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Irregular tick-borne encephalitis vaccination schedules: the effect of a single catch-up vaccination with FSME-IMMUN. A prospective non-interventional study.
Vaccine. 2014 Apr 25; 32(20):2375-81.V

Abstract

BACKGROUND

Intervals longer than recommended are frequently encountered between doses of tick borne encephalitis virus (TBE) vaccines in both residents of and travelers to endemic regions. In clinical practice the management of individuals with lapsed TBE vaccination schedules varies widely and has in common that the underlying immunological evidence is scarce.

STUDY PURPOSE AND METHODS

The aim of this study was to generate data reliable enough to derive practical recommendations on how to continue vaccination with FSME-IMMUN in subjects with an irregular TBE vaccination history. Antibody response to a single catch-up dose of FSME-IMMUN was assessed in 1115 adults (age ≥16 years) and 125 children (age 6-15 years) with irregular TBE vaccination histories.

RESULTS

Subjects of all age groups developed a substantial increase in geometric mean antibody concentration after a single catch-up TBE vaccination which was consistently lower in subjects with only one previous TBE vaccination compared to subjects with two or more vaccinations. Overall, >94% of young adults and children, and >93% of elderly subjects with an irregular TBE vaccination history achieved antibody levels ≥25U/ml irrespective of the number of previous TBE vaccinations.

CONCLUSION

We conclude that TBE vaccination of subjects with irregular vaccination histories should be continued as if the previous vaccinations had been administered in a regular manner, with the stage of the vaccination schedule being determined by the number of previous vaccinations. Although lapsed vaccination schedules may leave subjects temporarily with inadequate protection against TBE infection, adequate protection can quickly be re-established in >93% of the subjects by a single catch-up dose of FSME-IMMUN, irrespective of age, number of previous vaccinations, and time interval since the last vaccination.

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Authors+Show Affiliations

Schosser R
Medical Affairs, Baxter Deutschland GmbH, Im Breitspiel 13, 69126 Heidelberg, Germany.
Reichert A
Medical Affairs Group DACH, Baxter Deutschland GmbH, Edisonstrasse 4, 85716 Unterschleiβheim, Germany. Electronic address: anja_reichert@baxter.com.
Mansmann U
Institute of Medical Informatics, Biometry, and Epidemiology, Faculty of Medicine, University of Munich, Marchioninistrasse 15, 81377 München, Germany.
Unger B
Global R&D, Baxter Bioscience, IZD Tower, Wagramer Strasse 17-19, 1220 Wien, Austria.
Heininger U
Division of Paediatric Infectious Diseases and Vaccinology, University Children's Hospital, Spitalstrasse 33, 4031 Basel, Switzerland.
Kaiser R
Neurological Clinic, Klinikum Pforzheim GmbH, Kanzlerstrasse 2-6, 75175 Pforzheim, Germany.

MeSH

AdolescentAdultAntibodies, ViralChildEncephalitis, Tick-BorneFemaleHumansImmunization ScheduleImmunization, SecondaryMaleMiddle AgedProspective StudiesViral VaccinesYoung Adult

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

24613521

Citation

Schosser, Rudolf, et al. "Irregular Tick-borne Encephalitis Vaccination Schedules: the Effect of a Single Catch-up Vaccination With FSME-IMMUN. a Prospective Non-interventional Study." Vaccine, vol. 32, no. 20, 2014, pp. 2375-81.
Schosser R, Reichert A, Mansmann U, et al. Irregular tick-borne encephalitis vaccination schedules: the effect of a single catch-up vaccination with FSME-IMMUN. A prospective non-interventional study. Vaccine. 2014;32(20):2375-81.
Schosser, R., Reichert, A., Mansmann, U., Unger, B., Heininger, U., & Kaiser, R. (2014). Irregular tick-borne encephalitis vaccination schedules: the effect of a single catch-up vaccination with FSME-IMMUN. A prospective non-interventional study. Vaccine, 32(20), 2375-81. https://doi.org/10.1016/j.vaccine.2014.01.072
Schosser R, et al. Irregular Tick-borne Encephalitis Vaccination Schedules: the Effect of a Single Catch-up Vaccination With FSME-IMMUN. a Prospective Non-interventional Study. Vaccine. 2014 Apr 25;32(20):2375-81. PubMed PMID: 24613521.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Irregular tick-borne encephalitis vaccination schedules: the effect of a single catch-up vaccination with FSME-IMMUN. A prospective non-interventional study. AU - Schosser,Rudolf, AU - Reichert,Anja, AU - Mansmann,Ulrich, AU - Unger,Bernd, AU - Heininger,Ulrich, AU - Kaiser,Reinhard, Y1 - 2014/03/06/ PY - 2013/11/14/received PY - 2014/01/16/revised PY - 2014/01/28/accepted PY - 2014/3/12/entrez PY - 2014/3/13/pubmed PY - 2014/10/4/medline KW - Delayed TBE vaccination KW - Irregular scheme KW - Reestablish protection SP - 2375 EP - 81 JF - Vaccine JO - Vaccine VL - 32 IS - 20 N2 - BACKGROUND: Intervals longer than recommended are frequently encountered between doses of tick borne encephalitis virus (TBE) vaccines in both residents of and travelers to endemic regions. In clinical practice the management of individuals with lapsed TBE vaccination schedules varies widely and has in common that the underlying immunological evidence is scarce. STUDY PURPOSE AND METHODS: The aim of this study was to generate data reliable enough to derive practical recommendations on how to continue vaccination with FSME-IMMUN in subjects with an irregular TBE vaccination history. Antibody response to a single catch-up dose of FSME-IMMUN was assessed in 1115 adults (age ≥16 years) and 125 children (age 6-15 years) with irregular TBE vaccination histories. RESULTS: Subjects of all age groups developed a substantial increase in geometric mean antibody concentration after a single catch-up TBE vaccination which was consistently lower in subjects with only one previous TBE vaccination compared to subjects with two or more vaccinations. Overall, >94% of young adults and children, and >93% of elderly subjects with an irregular TBE vaccination history achieved antibody levels ≥25U/ml irrespective of the number of previous TBE vaccinations. CONCLUSION: We conclude that TBE vaccination of subjects with irregular vaccination histories should be continued as if the previous vaccinations had been administered in a regular manner, with the stage of the vaccination schedule being determined by the number of previous vaccinations. Although lapsed vaccination schedules may leave subjects temporarily with inadequate protection against TBE infection, adequate protection can quickly be re-established in >93% of the subjects by a single catch-up dose of FSME-IMMUN, irrespective of age, number of previous vaccinations, and time interval since the last vaccination. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/24613521/Irregular_tick_borne_encephalitis_vaccination_schedules:_the_effect_of_a_single_catch_up_vaccination_with_FSME_IMMUN__A_prospective_non_interventional_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(14)00135-2 DB - PRIME DP - Unbound Medicine ER -