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Influence of pre-existing hemagglutination inhibition titers against historical influenza strains on antibody response to inactivated trivalent influenza vaccine in adults 50-80 years of age.
Hum Vaccin Immunother 2014; 10(5):1195-203HV

Abstract

BACKGROUND

Concerns about influenza vaccine effectiveness in older adults and the role of influenza strains encountered earlier in life led to this study.

METHODS

Antibody responses against antigens in the 2011-2012 influenza vaccine at 21 days post vaccination were analyzed in 264 individuals aged 50-80 years. At Days 0 and 21, sera were tested for hemagglutination-inhibition titers against these vaccine strains and at Day 0 against a panel of 15 historical seasonal strains.:

RESULTS

The proportions of participants with seroprotective titers ≥1:40 to the vaccine strains at Days 0 and 21, respectively, were 37% and 66% for A(H1N1) and 28% and 63% for A(H3N2). An increasing number of responses ≥1:40 against historical strains was associated with seroprotective responses after vaccination among participants with a titer<1:40 at Day 0 for A(H1N1) and A(H3N2) vaccine strains (P<0.01). In multivariable regression analyses among those with Day 0 titer<1:40, after controlling for age, sex, race, site and diabetes, Day 21 titers ≥ 1:40 for the vaccine A strains were significantly more likely as the number of seroprotective responses against historical strains increased (A(H1N1) odds ratio [OR] = 1.41, 95% confidence interval [CI] = 1.09-1.82 and A(H3N2) OR = 1.32, 95% CI = 1.07-1.62). The likelihood of seroconversion was significantly higher with an increasing number of responses to historical strains for A(H3N2) only (OR = 1.24, 95% CI = 1.01-1.52). Seroconversion was significantly less likely as Day 0 vaccine strain titers increased.

CONCLUSIONS

Seroprotective titers after influenza vaccination increased as the number of responses to historical strains increased.

Authors+Show Affiliations

Center for Vaccine Research; University of Pittsburgh; Pittsburgh, PA USA; Vaccine & Gene Therapy Institute of Florida; Port Saint Lucie, FL USA.Department of Family Medicine; School of Medicine; University of Pittsburgh; Pittsburgh, PA USA.Department of Family Medicine; School of Medicine; University of Pittsburgh; Pittsburgh, PA USA.Department of Family Medicine; School of Medicine; University of Pittsburgh; Pittsburgh, PA USA.Centers for Disease Control and Prevention; Influenza Division/NCIRD; Atlanta, GA USA.Centers for Disease Control and Prevention; Influenza Division/NCIRD; Atlanta, GA USA.Centers for Disease Control and Prevention; Influenza Division/NCIRD; Atlanta, GA USA.Marshfield Clinic Research Foundation; Marshfield, WI USA.Department of Pathobiological Sciences; University of Wisconsin School of Veterinary Medicine; Madison, WI USA; Wisconsin National Primate Research Center; Madison, WI USA.UPMC St. Margaret's Family Medicine Residency, Pittsburgh, PA USA.Center for Vaccine Research; University of Pittsburgh; Pittsburgh, PA USA; Vaccine & Gene Therapy Institute of Florida; Port Saint Lucie, FL USA.Department of Family Medicine; School of Medicine; University of Pittsburgh; Pittsburgh, PA USA.

Pub Type(s)

Journal Article
Multicenter Study
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

