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Mouse models of diabetic neuropathy.
ILAR J 2014; 54(3):259-72IJ

Abstract

Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes and is associated with significant morbidity and mortality. DPN is characterized by progressive, distal-to-proximal degeneration of peripheral nerves that leads to pain, weakness, and eventual loss of sensation. The mechanisms underlying DPN pathogenesis are uncertain, and other than tight glycemic control in type 1 patients, there is no effective treatment. Mouse models of type 1 (T1DM) and type 2 diabetes (T2DM) are critical to improving our understanding of DPN pathophysiology and developing novel treatment strategies. In this review, we discuss the most widely used T1DM and T2DM mouse models for DPN research, with emphasis on the main neurologic phenotype of each model. We also discuss important considerations for selecting appropriate models for T1DM and T2DM DPN studies and describe the promise of novel emerging diabetic mouse models for DPN research. The development, characterization, and comprehensive neurologic phenotyping of clinically relevant mouse models for T1DM and T2DM will provide valuable resources for future studies examining DPN pathogenesis and novel therapeutic strategies.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24615439

Citation

O'Brien, Phillipe D., et al. "Mouse Models of Diabetic Neuropathy." ILAR Journal, vol. 54, no. 3, 2014, pp. 259-72.
O'Brien PD, Sakowski SA, Feldman EL. Mouse models of diabetic neuropathy. ILAR J. 2014;54(3):259-72.
O'Brien, P. D., Sakowski, S. A., & Feldman, E. L. (2014). Mouse models of diabetic neuropathy. ILAR Journal, 54(3), pp. 259-72. doi:10.1093/ilar/ilt052.
O'Brien PD, Sakowski SA, Feldman EL. Mouse Models of Diabetic Neuropathy. ILAR J. 2014;54(3):259-72. PubMed PMID: 24615439.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mouse models of diabetic neuropathy. AU - O'Brien,Phillipe D, AU - Sakowski,Stacey A, AU - Feldman,Eva L, PY - 2014/3/12/entrez PY - 2014/3/13/pubmed PY - 2015/2/3/medline KW - diabetic peripheral neuropathy KW - diet-induced obesity KW - leptin KW - mouse models KW - nerve conduction velocity KW - nerve fiber density KW - type 1 diabetes KW - type 2 diabetes SP - 259 EP - 72 JF - ILAR journal JO - ILAR J VL - 54 IS - 3 N2 - Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes and is associated with significant morbidity and mortality. DPN is characterized by progressive, distal-to-proximal degeneration of peripheral nerves that leads to pain, weakness, and eventual loss of sensation. The mechanisms underlying DPN pathogenesis are uncertain, and other than tight glycemic control in type 1 patients, there is no effective treatment. Mouse models of type 1 (T1DM) and type 2 diabetes (T2DM) are critical to improving our understanding of DPN pathophysiology and developing novel treatment strategies. In this review, we discuss the most widely used T1DM and T2DM mouse models for DPN research, with emphasis on the main neurologic phenotype of each model. We also discuss important considerations for selecting appropriate models for T1DM and T2DM DPN studies and describe the promise of novel emerging diabetic mouse models for DPN research. The development, characterization, and comprehensive neurologic phenotyping of clinically relevant mouse models for T1DM and T2DM will provide valuable resources for future studies examining DPN pathogenesis and novel therapeutic strategies. SN - 1930-6180 UR - https://www.unboundmedicine.com/medline/citation/24615439/Mouse_models_of_diabetic_neuropathy_ L2 - https://academic.oup.com/ilarjournal/article-lookup/doi/10.1093/ilar/ilt052 DB - PRIME DP - Unbound Medicine ER -