Tags

Type your tag names separated by a space and hit enter

Motor, psychiatric and fatigue features associated with nutritional status and its effects on quality of life in Parkinson's disease patients.
PLoS One. 2014; 9(3):e91153.Plos

Abstract

OBJECTIVES

Parkinson's disease (PD) patients are more likely to develop impaired nutritional status because of the symptoms, medications and complications of the disease. However, little is known about the determinants and consequences of malnutrition in PD. This study aimed to investigate the association of motor, psychiatric and fatigue features with nutritional status as well as the effects of malnutrition on different aspects of quality of life (QoL) in PD patients.

METHODS

One hundred and fifty patients with idiopathic PD (IPD) were recruited in this study. A demographic checklist, the Unified Parkinson's Disease Rating Scale (UPDRS), the Hospital Anxiety and Depression Scale (HADS) and the Fatigue Severity Scale (FSS) were completed through face-to-face interviews and clinical examinations. The health-related QoL (HRQoL) was also evaluated by means of the Parkinson's Disease Questionnaire (PDQ-39). For evaluation of nutritional status, the Mini Nutritional Assessment (MNA) questionnaire was applied together with anthropometric measurements.

RESULTS

Thirty seven (25.3%) patients were at risk of malnutrition and another 3 (2.1%) were malnourished. The total score of the UPDRS scale (r = -0.613, P<0.001) and PD duration (r = -0.284, P = 0.002) had a significant inverse correlation with the total MNA score. The median score of the Hoehn and Yahr stage was significantly higher in PD patients with abnormal nutritional status [2.5 vs. 2.0; P<0.001]. More severe anxiety [8.8 vs. 5.9; P = 0.002], depression [9.0 vs. 3.6; P<0.001] and fatigue [5.4 vs. 4.2; P<0.001] were observed in PD patients with abnormal nutritional status. Except for stigma, all other domains of the PDQ-39 were significantly correlated with the total score of the MNA.

CONCLUSION

Our study demonstrates that disease duration, severity of motor and psychiatric symptoms (depression, anxiety) and fatigue are associated with nutritional status in PD. Different aspects of the HRQoL were affected by patients' nutritional status especially the emotional well-being and mobility domains.

Authors+Show Affiliations

Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society (NVS), Karolinska Institutet, Stockholm, Sweden; Firoozgar Clinical Research Development Center (FCRDC), Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.Medical Students Research Committee (MSRC), Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.Movement Disorders Clinic, Department of Neurology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society (NVS), Karolinska Institutet, Stockholm, Sweden; Aging Research Center, Sabzevar University of Medical Sciences, Sabzevar, Khorasan, Iran.Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society (NVS), Karolinska Institutet, Stockholm, Sweden; Department of Geriatric Medicine, Karolinska University Hospital, Stockholm, Sweden.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24608130

Citation

Fereshtehnejad, Seyed-Mohammad, et al. "Motor, Psychiatric and Fatigue Features Associated With Nutritional Status and Its Effects On Quality of Life in Parkinson's Disease Patients." PloS One, vol. 9, no. 3, 2014, pp. e91153.
Fereshtehnejad SM, Ghazi L, Shafieesabet M, et al. Motor, psychiatric and fatigue features associated with nutritional status and its effects on quality of life in Parkinson's disease patients. PLoS One. 2014;9(3):e91153.
Fereshtehnejad, S. M., Ghazi, L., Shafieesabet, M., Shahidi, G. A., Delbari, A., & Lökk, J. (2014). Motor, psychiatric and fatigue features associated with nutritional status and its effects on quality of life in Parkinson's disease patients. PloS One, 9(3), e91153. https://doi.org/10.1371/journal.pone.0091153
Fereshtehnejad SM, et al. Motor, Psychiatric and Fatigue Features Associated With Nutritional Status and Its Effects On Quality of Life in Parkinson's Disease Patients. PLoS One. 2014;9(3):e91153. PubMed PMID: 24608130.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Motor, psychiatric and fatigue features associated with nutritional status and its effects on quality of life in Parkinson's disease patients. AU - Fereshtehnejad,Seyed-Mohammad, AU - Ghazi,Ladan, AU - Shafieesabet,Mahdiyeh, AU - Shahidi,Gholam Ali, AU - Delbari,Ahmad, AU - Lökk,Johan, Y1 - 2014/03/07/ PY - 2013/08/06/received PY - 2014/02/10/accepted PY - 2014/3/11/entrez PY - 2014/3/13/pubmed PY - 2015/2/24/medline SP - e91153 EP - e91153 JF - PloS one JO - PLoS One VL - 9 IS - 3 N2 - OBJECTIVES: Parkinson's disease (PD) patients are more likely to develop impaired nutritional status because of the symptoms, medications and complications of the disease. However, little is known about the determinants and consequences of malnutrition in PD. This study aimed to investigate the association of motor, psychiatric and fatigue features with nutritional status as well as the effects of malnutrition on different aspects of quality of life (QoL) in PD patients. METHODS: One hundred and fifty patients with idiopathic PD (IPD) were recruited in this study. A demographic checklist, the Unified Parkinson's Disease Rating Scale (UPDRS), the Hospital Anxiety and Depression Scale (HADS) and the Fatigue Severity Scale (FSS) were completed through face-to-face interviews and clinical examinations. The health-related QoL (HRQoL) was also evaluated by means of the Parkinson's Disease Questionnaire (PDQ-39). For evaluation of nutritional status, the Mini Nutritional Assessment (MNA) questionnaire was applied together with anthropometric measurements. RESULTS: Thirty seven (25.3%) patients were at risk of malnutrition and another 3 (2.1%) were malnourished. The total score of the UPDRS scale (r = -0.613, P<0.001) and PD duration (r = -0.284, P = 0.002) had a significant inverse correlation with the total MNA score. The median score of the Hoehn and Yahr stage was significantly higher in PD patients with abnormal nutritional status [2.5 vs. 2.0; P<0.001]. More severe anxiety [8.8 vs. 5.9; P = 0.002], depression [9.0 vs. 3.6; P<0.001] and fatigue [5.4 vs. 4.2; P<0.001] were observed in PD patients with abnormal nutritional status. Except for stigma, all other domains of the PDQ-39 were significantly correlated with the total score of the MNA. CONCLUSION: Our study demonstrates that disease duration, severity of motor and psychiatric symptoms (depression, anxiety) and fatigue are associated with nutritional status in PD. Different aspects of the HRQoL were affected by patients' nutritional status especially the emotional well-being and mobility domains. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/24608130/Motor_psychiatric_and_fatigue_features_associated_with_nutritional_status_and_its_effects_on_quality_of_life_in_Parkinson's_disease_patients_ L2 - https://dx.plos.org/10.1371/journal.pone.0091153 DB - PRIME DP - Unbound Medicine ER -