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Associations between urine excretion of isoflavonoids and cognition in postmenopausal women in the Women's Isoflavone Soy Health clinical trial.

Abstract

OBJECTIVES

To determine effect of change in urine excretion of isoflavonoids on cognitive change.

DESIGN

Post hoc analysis of isoflavonoid exposure (mean 2.7 years) during the randomized, placebo-controlled, double-blind Women's Isoflavone Soy Health trial.

SETTING

General community.

PARTICIPANTS

Healthy postmenopausal women (N = 350).

INTERVENTION

Twenty-five grams of isoflavone-rich soy protein (91 mg of aglycone weight isoflavones: 52 mg genistein, 36 mg daidzein, 3 mg glycitein) or milk protein-matched placebo provided daily.

MEASUREMENTS

Overnight urine excretion, fasting plasma levels of isoflavonoids, and cognitive function measured at baseline and endpoint.

RESULTS

Three hundred women (age: mean 61, range 45-92) completed both cognitive assessments and did not use hormone replacement therapy during the trial. Mean on-trial change from baseline in urine excretion of isoflavonoids was not significantly associated with change in a composite score of global cognition (P = .39). Secondary analyses indicated that change in urine excretion of isoflavonoids was inversely associated with change in a factor score representing general intelligence (P = .02) but not with factor scores representing verbal or visual episodic memory. Mean differences in this general intelligence factor score between women in the lowest and highest quartiles of isoflavonoid change were equivalent to an approximate 4.4-year age-associated decline. Analyses based on plasma isoflavonoid levels yielded similar but attenuated results.

CONCLUSION

In healthy postmenopausal women, long-term changes in isoflavonoids are not associated with global cognition, supporting clinical trial results, although greater isoflavonoid exposure from dietary supplements is associated with decrements in general intelligence but not memory; this finding requires confirmation in future studies.

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  • Authors+Show Affiliations

    ,

    Atherosclerosis Research Unit, University of Southern California, Los Angeles, California; Department of Preventive Medicine, University of Southern California, Los Angeles, California.

    , , , , ,

    Source

    MeSH

    Aged
    Aged, 80 and over
    Atherosclerosis
    Cognition
    Cognition Disorders
    Dietary Supplements
    Dose-Response Relationship, Drug
    Double-Blind Method
    Female
    Humans
    Isoflavones
    Memory
    Middle Aged
    Plant Proteins, Dietary
    Postmenopause
    Prognosis
    Reference Values
    Soybean Proteins
    Time Factors
    Urinalysis
    Women's Health

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    24617349

    Citation

    St John, Jan A., et al. "Associations Between Urine Excretion of Isoflavonoids and Cognition in Postmenopausal Women in the Women's Isoflavone Soy Health Clinical Trial." Journal of the American Geriatrics Society, vol. 62, no. 4, 2014, pp. 629-35.
    St John JA, Henderson VW, Hodis HN, et al. Associations between urine excretion of isoflavonoids and cognition in postmenopausal women in the Women's Isoflavone Soy Health clinical trial. J Am Geriatr Soc. 2014;62(4):629-35.
    St John, J. A., Henderson, V. W., Hodis, H. N., Kono, N., McCleary, C. A., Franke, A. A., & Mack, W. J. (2014). Associations between urine excretion of isoflavonoids and cognition in postmenopausal women in the Women's Isoflavone Soy Health clinical trial. Journal of the American Geriatrics Society, 62(4), pp. 629-35. doi:10.1111/jgs.12752.
    St John JA, et al. Associations Between Urine Excretion of Isoflavonoids and Cognition in Postmenopausal Women in the Women's Isoflavone Soy Health Clinical Trial. J Am Geriatr Soc. 2014;62(4):629-35. PubMed PMID: 24617349.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Associations between urine excretion of isoflavonoids and cognition in postmenopausal women in the Women's Isoflavone Soy Health clinical trial. AU - St John,Jan A, AU - Henderson,Victor W, AU - Hodis,Howard N, AU - Kono,Naoko, AU - McCleary,Carol A, AU - Franke,Adrian A, AU - Mack,Wendy J, Y1 - 2014/03/11/ PY - 2014/3/13/entrez PY - 2014/3/13/pubmed PY - 2014/6/4/medline KW - cognition KW - isoflavones KW - menopause KW - soy KW - women's health SP - 629 EP - 35 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 62 IS - 4 N2 - OBJECTIVES: To determine effect of change in urine excretion of isoflavonoids on cognitive change. DESIGN: Post hoc analysis of isoflavonoid exposure (mean 2.7 years) during the randomized, placebo-controlled, double-blind Women's Isoflavone Soy Health trial. SETTING: General community. PARTICIPANTS: Healthy postmenopausal women (N = 350). INTERVENTION: Twenty-five grams of isoflavone-rich soy protein (91 mg of aglycone weight isoflavones: 52 mg genistein, 36 mg daidzein, 3 mg glycitein) or milk protein-matched placebo provided daily. MEASUREMENTS: Overnight urine excretion, fasting plasma levels of isoflavonoids, and cognitive function measured at baseline and endpoint. RESULTS: Three hundred women (age: mean 61, range 45-92) completed both cognitive assessments and did not use hormone replacement therapy during the trial. Mean on-trial change from baseline in urine excretion of isoflavonoids was not significantly associated with change in a composite score of global cognition (P = .39). Secondary analyses indicated that change in urine excretion of isoflavonoids was inversely associated with change in a factor score representing general intelligence (P = .02) but not with factor scores representing verbal or visual episodic memory. Mean differences in this general intelligence factor score between women in the lowest and highest quartiles of isoflavonoid change were equivalent to an approximate 4.4-year age-associated decline. Analyses based on plasma isoflavonoid levels yielded similar but attenuated results. CONCLUSION: In healthy postmenopausal women, long-term changes in isoflavonoids are not associated with global cognition, supporting clinical trial results, although greater isoflavonoid exposure from dietary supplements is associated with decrements in general intelligence but not memory; this finding requires confirmation in future studies. SN - 1532-5415 UR - https://www.unboundmedicine.com/medline/citation/24617349/Associations_between_urine_excretion_of_isoflavonoids_and_cognition_in_postmenopausal_women_in_the_Women's_Isoflavone_Soy_Health_clinical_trial_ L2 - https://doi.org/10.1111/jgs.12752 DB - PRIME DP - Unbound Medicine ER -