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Absence of a late-phase response or increase in histamine responsiveness after bronchial provocation with adenosine 5'-monophosphate in atopic and non-atopic asthma.
Clin Sci (Lond) 1988; 75(4):429-36CS

Abstract

1. Adenosine 5'-monophosphate (AMP) causes bronchoconstriction in atopic and non-atopic asthma by a mechanism believed to involve histamine release from airway mast cells. To determine whether preformed mast cell mediators, principally histamine, can initiate a late-phase bronchoconstriction we have investigated the effect on the airways over a 24 h period of a single bronchial challenge with AMP. 2. Six atopic asthmatic subjects (all late responders to inhaled allergen) and six non-atopic asthmatic subjects were studied on two occasions for a 24 h period after inhalation of the provocation concentration of AMP required to produce a 20% fall in forced expiratory volume in 1 s (FEV1) from baseline (PC20) and 0.9% (w/v) sodium chloride placebo, respectively. The atopic asthmatic subjects were studied on a further occasion after challenge with the PC20 allergen. 3. Inhalation of the PC20 AMP resulted in an immediate fall in FEV1 to a mean maximum 25.5% below baseline without resulting in any late decrease in airway calibre. No significant increase in non-specific bronchial responsiveness as determined by measuring the PC20 histamine before, and at 3, 9 and 24 h after, AMP challenge, occurred. Inhalation of the PC20 allergen caused a reproducible late-phase bronchoconstriction and increase in non-specific bronchial responsiveness in all the atopic asthmatic subjects studied. 4. These results suggest that preformed mast cell mediators, principally histamine, play no role in the initiation of the late-phase reaction in allergen-provoked asthma, although they may contribute to the inflammatory changes involved.

Authors+Show Affiliations

Immunopharmacology Group, Southampton General Hospital, U.K.No affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2461826

Citation

Phillips, G D., and S T. Holgate. "Absence of a Late-phase Response or Increase in Histamine Responsiveness After Bronchial Provocation With Adenosine 5'-monophosphate in Atopic and Non-atopic Asthma." Clinical Science (London, England : 1979), vol. 75, no. 4, 1988, pp. 429-36.
Phillips GD, Holgate ST. Absence of a late-phase response or increase in histamine responsiveness after bronchial provocation with adenosine 5'-monophosphate in atopic and non-atopic asthma. Clin Sci. 1988;75(4):429-36.
Phillips, G. D., & Holgate, S. T. (1988). Absence of a late-phase response or increase in histamine responsiveness after bronchial provocation with adenosine 5'-monophosphate in atopic and non-atopic asthma. Clinical Science (London, England : 1979), 75(4), pp. 429-36.
Phillips GD, Holgate ST. Absence of a Late-phase Response or Increase in Histamine Responsiveness After Bronchial Provocation With Adenosine 5'-monophosphate in Atopic and Non-atopic Asthma. Clin Sci. 1988;75(4):429-36. PubMed PMID: 2461826.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Absence of a late-phase response or increase in histamine responsiveness after bronchial provocation with adenosine 5'-monophosphate in atopic and non-atopic asthma. AU - Phillips,G D, AU - Holgate,S T, PY - 1988/10/1/pubmed PY - 1988/10/1/medline PY - 1988/10/1/entrez SP - 429 EP - 36 JF - Clinical science (London, England : 1979) JO - Clin. Sci. VL - 75 IS - 4 N2 - 1. Adenosine 5'-monophosphate (AMP) causes bronchoconstriction in atopic and non-atopic asthma by a mechanism believed to involve histamine release from airway mast cells. To determine whether preformed mast cell mediators, principally histamine, can initiate a late-phase bronchoconstriction we have investigated the effect on the airways over a 24 h period of a single bronchial challenge with AMP. 2. Six atopic asthmatic subjects (all late responders to inhaled allergen) and six non-atopic asthmatic subjects were studied on two occasions for a 24 h period after inhalation of the provocation concentration of AMP required to produce a 20% fall in forced expiratory volume in 1 s (FEV1) from baseline (PC20) and 0.9% (w/v) sodium chloride placebo, respectively. The atopic asthmatic subjects were studied on a further occasion after challenge with the PC20 allergen. 3. Inhalation of the PC20 AMP resulted in an immediate fall in FEV1 to a mean maximum 25.5% below baseline without resulting in any late decrease in airway calibre. No significant increase in non-specific bronchial responsiveness as determined by measuring the PC20 histamine before, and at 3, 9 and 24 h after, AMP challenge, occurred. Inhalation of the PC20 allergen caused a reproducible late-phase bronchoconstriction and increase in non-specific bronchial responsiveness in all the atopic asthmatic subjects studied. 4. These results suggest that preformed mast cell mediators, principally histamine, play no role in the initiation of the late-phase reaction in allergen-provoked asthma, although they may contribute to the inflammatory changes involved. SN - 0143-5221 UR - https://www.unboundmedicine.com/medline/citation/2461826/Absence_of_a_late_phase_response_or_increase_in_histamine_responsiveness_after_bronchial_provocation_with_adenosine_5'_monophosphate_in_atopic_and_non_atopic_asthma_ L2 - http://clinsci.org/cgi/pmidlookup?view=long&pmid=2461826 DB - PRIME DP - Unbound Medicine ER -