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Differences in nutritional status between very mild Alzheimer's disease patients and healthy controls.
J Alzheimers Dis 2014; 41(1):261-71JA

Abstract

BACKGROUND

Studies on the systemic availability of nutrients and nutritional status in Alzheimer's disease (AD) are widely available, but the majority included patients in a moderate stage of AD.

OBJECTIVE

This study compares the nutritional status between mild AD outpatients and healthy controls.

METHODS

A subgroup of Dutch drug-naïve patients with mild AD (Mini-Mental State Examination (MMSE) ≥20) from the Souvenir II randomized controlled study (NTR1975) and a group of Dutch healthy controls were included. Nutritional status was assessed by measuring levels of several nutrients, conducting the Mini Nutritional Assessment (MNA®) questionnaire and through anthropometric measures.

RESULTS

In total, data of 93 healthy cognitively intact controls (MMSE 29.0 [23.0-30.0]) and 79 very mild AD patients (MMSE = 25.0 [20.0-30.0]) were included. Plasma selenium (p < 0.001) and uridine (p = 0.046) levels were significantly lower in AD patients, with a similar trend for plasma vitamin D (p = 0.094) levels. In addition, the fatty acid profile in erythrocyte membranes was different between groups for several fatty acids. Mean MNA screening score was significantly lower in AD patients (p = 0.008), but not indicative of malnutrition risk. No significant differences were observed for other micronutrient or anthropometric parameters.

CONCLUSION

In non-malnourished patients with very mild AD, lower levels of some micronutrients, a different fatty acid profile in erythrocyte membranes and a slightly but significantly lower MNA screening score were observed. This suggests that subtle differences in nutrient status are present already in a very early stage of AD and in the absence of protein/energy malnutrition.

Authors+Show Affiliations

Radboud Alzheimer Center, Department of Geriatric Medicine, Radboud University Hospital, Nijmegen, The Netherlands.Alzheimer Center Limburg, Maastricht University Medical Center, Maastricht, The Netherlands.Nutricia Research, Utrecht, The Netherlands.Neurology Department, Catharina Ziekenhuis, Eindhoven, The Netherlands.Geriatrics Department, Jeroen Bosch Ziekenhuis, 's-Hertogenbosch, The Netherlands.Nutricia Research, Utrecht, The Netherlands.Department of Geriatric Medicine, Orbis Medisch Centrum, Sittard, The Netherlands.Department of Geriatric Medicine, Medical Center Leeuwarden, Leeuwarden, The Netherlands.Nutricia Research, Utrecht, The Netherlands.Neurology Department, Tergooiziekenhuizen Blaricum, Blaricum, The Netherlands.Gerontopole, INSERM U 1027, Toulouse, France.Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands.

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24614903

Citation

Olde Rikkert, Marcel G M., et al. "Differences in Nutritional Status Between Very Mild Alzheimer's Disease Patients and Healthy Controls." Journal of Alzheimer's Disease : JAD, vol. 41, no. 1, 2014, pp. 261-71.
Olde Rikkert MG, Verhey FR, Sijben JW, et al. Differences in nutritional status between very mild Alzheimer's disease patients and healthy controls. J Alzheimers Dis. 2014;41(1):261-71.
Olde Rikkert, M. G., Verhey, F. R., Sijben, J. W., Bouwman, F. H., Dautzenberg, P. L., Lansink, M., ... Scheltens, P. (2014). Differences in nutritional status between very mild Alzheimer's disease patients and healthy controls. Journal of Alzheimer's Disease : JAD, 41(1), pp. 261-71. doi:10.3233/JAD-131892.
Olde Rikkert MG, et al. Differences in Nutritional Status Between Very Mild Alzheimer's Disease Patients and Healthy Controls. J Alzheimers Dis. 2014;41(1):261-71. PubMed PMID: 24614903.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differences in nutritional status between very mild Alzheimer's disease patients and healthy controls. AU - Olde Rikkert,Marcel G M, AU - Verhey,Frans R, AU - Sijben,John W C, AU - Bouwman,Femke H, AU - Dautzenberg,Paul L J, AU - Lansink,Mirian, AU - Sipers,Walther M W, AU - van Asselt,Dieneke Z B, AU - van Hees,Anneke M J, AU - Stevens,Martijn, AU - Vellas,Bruno, AU - Scheltens,Philip, PY - 2014/3/12/entrez PY - 2014/3/13/pubmed PY - 2015/1/30/medline KW - Alzheimer's disease KW - fatty acids KW - healthy volunteers KW - micronutrients KW - nutritional status KW - protein-energy malnutrition SP - 261 EP - 71 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 41 IS - 1 N2 - BACKGROUND: Studies on the systemic availability of nutrients and nutritional status in Alzheimer's disease (AD) are widely available, but the majority included patients in a moderate stage of AD. OBJECTIVE: This study compares the nutritional status between mild AD outpatients and healthy controls. METHODS: A subgroup of Dutch drug-naïve patients with mild AD (Mini-Mental State Examination (MMSE) ≥20) from the Souvenir II randomized controlled study (NTR1975) and a group of Dutch healthy controls were included. Nutritional status was assessed by measuring levels of several nutrients, conducting the Mini Nutritional Assessment (MNA®) questionnaire and through anthropometric measures. RESULTS: In total, data of 93 healthy cognitively intact controls (MMSE 29.0 [23.0-30.0]) and 79 very mild AD patients (MMSE = 25.0 [20.0-30.0]) were included. Plasma selenium (p < 0.001) and uridine (p = 0.046) levels were significantly lower in AD patients, with a similar trend for plasma vitamin D (p = 0.094) levels. In addition, the fatty acid profile in erythrocyte membranes was different between groups for several fatty acids. Mean MNA screening score was significantly lower in AD patients (p = 0.008), but not indicative of malnutrition risk. No significant differences were observed for other micronutrient or anthropometric parameters. CONCLUSION: In non-malnourished patients with very mild AD, lower levels of some micronutrients, a different fatty acid profile in erythrocyte membranes and a slightly but significantly lower MNA screening score were observed. This suggests that subtle differences in nutrient status are present already in a very early stage of AD and in the absence of protein/energy malnutrition. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/24614903/Differences_in_nutritional_status_between_very_mild_Alzheimer's_disease_patients_and_healthy_controls_ L2 - https://content.iospress.com/openurl?genre=article&amp;id=doi:10.3233/JAD-131892 DB - PRIME DP - Unbound Medicine ER -