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Serum 25-hydroxyvitamin D concentration and inflammatory bowel disease characteristics in Romania.

Abstract

AIM

To describe the relationship between vitamin D levels and inflammatory bowel disease (IBD) characteristics in northeastern Romanian patients.

METHODS

This was a prospective study of 47 consecutive IBD patients admitted to The Institute of Gastroenterology and Hepatology in Iasi, Romania between March 2011 and June 2012. The diagnosis of IBD was established based on endoscopic, histologic and radiologic findings. Demographic data, disease characteristics, ongoing treatments and biological parameters of patients (including markers of inflammation: C-reactive protein level, fibrinogen level, and erythrocyte sedimentation rate) were recorded. Serum vitamin D levels were measured and compared with age- and sex-matched healthy volunteers from the same geographic area. Vitamin D levels were defined as sufficient (> 30 ng/mL), insufficient (20-30 ng/mL), or severely deficient (< 20 ng/mL).

RESULTS

Thirty-three of the IBD patients included in this study had ulcerative colitis (UC) and 14 had Crohn's disease (CD). Only 24% of the UC patients and 21% of the CD patients had sufficient vitamin D levels. The vitamin D levels were significantly lower in the CD patients with moderate to severe disease activity compared to the CD patients in remission or with mild disease activity (16 ± 6 ng/mL vs 26 ± 7 ng/mL; 16 ± 6 ng/mL vs 31 ± 9 ng/mL, respectively, P < 0.05). Vitamin D levels in the UC patients were not influenced by disease activity and no correlation was observed with the inflammation markers tested (C-reactive protein, fibrinogen, and erythrocyte sedimentation rate). No association was observed between vitamin D levels and smoking status or ongoing medication (5ASA, steroids, and anti-TNFα). Newly diagnosed IBD patients had lower vitamin D levels than patients with established cases, though these differences were not significant (UC: 22 ± 9 ng/mL vs 26 ± 12 ng/mL; CD: 18 ± 6 ng/mL vs 27 ± 11 ng/mL, respectively). Although no association was found between the season during which the visit was scheduled and vitamin D levels, the UC patients assessed during the winter tended to have lower levels than those assessed during the summer (22 ± 9 ng/mL vs 28 ± 13 ng/mL, respectively).

CONCLUSION

Vitamin D levels are significantly reduced in IBD patients in northeastern Romania, with the lowest levels occurring in CD patients with moderate to severe disease activity.

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  • Authors+Show Affiliations

    ,

    Gabriela Dumitrescu, Catalina Mihai, Mihaela Dranga, Cristina Cijevschi Prelipcean, Department of Medical Sciences, Grigore T. Popa University of Medicine and Pharmacy, Iasi 700115, Romania.

    ,

    Gabriela Dumitrescu, Catalina Mihai, Mihaela Dranga, Cristina Cijevschi Prelipcean, Department of Medical Sciences, Grigore T. Popa University of Medicine and Pharmacy, Iasi 700115, Romania.

    ,

    Gabriela Dumitrescu, Catalina Mihai, Mihaela Dranga, Cristina Cijevschi Prelipcean, Department of Medical Sciences, Grigore T. Popa University of Medicine and Pharmacy, Iasi 700115, Romania.

    Gabriela Dumitrescu, Catalina Mihai, Mihaela Dranga, Cristina Cijevschi Prelipcean, Department of Medical Sciences, Grigore T. Popa University of Medicine and Pharmacy, Iasi 700115, Romania.

    Source

    World journal of gastroenterology 20:9 2014 Mar 07 pg 2392-6

    MeSH

    Adult
    Biomarkers
    Case-Control Studies
    Colitis, Ulcerative
    Crohn Disease
    Humans
    Incidence
    Middle Aged
    Prospective Studies
    Risk Factors
    Romania
    Seasons
    Severity of Illness Index
    Time Factors
    Vitamin D
    Vitamin D Deficiency

