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The armadillo as a model for peripheral neuropathy in leprosy.
ILAR J. 2014; 54(3):304-14.IJ

Abstract

Leprosy (also known as Hansen's Disease) is a chronic infectious disease caused by Mycobacterium leprae that primarily targets the peripheral nervous system; skin, muscle, and other tissues are also affected. Other than humans, nine-banded armadillos (Dasypus novemcinctus) are the only natural hosts of M. leprae, and they are the only laboratory animals that develop extensive neurological involvement with this bacterium. Infection in the armadillo closely recapitulates many of the structural, physiological, and functional aspects of leprosy seen in humans. Armadillos can be useful models of leprosy for basic scientific investigations into the pathogenesis of leprosy neuropathy and its associated myopathies, as well as for translational research studies in piloting new diagnostic methods or therapeutic interventions. Practical and ethical constraints often limit investigation into human neuropathies, but armadillos are an abundant source of leprotic neurologic fibers. Studies with these animals may provide new insights into the mechanisms involved in leprosy that also might benefit the understanding of other demyelinating neuropathies. Although there is only a limited supply of armadillo-specific reagents, the armadillo whole genomic sequence has been completed, and gene expression studies can be employed. Clinical procedures, such as electrophysiological nerve conduction testing, provide a functional assessment of armadillo nerves. A variety of standard histopathological and immunopathological procedures including Epidermal Nerve Fiber Density (ENFD) analysis, Schwann Cell Density, and analysis for other conserved cellular markers can be used effectively with armadillos and will be briefly reviewed in this text.

Authors

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Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

24615444

Citation

Truman, Richard W., et al. "The Armadillo as a Model for Peripheral Neuropathy in Leprosy." ILAR Journal, vol. 54, no. 3, 2014, pp. 304-14.
Truman RW, Ebenezer GJ, Pena MT, et al. The armadillo as a model for peripheral neuropathy in leprosy. ILAR J. 2014;54(3):304-14.
Truman, R. W., Ebenezer, G. J., Pena, M. T., Sharma, R., Balamayooran, G., Gillingwater, T. H., Scollard, D. M., McArthur, J. C., & Rambukkana, A. (2014). The armadillo as a model for peripheral neuropathy in leprosy. ILAR Journal, 54(3), 304-14. https://doi.org/10.1093/ilar/ilt050
Truman RW, et al. The Armadillo as a Model for Peripheral Neuropathy in Leprosy. ILAR J. 2014;54(3):304-14. PubMed PMID: 24615444.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The armadillo as a model for peripheral neuropathy in leprosy. AU - Truman,Richard W, AU - Ebenezer,Gigi J, AU - Pena,Maria T, AU - Sharma,Rahul, AU - Balamayooran,Gayathriy, AU - Gillingwater,Thomas H, AU - Scollard,David M, AU - McArthur,Justin C, AU - Rambukkana,Anura, PY - 2014/3/12/entrez PY - 2014/3/13/pubmed PY - 2015/2/3/medline KW - ENFD KW - Schwann cell KW - armadillo KW - gene-expression KW - leprosy KW - myopathy KW - neuropathy KW - translational SP - 304 EP - 14 JF - ILAR journal JO - ILAR J VL - 54 IS - 3 N2 - Leprosy (also known as Hansen's Disease) is a chronic infectious disease caused by Mycobacterium leprae that primarily targets the peripheral nervous system; skin, muscle, and other tissues are also affected. Other than humans, nine-banded armadillos (Dasypus novemcinctus) are the only natural hosts of M. leprae, and they are the only laboratory animals that develop extensive neurological involvement with this bacterium. Infection in the armadillo closely recapitulates many of the structural, physiological, and functional aspects of leprosy seen in humans. Armadillos can be useful models of leprosy for basic scientific investigations into the pathogenesis of leprosy neuropathy and its associated myopathies, as well as for translational research studies in piloting new diagnostic methods or therapeutic interventions. Practical and ethical constraints often limit investigation into human neuropathies, but armadillos are an abundant source of leprotic neurologic fibers. Studies with these animals may provide new insights into the mechanisms involved in leprosy that also might benefit the understanding of other demyelinating neuropathies. Although there is only a limited supply of armadillo-specific reagents, the armadillo whole genomic sequence has been completed, and gene expression studies can be employed. Clinical procedures, such as electrophysiological nerve conduction testing, provide a functional assessment of armadillo nerves. A variety of standard histopathological and immunopathological procedures including Epidermal Nerve Fiber Density (ENFD) analysis, Schwann Cell Density, and analysis for other conserved cellular markers can be used effectively with armadillos and will be briefly reviewed in this text. SN - 1930-6180 UR - https://www.unboundmedicine.com/medline/citation/24615444/The_armadillo_as_a_model_for_peripheral_neuropathy_in_leprosy_ L2 - https://academic.oup.com/ilarjournal/article-lookup/doi/10.1093/ilar/ilt050 DB - PRIME DP - Unbound Medicine ER -