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Effect of low-fat diet on breast cancer survival: a meta-analysis.

Abstract

BACKGROUND

Even though many studies have examined the possible effect of low-fat diet on breast cancer survival, the relationship remains unclear.

OBJECTIVES

To summarize the current evidence about the effect of post-diagnostic low-fat diet on recurrence and all-cause mortality of breast cancer.

METHODS

We conducted a search of Pubmed, Embase, Web of Science, and Cochrane Library and as a result two randomized controlled trials (RCT) and one large multi-center prospective cohort study with 9,966 breast cancer patients were included in this report.

RESULTS

Post-diagnostic low-fat diet reduced risk of recurrence of breast cancer by 23% (HR=0.77, 95%CI 0.63 to 0.94, P=0.009) and all cause mortality of breast cancer by 17% (HR=0.83, 95%CI 0.69 to 1.00, P=0.05).

CONCLUSIONS

This meta-analysis suggested the post-diagnostic low-fat diet can improve breast cancer survival by reducing risk of recurrence. However, more trials of the relationship between low-fat diet and all- cause mortality of breast cancer are still needed.

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  • Authors+Show Affiliations

    ,

    Library of the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China E-mail : peggyxsz@gmail.com.

    ,

    Source

    MeSH

    Breast Neoplasms
    Diet, Fat-Restricted
    Female
    Humans
    Neoplasm Recurrence, Local
    Treatment Outcome

    Pub Type(s)

    Journal Article
    Meta-Analysis

    Language

    eng

    PubMed ID

    24606431

    Citation

    Xing, Mei-Yuan, et al. "Effect of Low-fat Diet On Breast Cancer Survival: a Meta-analysis." Asian Pacific Journal of Cancer Prevention : APJCP, vol. 15, no. 3, 2014, pp. 1141-4.
    Xing MY, Xu SZ, Shen P. Effect of low-fat diet on breast cancer survival: a meta-analysis. Asian Pac J Cancer Prev. 2014;15(3):1141-4.
    Xing, M. Y., Xu, S. Z., & Shen, P. (2014). Effect of low-fat diet on breast cancer survival: a meta-analysis. Asian Pacific Journal of Cancer Prevention : APJCP, 15(3), pp. 1141-4.
    Xing MY, Xu SZ, Shen P. Effect of Low-fat Diet On Breast Cancer Survival: a Meta-analysis. Asian Pac J Cancer Prev. 2014;15(3):1141-4. PubMed PMID: 24606431.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of low-fat diet on breast cancer survival: a meta-analysis. AU - Xing,Mei-Yuan, AU - Xu,Su-Zhen, AU - Shen,Peng, PY - 2014/3/11/entrez PY - 2014/3/13/pubmed PY - 2014/11/19/medline SP - 1141 EP - 4 JF - Asian Pacific journal of cancer prevention : APJCP JO - Asian Pac. J. Cancer Prev. VL - 15 IS - 3 N2 - BACKGROUND: Even though many studies have examined the possible effect of low-fat diet on breast cancer survival, the relationship remains unclear. OBJECTIVES: To summarize the current evidence about the effect of post-diagnostic low-fat diet on recurrence and all-cause mortality of breast cancer. METHODS: We conducted a search of Pubmed, Embase, Web of Science, and Cochrane Library and as a result two randomized controlled trials (RCT) and one large multi-center prospective cohort study with 9,966 breast cancer patients were included in this report. RESULTS: Post-diagnostic low-fat diet reduced risk of recurrence of breast cancer by 23% (HR=0.77, 95%CI 0.63 to 0.94, P=0.009) and all cause mortality of breast cancer by 17% (HR=0.83, 95%CI 0.69 to 1.00, P=0.05). CONCLUSIONS: This meta-analysis suggested the post-diagnostic low-fat diet can improve breast cancer survival by reducing risk of recurrence. However, more trials of the relationship between low-fat diet and all- cause mortality of breast cancer are still needed. SN - 2476-762X UR - https://www.unboundmedicine.com/medline/citation/24606431/full_citation L2 - http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:24606431&key=2014.15.3.1141 DB - PRIME DP - Unbound Medicine ER -