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24605037

    Citation

    Dumitrescu, Gabriela, et al. "Serum 25-hydroxyvitamin D Concentration and Inflammatory Bowel Disease Characteristics in Romania." World Journal of Gastroenterology, vol. 20, no. 9, 2014, pp. 2392-6.
    Dumitrescu G, Mihai C, Dranga M, et al. Serum 25-hydroxyvitamin D concentration and inflammatory bowel disease characteristics in Romania. World J Gastroenterol. 2014;20(9):2392-6.
    Dumitrescu, G., Mihai, C., Dranga, M., & Prelipcean, C. C. (2014). Serum 25-hydroxyvitamin D concentration and inflammatory bowel disease characteristics in Romania. World Journal of Gastroenterology, 20(9), pp. 2392-6. doi:10.3748/wjg.v20.i9.2392.
    Dumitrescu G, et al. Serum 25-hydroxyvitamin D Concentration and Inflammatory Bowel Disease Characteristics in Romania. World J Gastroenterol. 2014 Mar 7;20(9):2392-6. PubMed PMID: 24605037.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Serum 25-hydroxyvitamin D concentration and inflammatory bowel disease characteristics in Romania. AU - Dumitrescu,Gabriela, AU - Mihai,Catalina, AU - Dranga,Mihaela, AU - Prelipcean,Cristina Cijevschi, PY - 2013/08/27/received PY - 2013/12/11/revised PY - 2014/01/03/accepted PY - 2014/3/8/entrez PY - 2014/3/8/pubmed PY - 2015/4/7/medline KW - Crohn’s disease activity KW - Inflammatory bowel disease KW - Northeastern Romania KW - Seasonality KW - Vitamin D level SP - 2392 EP - 6 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 20 IS - 9 N2 - AIM: To describe the relationship between vitamin D levels and inflammatory bowel disease (IBD) characteristics in northeastern Romanian patients. METHODS: This was a prospective study of 47 consecutive IBD patients admitted to The Institute of Gastroenterology and Hepatology in Iasi, Romania between March 2011 and June 2012. The diagnosis of IBD was established based on endoscopic, histologic and radiologic findings. Demographic data, disease characteristics, ongoing treatments and biological parameters of patients (including markers of inflammation: C-reactive protein level, fibrinogen level, and erythrocyte sedimentation rate) were recorded. Serum vitamin D levels were measured and compared with age- and sex-matched healthy volunteers from the same geographic area. Vitamin D levels were defined as sufficient (> 30 ng/mL), insufficient (20-30 ng/mL), or severely deficient (< 20 ng/mL). RESULTS: Thirty-three of the IBD patients included in this study had ulcerative colitis (UC) and 14 had Crohn's disease (CD). Only 24% of the UC patients and 21% of the CD patients had sufficient vitamin D levels. The vitamin D levels were significantly lower in the CD patients with moderate to severe disease activity compared to the CD patients in remission or with mild disease activity (16 ± 6 ng/mL vs 26 ± 7 ng/mL; 16 ± 6 ng/mL vs 31 ± 9 ng/mL, respectively, P < 0.05). Vitamin D levels in the UC patients were not influenced by disease activity and no correlation was observed with the inflammation markers tested (C-reactive protein, fibrinogen, and erythrocyte sedimentation rate). No association was observed between vitamin D levels and smoking status or ongoing medication (5ASA, steroids, and anti-TNFα). Newly diagnosed IBD patients had lower vitamin D levels than patients with established cases, though these differences were not significant (UC: 22 ± 9 ng/mL vs 26 ± 12 ng/mL; CD: 18 ± 6 ng/mL vs 27 ± 11 ng/mL, respectively). Although no association was found between the season during which the visit was scheduled and vitamin D levels, the UC patients assessed during the winter tended to have lower levels than those assessed during the summer (22 ± 9 ng/mL vs 28 ± 13 ng/mL, respectively). CONCLUSION: Vitamin D levels are significantly reduced in IBD patients in northeastern Romania, with the lowest levels occurring in CD patients with moderate to severe disease activity. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/24605037/Serum_25_hydroxyvitamin_D_concentration_and_inflammatory_bowel_disease_characteristics_in_Romania_ L2 - http://www.wjgnet.com/1007-9327/full/v20/i9/2392.htm DB - PRIME DP - Unbound Medicine ER -