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Hydrogen sulfide and cell signaling: team player or referee?
Plant Physiol Biochem. 2014 May; 78:37-42.PP

Abstract

Hydrogen sulfide (H2S) has been postulated to be the third gasotransmitter, and along with other reactive compounds such as reactive oxygen species (ROS) and nitric oxide (NO) it is thought to be a key signalling molecule. Enzymes which generate H2S, and remove it, have been characterised in both plants and animals and although it is inherently toxic to cells - inhibiting cytochrome oxidase for example - H2S is now being thought of as part of signal transduction pathways. But is it working as a signal in the sense usually seen for small signalling molecules, that is, produced when needed, perceived and leading to dedicated responses in cells? A look through the literature shows that H2S is involved in many stress responses, and in animals is implicated in the onset of many diseases, in both cases where ROS and NO are often involved. It is suggested here that H2S is not acting as a true signal, but through its interaction with NO and ROS metabolism is modulating such activity, keeping it in check unless strictly needed, and that H2S is acting as a referee to ensure NO and ROS metabolism is working properly.

Authors+Show Affiliations

Faculty of Health and Applied Sciences, University of the West of England, Coldharbour Lane, Bristol BS16 1QY, UK. Electronic address: john.hancock@uwe.ac.uk.University of Exeter Medical School, University of Exeter, Exeter, UK.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24607577

Citation

Hancock, J T., and M Whiteman. "Hydrogen Sulfide and Cell Signaling: Team Player or Referee?" Plant Physiology and Biochemistry : PPB, vol. 78, 2014, pp. 37-42.
Hancock JT, Whiteman M. Hydrogen sulfide and cell signaling: team player or referee? Plant Physiol Biochem. 2014;78:37-42.
Hancock, J. T., & Whiteman, M. (2014). Hydrogen sulfide and cell signaling: team player or referee? Plant Physiology and Biochemistry : PPB, 78, 37-42. https://doi.org/10.1016/j.plaphy.2014.02.012
Hancock JT, Whiteman M. Hydrogen Sulfide and Cell Signaling: Team Player or Referee. Plant Physiol Biochem. 2014;78:37-42. PubMed PMID: 24607577.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hydrogen sulfide and cell signaling: team player or referee? AU - Hancock,J T, AU - Whiteman,M, Y1 - 2014/02/25/ PY - 2014/02/04/received PY - 2014/02/16/accepted PY - 2014/3/11/entrez PY - 2014/3/13/pubmed PY - 2014/12/17/medline KW - Glutathione KW - Hydrogen peroxide KW - Hydrogen sulfide KW - Nitric oxide KW - Signal transduction KW - Thiol modifications SP - 37 EP - 42 JF - Plant physiology and biochemistry : PPB JO - Plant Physiol Biochem VL - 78 N2 - Hydrogen sulfide (H2S) has been postulated to be the third gasotransmitter, and along with other reactive compounds such as reactive oxygen species (ROS) and nitric oxide (NO) it is thought to be a key signalling molecule. Enzymes which generate H2S, and remove it, have been characterised in both plants and animals and although it is inherently toxic to cells - inhibiting cytochrome oxidase for example - H2S is now being thought of as part of signal transduction pathways. But is it working as a signal in the sense usually seen for small signalling molecules, that is, produced when needed, perceived and leading to dedicated responses in cells? A look through the literature shows that H2S is involved in many stress responses, and in animals is implicated in the onset of many diseases, in both cases where ROS and NO are often involved. It is suggested here that H2S is not acting as a true signal, but through its interaction with NO and ROS metabolism is modulating such activity, keeping it in check unless strictly needed, and that H2S is acting as a referee to ensure NO and ROS metabolism is working properly. SN - 1873-2690 UR - https://www.unboundmedicine.com/medline/citation/24607577/Hydrogen_sulfide_and_cell_signaling:_team_player_or_referee L2 - https://linkinghub.elsevier.com/retrieve/pii/S0981-9428(14)00056-4 DB - PRIME DP - Unbound Medicine ER -