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Vitamin D with asthma and COPD: not a false hope? A systematic review and meta-analysis.

Abstract

Vitamin D deficiency and insufficiency are increasingly being recognized in the general population over the last few decades. However, a number of other disorders have now been linked to vitamin D deficiency and insufficiency, including asthma and COPD. The aim of this study was to evaluate the evidence on the effect of vitamin D on asthma and COPD. We searched electronic databases including SCI, EMBASE, Ovid, and PubMed. Reviewers working independently and in duplicate extracted study characteristics, quality, and the outcomes. The weighted mean differences across trials and random-effect meta-analysis were used to pool the relative risks (RR). This is the first meta-analysis about the risk of vitamin D deficiency for asthma and COPD. Ten studies were available for this meta-analysis and systematic review. The prevalence of vitamin D deficiency was significantly greater among cases than control subjects [RR=1.59, 95%CI=1.07-2.36, 488/812 (60%) vs 278/875 (32%)] for asthma. However, vitamin D insufficiency was not significantly associated with asthma [RR=1.09, 95%CI=0.91-1.30, 702/996 (70%) vs 665/1016 (65%)]. Moreover, studies failed to demonstrate that COPD patients had an increased risk for vitamin D deficiency or insufficiency compared to controls (RR=0.89, 95%CI=0.63-1.25). Vitamin D deficiency was associated with a significant decrease in lung function in asthmatic children. Vitamin D deficiency was highly prevalent in asthma patients, and vitamin D status was associated with lung function. COPD cannot be considered as completely free of vitamin D deficiency.

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  • Authors+Show Affiliations

    ,

    Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

    ,

    Departments of Obstetrics/Gynecology, West China Second Hospital, Chengdu, Sichuan, China.

    Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China zll280831@163.com.

    Source

    Genetics and molecular research : GMR 13:3 2014 Feb 13 pg 7607-16

    MeSH

    Asthma
    Disease Progression
    Humans
    Odds Ratio
    Pulmonary Disease, Chronic Obstructive
    Vitamin D
    Vitamin D Deficiency

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    24615096

    Citation

    Zhang, L L., et al. "Vitamin D With Asthma and COPD: Not a False Hope? a Systematic Review and Meta-analysis." Genetics and Molecular Research : GMR, vol. 13, no. 3, 2014, pp. 7607-16.
    Zhang LL, Gong J, Liu CT. Vitamin D with asthma and COPD: not a false hope? A systematic review and meta-analysis. Genet Mol Res. 2014;13(3):7607-16.
    Zhang, L. L., Gong, J., & Liu, C. T. (2014). Vitamin D with asthma and COPD: not a false hope? A systematic review and meta-analysis. Genetics and Molecular Research : GMR, 13(3), pp. 7607-16. doi:10.4238/2014.February.13.10.
    Zhang LL, Gong J, Liu CT. Vitamin D With Asthma and COPD: Not a False Hope? a Systematic Review and Meta-analysis. Genet Mol Res. 2014 Feb 13;13(3):7607-16. PubMed PMID: 24615096.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vitamin D with asthma and COPD: not a false hope? A systematic review and meta-analysis. AU - Zhang,L L, AU - Gong,J, AU - Liu,C T, Y1 - 2014/02/13/ PY - 2014/3/12/entrez PY - 2014/3/13/pubmed PY - 2016/4/26/medline SP - 7607 EP - 16 JF - Genetics and molecular research : GMR JO - Genet. Mol. Res. VL - 13 IS - 3 N2 - Vitamin D deficiency and insufficiency are increasingly being recognized in the general population over the last few decades. However, a number of other disorders have now been linked to vitamin D deficiency and insufficiency, including asthma and COPD. The aim of this study was to evaluate the evidence on the effect of vitamin D on asthma and COPD. We searched electronic databases including SCI, EMBASE, Ovid, and PubMed. Reviewers working independently and in duplicate extracted study characteristics, quality, and the outcomes. The weighted mean differences across trials and random-effect meta-analysis were used to pool the relative risks (RR). This is the first meta-analysis about the risk of vitamin D deficiency for asthma and COPD. Ten studies were available for this meta-analysis and systematic review. The prevalence of vitamin D deficiency was significantly greater among cases than control subjects [RR=1.59, 95%CI=1.07-2.36, 488/812 (60%) vs 278/875 (32%)] for asthma. However, vitamin D insufficiency was not significantly associated with asthma [RR=1.09, 95%CI=0.91-1.30, 702/996 (70%) vs 665/1016 (65%)]. Moreover, studies failed to demonstrate that COPD patients had an increased risk for vitamin D deficiency or insufficiency compared to controls (RR=0.89, 95%CI=0.63-1.25). Vitamin D deficiency was associated with a significant decrease in lung function in asthmatic children. Vitamin D deficiency was highly prevalent in asthma patients, and vitamin D status was associated with lung function. COPD cannot be considered as completely free of vitamin D deficiency. SN - 1676-5680 UR - https://www.unboundmedicine.com/medline/citation/24615096/full_citation L2 - http://www.geneticsmr.com/articles/2861 DB - PRIME DP - Unbound Medicine ER -