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Persistent presence of the anti-myelin oligodendrocyte glycoprotein autoantibody in a pediatric case of acute disseminated encephalomyelitis followed by optic neuritis.
Neuropediatrics. 2014 Jun; 45(3):196-9.N

Abstract

We report the case of a 5-year-old Japanese girl who initially had acute disseminated encephalomyelitis (ADEM) and was positive for the myelin oligodendrocyte glycoprotein (MOG) antibodies and developed unilateral optic neuritis (ON) 71 days after ADEM onset. The patient's serum was positive for the anti-MOG antibodies from the onset of ADEM to the development of ON. This phenotype has been reported in only two previous articles, and the specific mechanism of action of the anti-MOG antibodies is not yet understood. Our case suggests that the anti-MOG antibody can be associated with the pathogenesis of ADEM followed by ON. Thus, patients with ADEM who test positive for the anti-MOG antibody may be at risk of developing subsequent ON.

Authors+Show Affiliations

Department of Pediatrics, Jichi Medical University, Shimotsuke, Tochigi, Japan.Department of Pediatrics, Jichi Medical University, Shimotsuke, Tochigi, Japan.Department of Ophthalmology, Jichi Medical University, Shimotsuke, Tochigi, Japan.Department of Pediatrics, Jichi Medical University, Shimotsuke, Tochigi, Japan.Department of Neurology, Jichi Medical University, Shimotsuke, Tochigi, Japan.Department of Ophthalmology, Tokyo Medical University, Shinjyuku, Tokyo, Japan.Department of Pediatrics, Jichi Medical University, Shimotsuke, Tochigi, Japan.Department of Pediatrics, Jichi Medical University, Shimotsuke, Tochigi, Japan.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

24610298

Citation

Miyauchi, Akihiko, et al. "Persistent Presence of the Anti-myelin Oligodendrocyte Glycoprotein Autoantibody in a Pediatric Case of Acute Disseminated Encephalomyelitis Followed By Optic Neuritis." Neuropediatrics, vol. 45, no. 3, 2014, pp. 196-9.
Miyauchi A, Monden Y, Watanabe M, et al. Persistent presence of the anti-myelin oligodendrocyte glycoprotein autoantibody in a pediatric case of acute disseminated encephalomyelitis followed by optic neuritis. Neuropediatrics. 2014;45(3):196-9.
Miyauchi, A., Monden, Y., Watanabe, M., Sugie, H., Morita, M., Kezuka, T., Momoi, M., & Yamagata, T. (2014). Persistent presence of the anti-myelin oligodendrocyte glycoprotein autoantibody in a pediatric case of acute disseminated encephalomyelitis followed by optic neuritis. Neuropediatrics, 45(3), 196-9. https://doi.org/10.1055/s-0034-1371179
Miyauchi A, et al. Persistent Presence of the Anti-myelin Oligodendrocyte Glycoprotein Autoantibody in a Pediatric Case of Acute Disseminated Encephalomyelitis Followed By Optic Neuritis. Neuropediatrics. 2014;45(3):196-9. PubMed PMID: 24610298.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Persistent presence of the anti-myelin oligodendrocyte glycoprotein autoantibody in a pediatric case of acute disseminated encephalomyelitis followed by optic neuritis. AU - Miyauchi,Akihiko, AU - Monden,Yukifumi, AU - Watanabe,Meri, AU - Sugie,Hideo, AU - Morita,Mitsuya, AU - Kezuka,Takeshi, AU - Momoi,Mariko, AU - Yamagata,Takanori, Y1 - 2014/03/07/ PY - 2014/3/11/entrez PY - 2014/3/13/pubmed PY - 2015/1/22/medline SP - 196 EP - 9 JF - Neuropediatrics JO - Neuropediatrics VL - 45 IS - 3 N2 - We report the case of a 5-year-old Japanese girl who initially had acute disseminated encephalomyelitis (ADEM) and was positive for the myelin oligodendrocyte glycoprotein (MOG) antibodies and developed unilateral optic neuritis (ON) 71 days after ADEM onset. The patient's serum was positive for the anti-MOG antibodies from the onset of ADEM to the development of ON. This phenotype has been reported in only two previous articles, and the specific mechanism of action of the anti-MOG antibodies is not yet understood. Our case suggests that the anti-MOG antibody can be associated with the pathogenesis of ADEM followed by ON. Thus, patients with ADEM who test positive for the anti-MOG antibody may be at risk of developing subsequent ON. SN - 1439-1899 UR - https://www.unboundmedicine.com/medline/citation/24610298/Persistent_presence_of_the_anti_myelin_oligodendrocyte_glycoprotein_autoantibody_in_a_pediatric_case_of_acute_disseminated_encephalomyelitis_followed_by_optic_neuritis_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0034-1371179 DB - PRIME DP - Unbound Medicine ER -