24614078

Citation

Ross, Ted M., et al. "Influence of Pre-existing Hemagglutination Inhibition Titers Against Historical Influenza Strains On Antibody Response to Inactivated Trivalent Influenza Vaccine in Adults 50-80 Years of Age." Human Vaccines & Immunotherapeutics, vol. 10, no. 5, 2014, pp. 1195-203.
Ross TM, Lin CJ, Nowalk MP, et al. Influence of pre-existing hemagglutination inhibition titers against historical influenza strains on antibody response to inactivated trivalent influenza vaccine in adults 50-80 years of age. Hum Vaccin Immunother. 2014;10(5):1195-203.
Ross, T. M., Lin, C. J., Nowalk, M. P., Huang, H. H., Spencer, S. M., Shay, D. K., ... Zimmerman, R. K. (2014). Influence of pre-existing hemagglutination inhibition titers against historical influenza strains on antibody response to inactivated trivalent influenza vaccine in adults 50-80 years of age. Human Vaccines & Immunotherapeutics, 10(5), pp. 1195-203. doi:10.4161/hv.28313.
Ross TM, et al. Influence of Pre-existing Hemagglutination Inhibition Titers Against Historical Influenza Strains On Antibody Response to Inactivated Trivalent Influenza Vaccine in Adults 50-80 Years of Age. Hum Vaccin Immunother. 2014;10(5):1195-203. PubMed PMID: 24614078.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of pre-existing hemagglutination inhibition titers against historical influenza strains on antibody response to inactivated trivalent influenza vaccine in adults 50-80 years of age. AU - Ross,Ted M, AU - Lin,Chyongchiou Jeng, AU - Nowalk,Mary Patricia, AU - Huang,Hsin-Hui, AU - Spencer,Sarah M, AU - Shay,David K, AU - Sambhara,Suryaprakash, AU - Sundaram,Maria E, AU - Friedrich,Thomas, AU - Sauereisen,Sandy, AU - Bloom,Chalise E, AU - Zimmerman,Richard K, Y1 - 2014/03/10/ PY - 2014/3/12/entrez PY - 2014/3/13/pubmed PY - 2015/6/24/medline KW - Human influenza KW - antibodies KW - immune response KW - immunogenicity SP - 1195 EP - 203 JF - Human vaccines & immunotherapeutics JO - Hum Vaccin Immunother VL - 10 IS - 5 N2 - BACKGROUND: Concerns about influenza vaccine effectiveness in older adults and the role of influenza strains encountered earlier in life led to this study. METHODS: Antibody responses against antigens in the 2011-2012 influenza vaccine at 21 days post vaccination were analyzed in 264 individuals aged 50-80 years. At Days 0 and 21, sera were tested for hemagglutination-inhibition titers against these vaccine strains and at Day 0 against a panel of 15 historical seasonal strains.: RESULTS: The proportions of participants with seroprotective titers ≥1:40 to the vaccine strains at Days 0 and 21, respectively, were 37% and 66% for A(H1N1) and 28% and 63% for A(H3N2). An increasing number of responses ≥1:40 against historical strains was associated with seroprotective responses after vaccination among participants with a titer<1:40 at Day 0 for A(H1N1) and A(H3N2) vaccine strains (P<0.01). In multivariable regression analyses among those with Day 0 titer<1:40, after controlling for age, sex, race, site and diabetes, Day 21 titers ≥ 1:40 for the vaccine A strains were significantly more likely as the number of seroprotective responses against historical strains increased (A(H1N1) odds ratio [OR] = 1.41, 95% confidence interval [CI] = 1.09-1.82 and A(H3N2) OR = 1.32, 95% CI = 1.07-1.62). The likelihood of seroconversion was significantly higher with an increasing number of responses to historical strains for A(H3N2) only (OR = 1.24, 95% CI = 1.01-1.52). Seroconversion was significantly less likely as Day 0 vaccine strain titers increased. CONCLUSIONS: Seroprotective titers after influenza vaccination increased as the number of responses to historical strains increased. SN - 2164-554X UR - https://www.unboundmedicine.com/medline/citation/24614078/Influence_of_pre_existing_hemagglutination_inhibition_titers_against_historical_influenza_strains_on_antibody_response_to_inactivated_trivalent_influenza_vaccine_in_adults_50_80_years_of_age_ L2 - http://www.tandfonline.com/doi/full/10.4161/hv.28313 DB - PRIME DP - Unbound Medicine ER -