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Fatty acids, inflammation, and asthma.
J Allergy Clin Immunol 2014; 133(5):1255-64JA

Abstract

Fatty acids and consequently diet play an essential role in the formation of inflammatory mediators involved in the pathogenesis of asthma. Because intake variations of omega-6 (n-6) and omega-3 (n-3) fatty acids ultimately determine cell membrane incorporation, changes in diet have the potential to modify downstream production of inflammatory mediators derived from these compounds. It has long been hypothesized that decreasing the n-6/n-3 ratio could reduce the production of more proinflammatory mediators while increasing the formation of downstream metabolites that can serve to limit or resolve inflammation. In turn, these changes would result in improved asthma outcomes or would lower the risk for asthma incidence. This review will focus on the role of fatty acid inflammatory and resolving mediators and will summarize the clinical and epidemiologic data on how diet and obesity alter fatty acid profiles that can contribute to asthma.

Authors+Show Affiliations

Asthma Institute, UPMC, Department of Medicine, Pittsburgh, Pa.Asthma Institute, UPMC, Department of Medicine, Pittsburgh, Pa.Asthma Institute, UPMC, Department of Medicine, Pittsburgh, Pa. Electronic address: feh9@pitt.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24613565

Citation

Wendell, Stacy Gelhaus, et al. "Fatty Acids, Inflammation, and Asthma." The Journal of Allergy and Clinical Immunology, vol. 133, no. 5, 2014, pp. 1255-64.
Wendell SG, Baffi C, Holguin F. Fatty acids, inflammation, and asthma. J Allergy Clin Immunol. 2014;133(5):1255-64.
Wendell, S. G., Baffi, C., & Holguin, F. (2014). Fatty acids, inflammation, and asthma. The Journal of Allergy and Clinical Immunology, 133(5), pp. 1255-64. doi:10.1016/j.jaci.2013.12.1087.
Wendell SG, Baffi C, Holguin F. Fatty Acids, Inflammation, and Asthma. J Allergy Clin Immunol. 2014;133(5):1255-64. PubMed PMID: 24613565.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fatty acids, inflammation, and asthma. AU - Wendell,Stacy Gelhaus, AU - Baffi,Cindy, AU - Holguin,Fernando, Y1 - 2014/03/07/ PY - 2013/09/11/received PY - 2013/12/23/revised PY - 2013/12/31/accepted PY - 2014/3/12/entrez PY - 2014/3/13/pubmed PY - 2014/8/20/medline KW - Asthma KW - diet KW - fatty acids KW - inflammation KW - n-3 KW - n-6 KW - obesity KW - resolution SP - 1255 EP - 64 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 133 IS - 5 N2 - Fatty acids and consequently diet play an essential role in the formation of inflammatory mediators involved in the pathogenesis of asthma. Because intake variations of omega-6 (n-6) and omega-3 (n-3) fatty acids ultimately determine cell membrane incorporation, changes in diet have the potential to modify downstream production of inflammatory mediators derived from these compounds. It has long been hypothesized that decreasing the n-6/n-3 ratio could reduce the production of more proinflammatory mediators while increasing the formation of downstream metabolites that can serve to limit or resolve inflammation. In turn, these changes would result in improved asthma outcomes or would lower the risk for asthma incidence. This review will focus on the role of fatty acid inflammatory and resolving mediators and will summarize the clinical and epidemiologic data on how diet and obesity alter fatty acid profiles that can contribute to asthma. SN - 1097-6825 UR - https://www.unboundmedicine.com/medline/citation/24613565/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(14)00086-4 DB - PRIME DP - Unbound Medicine ER -