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Visual acuity after cataract surgery in patients with age-related macular degeneration: age-related eye disease study 2 report number 5.
Ophthalmology. 2014 Jun; 121(6):1229-36.O

Abstract

OBJECTIVE

To evaluate visual acuity outcomes after cataract surgery in persons with varying degrees of severity of age-related macular degeneration (AMD).

DESIGN

Cohort study.

PARTICIPANTS

A total of 1232 eyes of 793 participants who underwent cataract surgery during the Age-Related Eye Disease Study 2, a prospective, multicenter, randomized controlled trial of nutritional supplements for treatment of AMD.

METHODS

Preoperative and postoperative characteristics of participants who underwent cataract extraction during the 5-year trial were analyzed. Both clinical data and standardized red-reflex lens and fundus photographs were obtained at baseline and annually. Photographs were graded by a centralized reading center for cortical and posterior subcapsular lens opacities and for AMD severity. Cataract surgery was documented at annual study visits or by history during the 6-month telephone calls. Analyses were conducted using multivariate repeated-measures regression.

MAIN OUTCOME MEASURES

Change in best-corrected visual acuity (BCVA) after cataract surgery compared with preoperative BCVA.

RESULTS

Adjusting for age at time of surgery, gender, interval between preoperative and postoperative visits, and type and severity of cataract, the mean changes in visual acuity were as follows: eyes with mild AMD (n = 30) gained 11.2 letters (95% confidence interval [CI], 6.9-15.5), eyes with moderate AMD (n = 346) gained 11.1 letters (95% CI, 9.1-13.2), eyes with severe AMD (n = 462) gained 8.7 letters (95% CI, 6.7-10.7), eyes with noncentral geographic atrophy (n = 70) gained 8.9 letters (95% CI, 5.8-12.1), and eyes with advanced AMD (central geographic atrophy, neovascular disease, or both; n = 324) gained 6.8 letters (95% CI, 4.9-8.8). The visual acuity gain across all AMD severity groups was statistically significant from preoperative values (P < 0.0001).

CONCLUSIONS

Mean visual acuities improved significantly after cataract surgery across varying degrees of AMD severity.

Authors+Show Affiliations

No affiliation info availableClinical Trials Branch, Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland.Clinical Trials Branch, Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland.Clinical Trials Branch, Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland.EMMES Corporation, Rockville, Maryland.Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland.Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.Clinical Trials Branch, Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland. Electronic address: echew@nei.nih.gov.

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24613825

Citation

Age-Related Eye Disease Study 2 Research Group, et al. "Visual Acuity After Cataract Surgery in Patients With Age-related Macular Degeneration: Age-related Eye Disease Study 2 Report Number 5." Ophthalmology, vol. 121, no. 6, 2014, pp. 1229-36.
Age-Related Eye Disease Study 2 Research Group, Huynh N, Nicholson BP, et al. Visual acuity after cataract surgery in patients with age-related macular degeneration: age-related eye disease study 2 report number 5. Ophthalmology. 2014;121(6):1229-36.
Huynh, N., Nicholson, B. P., Agrón, E., Clemons, T. E., Bressler, S. B., Rosenfeld, P. J., & Chew, E. Y. (2014). Visual acuity after cataract surgery in patients with age-related macular degeneration: age-related eye disease study 2 report number 5. Ophthalmology, 121(6), 1229-36. https://doi.org/10.1016/j.ophtha.2013.12.035
Age-Related Eye Disease Study 2 Research Group, et al. Visual Acuity After Cataract Surgery in Patients With Age-related Macular Degeneration: Age-related Eye Disease Study 2 Report Number 5. Ophthalmology. 2014;121(6):1229-36. PubMed PMID: 24613825.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Visual acuity after cataract surgery in patients with age-related macular degeneration: age-related eye disease study 2 report number 5. AU - ,, AU - Huynh,Nancy, AU - Nicholson,Benjamin P, AU - Agrón,Elvira, AU - Clemons,Traci E, AU - Bressler,Susan B, AU - Rosenfeld,Philip J, AU - Chew,Emily Y, Y1 - 2014/03/07/ PY - 2013/10/21/received PY - 2013/12/27/revised PY - 2013/12/30/accepted PY - 2014/3/12/entrez PY - 2014/3/13/pubmed PY - 2014/8/16/medline SP - 1229 EP - 36 JF - Ophthalmology JO - Ophthalmology VL - 121 IS - 6 N2 - OBJECTIVE: To evaluate visual acuity outcomes after cataract surgery in persons with varying degrees of severity of age-related macular degeneration (AMD). DESIGN: Cohort study. PARTICIPANTS: A total of 1232 eyes of 793 participants who underwent cataract surgery during the Age-Related Eye Disease Study 2, a prospective, multicenter, randomized controlled trial of nutritional supplements for treatment of AMD. METHODS: Preoperative and postoperative characteristics of participants who underwent cataract extraction during the 5-year trial were analyzed. Both clinical data and standardized red-reflex lens and fundus photographs were obtained at baseline and annually. Photographs were graded by a centralized reading center for cortical and posterior subcapsular lens opacities and for AMD severity. Cataract surgery was documented at annual study visits or by history during the 6-month telephone calls. Analyses were conducted using multivariate repeated-measures regression. MAIN OUTCOME MEASURES: Change in best-corrected visual acuity (BCVA) after cataract surgery compared with preoperative BCVA. RESULTS: Adjusting for age at time of surgery, gender, interval between preoperative and postoperative visits, and type and severity of cataract, the mean changes in visual acuity were as follows: eyes with mild AMD (n = 30) gained 11.2 letters (95% confidence interval [CI], 6.9-15.5), eyes with moderate AMD (n = 346) gained 11.1 letters (95% CI, 9.1-13.2), eyes with severe AMD (n = 462) gained 8.7 letters (95% CI, 6.7-10.7), eyes with noncentral geographic atrophy (n = 70) gained 8.9 letters (95% CI, 5.8-12.1), and eyes with advanced AMD (central geographic atrophy, neovascular disease, or both; n = 324) gained 6.8 letters (95% CI, 4.9-8.8). The visual acuity gain across all AMD severity groups was statistically significant from preoperative values (P < 0.0001). CONCLUSIONS: Mean visual acuities improved significantly after cataract surgery across varying degrees of AMD severity. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/24613825/Visual_acuity_after_cataract_surgery_in_patients_with_age_related_macular_degeneration:_age_related_eye_disease_study_2_report_number_5_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(13)01256-6 DB - PRIME DP - Unbound Medicine ER -