4), 1140-53. https://doi.org/10.1093/ije/dyu036
Gaillard R, et al. Tracking of Fetal Growth Characteristics During Different Trimesters and the Risks of Adverse Birth Outcomes. Int J Epidemiol. 2014;43(4):1140-53. PubMed PMID: 24603318.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tracking of fetal growth characteristics during different trimesters and the risks of adverse birth outcomes. AU - Gaillard,Romy, AU - Steegers,Eric Ap, AU - de Jongste,Johan C, AU - Hofman,Albert, AU - Jaddoe,Vincent Wv, Y1 - 2014/03/05/ PY - 2014/3/8/entrez PY - 2014/3/8/pubmed PY - 2015/7/15/medline KW - Fetal growth KW - cohort study KW - preterm birth KW - small size for gestational age KW - tracking SP - 1140 EP - 53 JF - International journal of epidemiology JO - Int J Epidemiol VL - 43 IS - 4 N2 - BACKGROUND: Fetal growth characteristics are used to identify influences of several maternal characteristics and to identify individuals at increased risk of adverse outcomes. The extent to which fetal growth characteristics track in different trimesters is not known. METHODS: In a population-based prospective cohort study among 8636 pregnant women, we examined the extent to which fetal growth characteristics track, are influenced by maternal socio-demographic and lifestyle related determinants and are associated with birth outcomes. Fetal growth was assessed in each trimester and at birth. RESULTS: Correlation coefficient between first-trimester crown-rump length and birthweight was r = 0.12 (P-value < 0.05). Correlation coefficients for fetal-head circumference, (femur) length and (estimated) fetal weight ranged from r = 0.16 to r = 0.30 (all P-values < 0.05) between second trimester and birth and from r = 0.36 to r = 0.58 (all P-values < 0.05) between third trimester and birth, and were highest for (estimated) fetal weight. Correlation coefficients for (estimated) fetal weight tended to be lower among overweight mothers, as compared with normal weight mothers, but were not influenced by other maternal characteristics. First, second and third-trimester fetal growth characteristics were associated with risks of preterm birth and small size for gestational age at birth,with the strongest associations present in third trimester. CONCLUSION: Fetal growth characteristics track moderately throughout gestation, with stronger tracking coefficients present in later pregnancy. Tracking coefficients were not materially influenced by maternal socio-demographic and lifestyle characteristics. First, second and third trimester fetal growth characteristics were associated with the risk of adverse birth outcomes. SN - 1464-3685 UR - https://www.unboundmedicine.com/medline/citation/24603318/Tracking_of_fetal_growth_characteristics_during_different_trimesters_and_the_risks_of_adverse_birth_outcomes_ L2 - https://academic.oup.com/ije/article-lookup/doi/10.1093/ije/dyu036 DB - PRIME DP - Unbound Medicine ER -