Tags

Type your tag names separated by a space and hit enter

Impact of methylenetetrahydrofolate reductase polymorphisms and folate intake on the risk of gastric cancer and their association with Helicobacter pylori infection and tumor site.
Genet Mol Res 2014; 13(4):9718-26GM

Abstract

Folic acid and methylenetetrahydrofolate reductase (MTHFR) may both affect the development of human cancer. We conducted a population-based case-control study in a Chinese population to investigate the potential role of folate intake and MTHFR gene polymorphisms in gastric cancer, and their interaction with infection by Helicobacter pylori and tumor location. A total of 767 patients with newly diagnosed gastric cancer and 775 controls were selected for this study. Genotyping of MTHFR C677T and A1298C was conducted by TaqMan assays using the ABI Prism 7911HT Sequence Detection System, and information on folate intake was collected by questionnaire. Compared with the CC genotype of MTHFR C677T, the TT genotype was significantly associated with a decreased risk of gastric cancer when the analysis was adjusted for other potential risk factors. We found a marginal significantly decreased risk of gastric cancer for individuals carrying the T allele [adjusted odds ratio (OR) = 0.83; 95% confidence interval (CI) = 0.65-1.01]. We detected an inverse relationship between folate intake and risk of gastric cancer, and the adjusted ORs (95%CI) for moderate and high folate intake were 0.97 (0.74-1.25) and 0.64 (0.49-0.87), respectively. Moreover, H. pylori infection, folate intake, and location of the tumor showed a significant interaction with the MTHFR C677T polymorphism. Our study suggests a protective role of MTHFR 677TT and high folate intake against gastric cancer, and the effect of the MTHFR C677T genotype may differ by H. pylori infection, folate consumption, and tumor site.

Authors+Show Affiliations

Department of Cadre Ward, The General Hospital of Chengdu Military Area, Chengdu, China.Department of Cadre Ward, The General Hospital of Chengdu Military Area, Chengdu, China.Department of Cadre Ward, The General Hospital of Chengdu Military Area, Chengdu, China.Department of Thoracic Surgery, The General Hospital of Chengdu Military Area, Chengdu, China.Department of Cadre Ward, The General Hospital of Chengdu Military Area, Chengdu, China.Department of Nuclear Medicine, The General Hospital of Chengdu Military Area, Chengdu, China.Department of Cadre Ward, The General Hospital of Chengdu Military Area, Chengdu, China sun_suxia@yahoo.com.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24615072

Citation

Chen, J, et al. "Impact of Methylenetetrahydrofolate Reductase Polymorphisms and Folate Intake On the Risk of Gastric Cancer and Their Association With Helicobacter Pylori Infection and Tumor Site." Genetics and Molecular Research : GMR, vol. 13, no. 4, 2014, pp. 9718-26.
Chen J, Yuan L, Duan YQ, et al. Impact of methylenetetrahydrofolate reductase polymorphisms and folate intake on the risk of gastric cancer and their association with Helicobacter pylori infection and tumor site. Genet Mol Res. 2014;13(4):9718-26.
Chen, J., Yuan, L., Duan, Y. Q., Jiang, J. Q., Zhang, R., Huang, Z. J., & Xiao, X. R. (2014). Impact of methylenetetrahydrofolate reductase polymorphisms and folate intake on the risk of gastric cancer and their association with Helicobacter pylori infection and tumor site. Genetics and Molecular Research : GMR, 13(4), pp. 9718-26. doi:10.4238/2014.January.24.2.
Chen J, et al. Impact of Methylenetetrahydrofolate Reductase Polymorphisms and Folate Intake On the Risk of Gastric Cancer and Their Association With Helicobacter Pylori Infection and Tumor Site. Genet Mol Res. 2014 Jan 24;13(4):9718-26. PubMed PMID: 24615072.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of methylenetetrahydrofolate reductase polymorphisms and folate intake on the risk of gastric cancer and their association with Helicobacter pylori infection and tumor site. AU - Chen,J, AU - Yuan,L, AU - Duan,Y Q, AU - Jiang,J Q, AU - Zhang,R, AU - Huang,Z J, AU - Xiao,X R, Y1 - 2014/01/24/ PY - 2014/3/12/entrez PY - 2014/3/13/pubmed PY - 2015/8/5/medline SP - 9718 EP - 26 JF - Genetics and molecular research : GMR JO - Genet. Mol. Res. VL - 13 IS - 4 N2 - Folic acid and methylenetetrahydrofolate reductase (MTHFR) may both affect the development of human cancer. We conducted a population-based case-control study in a Chinese population to investigate the potential role of folate intake and MTHFR gene polymorphisms in gastric cancer, and their interaction with infection by Helicobacter pylori and tumor location. A total of 767 patients with newly diagnosed gastric cancer and 775 controls were selected for this study. Genotyping of MTHFR C677T and A1298C was conducted by TaqMan assays using the ABI Prism 7911HT Sequence Detection System, and information on folate intake was collected by questionnaire. Compared with the CC genotype of MTHFR C677T, the TT genotype was significantly associated with a decreased risk of gastric cancer when the analysis was adjusted for other potential risk factors. We found a marginal significantly decreased risk of gastric cancer for individuals carrying the T allele [adjusted odds ratio (OR) = 0.83; 95% confidence interval (CI) = 0.65-1.01]. We detected an inverse relationship between folate intake and risk of gastric cancer, and the adjusted ORs (95%CI) for moderate and high folate intake were 0.97 (0.74-1.25) and 0.64 (0.49-0.87), respectively. Moreover, H. pylori infection, folate intake, and location of the tumor showed a significant interaction with the MTHFR C677T polymorphism. Our study suggests a protective role of MTHFR 677TT and high folate intake against gastric cancer, and the effect of the MTHFR C677T genotype may differ by H. pylori infection, folate consumption, and tumor site. SN - 1676-5680 UR - https://www.unboundmedicine.com/medline/citation/24615072/Impact_of_methylenetetrahydrofolate_reductase_polymorphisms_and_folate_intake_on_the_risk_of_gastric_cancer_and_their_association_with_Helicobacter_pylori_infection_and_tumor_site_ L2 - http://www.geneticsmr.com/articles/2807 DB - PRIME DP - Unbound Medicine ER -