Tags

Type your tag names separated by a space and hit enter

Decrease of urinary nerve growth factor but not brain-derived neurotrophic factor in patients with interstitial cystitis/bladder pain syndrome treated with hyaluronic acid.
PLoS One. 2014; 9(3):e91609.Plos

Abstract

AIMS

To investigate urinary nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) levels in interstitial cystitis/bladder pain syndrome (IC/BPS) patients after hyaluronic acid (HA) therapy.

METHODS

Thirty-three patients with IC/BPS were prospectively studied; a group of 45 age-matched healthy subjects served as controls. All IC/BPS patients received nine intravesical HA instillations during the 6-month treatment regimen. Urine samples were collected for measuring urinary NGF and BDNF levels at baseline and 2 weeks after the last HA treatment. The clinical parameters including visual analog scale (VAS) of pain, daily frequency nocturia episodes, functional bladder capacity (FBC) and global response assessment (GRA) were recorded. Urinary NGF and BDNF levels were compared between IC/BPS patients and controls at baseline and after HA treatment.

RESULTS

Urinary NGF, NGF/Cr, BDNF, and BDNF/Cr levels were significantly higher in IC/BPS patients compared to controls. Both NGF and NGF/Cr levels significantly decreased after HA treatment. Urinary NGF and NGF/Cr levels significantly decreased in the responders with a VAS pain reduction by 2 (both p < 0.05) and the GRA improved by 2 (both p < 0.05), but not in non-responders. Urinary BDNF and BDNF/Cr did not decrease in responders or non-responders after HA therapy.

CONCLUSIONS

Urinary NGF, but not BDNF, levels decreased significantly after HA therapy; both of these factors remained higher than in controls even after HA treatment. HA had a beneficial effect on IC/BPS, but it was limited. The reduction of urinary NGF levels was significant in responders, with a reduction of pain and improved GRA.

Authors+Show Affiliations

Department of Urology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan.Department of Urology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan; Institute of Pharmacology and Toxicology, Tzu Chi University, Hualien, Taiwan.Department of Urology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan.

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

24614892

Citation

Jiang, Yuan-Hong, et al. "Decrease of Urinary Nerve Growth Factor but Not Brain-derived Neurotrophic Factor in Patients With Interstitial Cystitis/bladder Pain Syndrome Treated With Hyaluronic Acid." PloS One, vol. 9, no. 3, 2014, pp. e91609.
Jiang YH, Liu HT, Kuo HC. Decrease of urinary nerve growth factor but not brain-derived neurotrophic factor in patients with interstitial cystitis/bladder pain syndrome treated with hyaluronic acid. PLoS One. 2014;9(3):e91609.
Jiang, Y. H., Liu, H. T., & Kuo, H. C. (2014). Decrease of urinary nerve growth factor but not brain-derived neurotrophic factor in patients with interstitial cystitis/bladder pain syndrome treated with hyaluronic acid. PloS One, 9(3), e91609. https://doi.org/10.1371/journal.pone.0091609
Jiang YH, Liu HT, Kuo HC. Decrease of Urinary Nerve Growth Factor but Not Brain-derived Neurotrophic Factor in Patients With Interstitial Cystitis/bladder Pain Syndrome Treated With Hyaluronic Acid. PLoS One. 2014;9(3):e91609. PubMed PMID: 24614892.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decrease of urinary nerve growth factor but not brain-derived neurotrophic factor in patients with interstitial cystitis/bladder pain syndrome treated with hyaluronic acid. AU - Jiang,Yuan-Hong, AU - Liu,Hsin-Tzu, AU - Kuo,Hann-Chorng, Y1 - 2014/03/10/ PY - 2013/11/07/received PY - 2014/02/12/accepted PY - 2014/3/12/entrez PY - 2014/3/13/pubmed PY - 2016/4/1/medline SP - e91609 EP - e91609 JF - PloS one JO - PLoS One VL - 9 IS - 3 N2 - AIMS: To investigate urinary nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) levels in interstitial cystitis/bladder pain syndrome (IC/BPS) patients after hyaluronic acid (HA) therapy. METHODS: Thirty-three patients with IC/BPS were prospectively studied; a group of 45 age-matched healthy subjects served as controls. All IC/BPS patients received nine intravesical HA instillations during the 6-month treatment regimen. Urine samples were collected for measuring urinary NGF and BDNF levels at baseline and 2 weeks after the last HA treatment. The clinical parameters including visual analog scale (VAS) of pain, daily frequency nocturia episodes, functional bladder capacity (FBC) and global response assessment (GRA) were recorded. Urinary NGF and BDNF levels were compared between IC/BPS patients and controls at baseline and after HA treatment. RESULTS: Urinary NGF, NGF/Cr, BDNF, and BDNF/Cr levels were significantly higher in IC/BPS patients compared to controls. Both NGF and NGF/Cr levels significantly decreased after HA treatment. Urinary NGF and NGF/Cr levels significantly decreased in the responders with a VAS pain reduction by 2 (both p < 0.05) and the GRA improved by 2 (both p < 0.05), but not in non-responders. Urinary BDNF and BDNF/Cr did not decrease in responders or non-responders after HA therapy. CONCLUSIONS: Urinary NGF, but not BDNF, levels decreased significantly after HA therapy; both of these factors remained higher than in controls even after HA treatment. HA had a beneficial effect on IC/BPS, but it was limited. The reduction of urinary NGF levels was significant in responders, with a reduction of pain and improved GRA. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/24614892/Decrease_of_urinary_nerve_growth_factor_but_not_brain_derived_neurotrophic_factor_in_patients_with_interstitial_cystitis/bladder_pain_syndrome_treated_with_hyaluronic_acid_ L2 - https://dx.plos.org/10.1371/journal.pone.0091609 DB - PRIME DP - Unbound Medicine ER -