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Does ondansetron have an effect on intramuscular ketamine-associated vomiting in children? A prospective, randomised, open, controlled study.
J Paediatr Child Health. 2014 Jul; 50(7):557-61.JP

Abstract

AIM

Ketamine is one of the most commonly used sedatives for facilitating painful procedures for paediatric patients in the emergency department (ED). However, the use of ketamine is associated with a common, though not serious, adverse event usually called ketamine-associated vomiting (KAV). The purpose of this study is to evaluate the anti-emetic effect of adjunctive ondansetron in paediatric patients receiving ketamine sedation in the ED.

METHODS

We conducted a prospective, randomised, open, controlled study in children from 1 to 18 years of age who had undergone intramuscular ketamine sedation in the ED. The patients were randomised into two groups: a ketamine-only group and a ketamine/ondansetron group. The patients in the first group received ketamine alone, while those in the second group received ketamine with oral ondansetron. The incidence of KAV was estimated in the ED and after discharge, and the time to resumption of a normal diet was measured after sedation.

RESULTS

A total of 237 patients were analysed. The incidence of KAV was 29.7% in the ketamine-only group and 25.2% in the ketamine/ondansetron group (P = 0.47). After administration of ketamine, the mean time to resumption of a normal diet was 8 h 54 min in the ketamine-only group and 8 h 39 min in the ketamine/ondansetron group (P = 0.67).

CONCLUSIONS

A relatively high rate of KAV (29.7%) was observed, and the time to resumption of a normal diet after ketamine sedation was rather long. It turned out that, however, the adjunctive administration of ondansetron did not effectively reduce the incidence of KAV.

Authors+Show Affiliations

Department of Emergency Medicine, Ajou University School of Medicine, Suwon, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

24612260

Citation

Lee, Ji Sook, et al. "Does Ondansetron Have an Effect On Intramuscular Ketamine-associated Vomiting in Children? a Prospective, Randomised, Open, Controlled Study." Journal of Paediatrics and Child Health, vol. 50, no. 7, 2014, pp. 557-61.
Lee JS, Jeon WC, Park EJ, et al. Does ondansetron have an effect on intramuscular ketamine-associated vomiting in children? A prospective, randomised, open, controlled study. J Paediatr Child Health. 2014;50(7):557-61.
Lee, J. S., Jeon, W. C., Park, E. J., Min, Y. G., Kim, G. W., Jung, Y. S., & Choi, S. C. (2014). Does ondansetron have an effect on intramuscular ketamine-associated vomiting in children? A prospective, randomised, open, controlled study. Journal of Paediatrics and Child Health, 50(7), 557-61. https://doi.org/10.1111/jpc.12515
Lee JS, et al. Does Ondansetron Have an Effect On Intramuscular Ketamine-associated Vomiting in Children? a Prospective, Randomised, Open, Controlled Study. J Paediatr Child Health. 2014;50(7):557-61. PubMed PMID: 24612260.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does ondansetron have an effect on intramuscular ketamine-associated vomiting in children? A prospective, randomised, open, controlled study. AU - Lee,Ji Sook, AU - Jeon,Woo Chan, AU - Park,Eun Jung, AU - Min,Young Gi, AU - Kim,Gi Woon, AU - Jung,Yoon Seok, AU - Choi,Sang Cheon, Y1 - 2014/02/25/ PY - 2013/11/30/accepted PY - 2014/3/12/entrez PY - 2014/3/13/pubmed PY - 2015/4/8/medline KW - ketamine KW - ondansetron KW - procedural sedation and analgesia SP - 557 EP - 61 JF - Journal of paediatrics and child health JO - J Paediatr Child Health VL - 50 IS - 7 N2 - AIM: Ketamine is one of the most commonly used sedatives for facilitating painful procedures for paediatric patients in the emergency department (ED). However, the use of ketamine is associated with a common, though not serious, adverse event usually called ketamine-associated vomiting (KAV). The purpose of this study is to evaluate the anti-emetic effect of adjunctive ondansetron in paediatric patients receiving ketamine sedation in the ED. METHODS: We conducted a prospective, randomised, open, controlled study in children from 1 to 18 years of age who had undergone intramuscular ketamine sedation in the ED. The patients were randomised into two groups: a ketamine-only group and a ketamine/ondansetron group. The patients in the first group received ketamine alone, while those in the second group received ketamine with oral ondansetron. The incidence of KAV was estimated in the ED and after discharge, and the time to resumption of a normal diet was measured after sedation. RESULTS: A total of 237 patients were analysed. The incidence of KAV was 29.7% in the ketamine-only group and 25.2% in the ketamine/ondansetron group (P = 0.47). After administration of ketamine, the mean time to resumption of a normal diet was 8 h 54 min in the ketamine-only group and 8 h 39 min in the ketamine/ondansetron group (P = 0.67). CONCLUSIONS: A relatively high rate of KAV (29.7%) was observed, and the time to resumption of a normal diet after ketamine sedation was rather long. It turned out that, however, the adjunctive administration of ondansetron did not effectively reduce the incidence of KAV. SN - 1440-1754 UR - https://www.unboundmedicine.com/medline/citation/24612260/Does_ondansetron_have_an_effect_on_intramuscular_ketamine_associated_vomiting_in_children_A_prospective_randomised_open_controlled_study_ L2 - https://doi.org/10.1111/jpc.12515 DB - PRIME DP - Unbound Medicine ER -